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Items: 18


Combined Treatment with MEK and mTOR Inhibitors is Effective in In Vitro and In Vivo Models of Hepatocellular Carcinoma.

Liu X, Hu J, Song X, Utpatel K, Zhang Y, Wang P, Lu X, Zhang J, Xu M, Su T, Che L, Wang J, Evert M, Calvisi DF, Chen X.

Cancers (Basel). 2019 Jul 3;11(7). pii: E930. doi: 10.3390/cancers11070930.


Loss of Fbxw7 synergizes with activated AKT signaling to promote c-Myc dependent cholangiocarcinogenesis.

Wang J, Wang H, Peters M, Ding N, Ribback S, Utpatel K, Cigliano A, Dombrowski F, Xu M, Chen X, Song X, Che L, Evert M, Cossu A, Gordan J, Zeng Y, Chen X, Calvisi DF.

J Hepatol. 2019 Jun 10. pii: S0168-8278(19)30342-3. doi: 10.1016/j.jhep.2019.05.027. [Epub ahead of print]


Functional role of SGK3 in PI3K/Pten driven liver tumor development.

Cao H, Xu Z, Wang J, Cigliano A, Pilo MG, Ribback S, Zhang S, Qiao Y, Che L, Pascale RM, Calvisi DF, Chen X.

BMC Cancer. 2019 Apr 11;19(1):343. doi: 10.1186/s12885-019-5551-2.


Cholesterol biosynthesis supports the growth of hepatocarcinoma lesions depleted of fatty acid synthase in mice and humans.

Che L, Chi W, Qiao Y, Zhang J, Song X, Liu Y, Li L, Jia J, Pilo MG, Wang J, Cigliano A, Ma Z, Kuang W, Tang Z, Zhang Z, Shui G, Ribback S, Dombrowski F, Evert M, Pascale RM, Cossu C, Pes GM, Osborne TF, Calvisi DF, Chen X, Chen L.

Gut. 2019 Apr 6. pii: gutjnl-2018-317581. doi: 10.1136/gutjnl-2018-317581. [Epub ahead of print]


Axis inhibition protein 1 (Axin1) Deletion-Induced Hepatocarcinogenesis Requires Intact β-Catenin but Not Notch Cascade in Mice.

Qiao Y, Wang J, Karagoz E, Liang B, Song X, Shang R, Evert K, Xu M, Che L, Evert M, Calvisi DF, Tao J, Wang B, Monga SP, Chen X.

Hepatology. 2019 Feb 8. doi: 10.1002/hep.30556. [Epub ahead of print]


All-trans retinoic acid can antagonize osteoblastogenesis induced by different BMPs irrespective of their dimerization types and dose-efficiencies.

Liu Y, Ma X, Guo J, Lin Z, Zhou M, Bi W, Liu J, Wang J, Lu H, Wu G.

Drug Des Devel Ther. 2018 Oct 10;12:3419-3430. doi: 10.2147/DDDT.S178190. eCollection 2018.


Combined CDK4/6 and Pan-mTOR Inhibition Is Synergistic Against Intrahepatic Cholangiocarcinoma.

Song X, Liu X, Wang H, Wang J, Qiao Y, Cigliano A, Utpatel K, Ribback S, Pilo MG, Serra M, Gordan JD, Che L, Zhang S, Cossu A, Porcu A, Pascale RM, Dombrowski F, Hu H, Calvisi DF, Evert M, Chen X.

Clin Cancer Res. 2019 Jan 1;25(1):403-413. doi: 10.1158/1078-0432.CCR-18-0284. Epub 2018 Jul 3.


Inhibition of growth and metastasis of triple-negative breast cancer targeted by Traditional Chinese Medicine Tubeimu in orthotopic mice models.

Wang J, Yang X, Han H, Wang L, Bao W, Wang S, Hoffman RM, Yang M, Qi H, An C, Hu K.

Chin J Cancer Res. 2018 Feb;30(1):112-121. doi: 10.21147/j.issn.1000-9604.2018.01.12.


Notch2 controls hepatocyte-derived cholangiocarcinoma formation in mice.

Wang J, Dong M, Xu Z, Song X, Zhang S, Qiao Y, Che L, Gordan J, Hu K, Liu Y, Calvisi DF, Chen X.

Oncogene. 2018 Jun;37(24):3229-3242. doi: 10.1038/s41388-018-0188-1. Epub 2018 Mar 16.


Highly Ordered Hierarchical Pt and PtNi Nanowire Arrays for Enhanced Electrocatalytic Activity toward Methanol Oxidation.

Wang C, Zhang Y, Zhang Y, Xu P, Feng C, Chen T, Guo T, Yang F, Wang Q, Wang J, Shi M, Fan L, Chen S.

ACS Appl Mater Interfaces. 2018 Mar 21;10(11):9444-9450. doi: 10.1021/acsami.7b19727. Epub 2018 Mar 8.


Hippo Cascade Controls Lineage Commitment of Liver Tumors in Mice and Humans.

Zhang S, Wang J, Wang H, Fan L, Fan B, Zeng B, Tao J, Li X, Che L, Cigliano A, Ribback S, Dombrowski F, Chen B, Cong W, Wei L, Calvisi DF, Chen X.

Am J Pathol. 2018 Apr;188(4):995-1006. doi: 10.1016/j.ajpath.2017.12.017. Epub 2018 Jan 31.


Multivariate linear regression analysis to identify general factors for quantitative predictions of implant stability quotient values.

Huang H, Xu Z, Shao X, Wismeijer D, Sun P, Wang J, Wu G.

PLoS One. 2017 Oct 30;12(10):e0187010. doi: 10.1371/journal.pone.0187010. eCollection 2017.


Glucose Catabolism in Liver Tumors Induced by c-MYC Can Be Sustained by Various PKM1/PKM2 Ratios and Pyruvate Kinase Activities.

Méndez-Lucas A, Li X, Hu J, Che L, Song X, Jia J, Wang J, Xie C, Driscoll PC, Tschaharganeh DF, Calvisi DF, Yuneva M, Chen X.

Cancer Res. 2017 Aug 15;77(16):4355-4364. doi: 10.1158/0008-5472.CAN-17-0498. Epub 2017 Jun 19.


Role of the Notch signaling in cholangiocarcinoma.

Cigliano A, Wang J, Chen X, Calvisi DF.

Expert Opin Ther Targets. 2017 May;21(5):471-483. doi: 10.1080/14728222.2017.1310842. Epub 2017 Mar 30. Review.


Biomaterials with Antibacterial and Osteoinductive Properties to Repair Infected Bone Defects.

Lu H, Liu Y, Guo J, Wu H, Wang J, Wu G.

Int J Mol Sci. 2016 Mar 3;17(3):334. doi: 10.3390/ijms17030334. Review.


BMP2/7 heterodimer is a stronger inducer of bone regeneration in peri-implant bone defects model than BMP2 or BMP7 homodimer.

Sun P, Wang J, Zheng Y, Fan Y, Gu Z.

Dent Mater J. 2012;31(2):239-48. Epub 2012 Mar 23.


Low-dose rhBMP2/7 heterodimer to reconstruct peri-implant bone defects: a micro-CT evaluation.

Wang J, Zheng Y, Zhao J, Liu T, Gao L, Gu Z, Wu G.

J Clin Periodontol. 2012 Jan;39(1):98-105. doi: 10.1111/j.1600-051X.2011.01807.x. Epub 2011 Nov 10.


Calcium-sensing receptors induce apoptosis in rat cardiomyocytes via the endo(sarco)plasmic reticulum pathway during hypoxia/reoxygenation.

Lu F, Tian Z, Zhang W, Zhao Y, Bai S, Ren H, Chen H, Yu X, Wang J, Wang L, Li H, Pan Z, Tian Y, Yang B, Wang R, Xu C.

Basic Clin Pharmacol Toxicol. 2010 May;106(5):396-405. doi: 10.1111/j.1742-7843.2009.00502.x. Epub 2009 Dec 22.

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