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Nat Commun. 2017 Mar 27;8:14822. doi: 10.1038/ncomms14822.

The soybean GmSNAP18 gene underlies two types of resistance to soybean cyst nematode.

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Department of Plant, Soil and Agricultural Systems, Southern Illinois University, 1205 Lincoln Drive RM176, Carbondale, Illinois 62901, USA.
Division of Plant Sciences and Bond Life Sciences Center, University of Missouri, Columbia, Missouri 65211, USA.
Generation Biotech, Lawrenceville, New Jersey 08648, USA.
GenXPro-GmbH, Altenhöferallee 3, 60438 Frankfurt am Main, Germany.
Department of Agronomy, Iowa State University, Ames, Iowa 50011, USA.


Two types of resistant soybean (Glycine max (L.) Merr.) sources are widely used against soybean cyst nematode (SCN, Heterodera glycines Ichinohe). These include Peking-type soybean, whose resistance requires both the rhg1-a and Rhg4 alleles, and PI 88788-type soybean, whose resistance requires only the rhg1-b allele. Multiple copy number of PI 88788-type GmSNAP18, GmAAT, and GmWI12 in one genomic segment simultaneously contribute to rhg1-b resistance. Using an integrated set of genetic and genomic approaches, we demonstrate that the rhg1-a Peking-type GmSNAP18 is sufficient for resistance to SCN in combination with Rhg4. The two SNAPs (soluble NSF attachment proteins) differ by only five amino acids. Our findings suggest that Peking-type GmSNAP18 is performing a different role in SCN resistance than PI 88788-type GmSNAP18. As such, this is an example of a pathogen resistance gene that has evolved to underlie two types of resistance, yet ensure the same function within a single plant species.

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