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Items: 1 to 20 of 41


Red blood cell metabolism in Rhesus macaques and humans: comparative biology of blood storage.

Stefanoni D, Shin HKH, Baek JH, Champagne DP, Nemkov T, Thomas T, Francis RO, Zimring JC, Yoshida T, Reisz JA, Spitalnik SL, Buehler PW, D'Alessandro A.

Haematologica. 2019 Nov 7. pii: haematol.2019.229930. doi: 10.3324/haematol.2019.229930. [Epub ahead of print]


Novel manufacturing method for producing apohemoglobin and its biophysical properties.

Pires IS, Belcher DA, Hickey R, Miller C, Badu-Tawiah AK, Baek JH, Buehler PW, Palmer AF.

Biotechnol Bioeng. 2020 Jan;117(1):125-145. doi: 10.1002/bit.27193. Epub 2019 Nov 15.


Can molecular markers of oxygen homeostasis and the measurement of tissue oxygen be leveraged to optimize red blood cell transfusions?

Baek JH, Buehler PW.

Curr Opin Hematol. 2019 Nov;26(6):453-460. doi: 10.1097/MOH.0000000000000533.


Haptoglobin administration into the subarachnoid space prevents hemoglobin-induced cerebral vasospasm.

Hugelshofer M, Buzzi RM, Schaer CA, Richter H, Akeret K, Anagnostakou V, Mahmoudi L, Vaccani R, Vallelian F, Deuel JW, Kronen PW, Kulcsar Z, Regli L, Baek JH, Pires IS, Palmer AF, Dennler M, Humar R, Buehler PW, Kircher PR, Keller E, Schaer DJ.

J Clin Invest. 2019 Dec 2;129(12):5219-5235. doi: 10.1172/JCI130630.


An Hb-mediated circulating macrophage contributing to pulmonary vascular remodeling in sickle cell disease.

Redinus K, Baek JH, Yalamanoglu A, Shin HKH, Moldova R, Harral JW, Swindle D, Pak D, Ferguson SK, Nuss R, Hassell K, Nozik-Grayck E, Palmer AF, Fini MA, Karoor V, Stenmark KR, Buehler PW, Irwin DC.

JCI Insight. 2019 Aug 8;4(15). pii: 127860. doi: 10.1172/jci.insight.127860. eCollection 2019 Aug 8.


Redox states of hemoglobin determine left ventricle pressure recovery and activity of mitochondrial complex IV in hypoxic rat hearts.

Edmondson M, Jana S, Meng F, Strader MB, Baek JH, Gao Y, Buehler PW, Alayash AI.

Free Radic Biol Med. 2019 Sep;141:348-361. doi: 10.1016/j.freeradbiomed.2019.07.008. Epub 2019 Jul 11.


Attenuation of human hypoxic pulmonary vasoconstriction by acetazolamide and methazolamide.

Boulet LM, Teppema LJ, Hackett HK, Dominelli PB, Cheyne WS, Dominelli GS, Irwin DC, Buehler PW, Baek JH, Swenson ER, Foster GE.

J Appl Physiol (1985). 2018 Sep 20. doi: 10.1152/japplphysiol.00509.2018. [Epub ahead of print]


Renal Toxicodynamic Effects of Extracellular Hemoglobin After Acute Exposure.

Baek JH, Yalamanoglu A, Brown RP, Saylor DM, Malinauskas RA, Buehler PW.

Toxicol Sci. 2018 Nov 1;166(1):180-191. doi: 10.1093/toxsci/kfy193.


Depletion of haptoglobin and hemopexin promote hemoglobin-mediated lipoprotein oxidation in sickle cell disease.

Yalamanoglu A, Deuel JW, Hunt RC, Baek JH, Hassell K, Redinius K, Irwin DC, Schaer DJ, Buehler PW.

Am J Physiol Lung Cell Mol Physiol. 2018 Nov 1;315(5):L765-L774. doi: 10.1152/ajplung.00269.2018. Epub 2018 Jul 26.


Effects of living at moderate altitude on pulmonary vascular function and exercise capacity in mice with sickle cell anaemia.

Ferguson SK, Redinius K, Yalamanoglu A, Harral JW, Hyen Baek J, Pak D, Loomis Z, Hassell D, Eigenberger P, Nozik-Grayck E, Nuss R, Hassell K, Stenmark KR, Buehler PW, Irwin DC.

J Physiol. 2019 Feb;597(4):1073-1085. doi: 10.1113/JP275810. Epub 2018 Aug 25.


Phenotype-specific recombinant haptoglobin polymers co-expressed with C1r-like protein as optimized hemoglobin-binding therapeutics.

Schaer CA, Owczarek C, Deuel JW, Schauer S, Baek JH, Yalamanoglu A, Hardy MP, Scotney PD, Schmidt PM, Pelzing M, Soupourmas P, Buehler PW, Schaer DJ.

BMC Biotechnol. 2018 Mar 15;18(1):15. doi: 10.1186/s12896-018-0424-3.


Evaluation of renal oxygen homeostasis in a preclinical animal model to elucidate difference in blood quality after transfusion.

Baek JH, Yalamanoglu A, Moon SE, Gao Y, Buehler PW.

Transfusion. 2018 Jun;58(6):1474-1485. doi: 10.1111/trf.14560. Epub 2018 Mar 1.


The quaternary state of polymerized human hemoglobin regulates oxygenation of breast cancer solid tumors: A theoretical and experimental study.

Belcher DA, Ju JA, Baek JH, Yalamanoglu A, Buehler PW, Gilkes DM, Palmer AF.

PLoS One. 2018 Feb 7;13(2):e0191275. doi: 10.1371/journal.pone.0191275. eCollection 2018.


Iron accelerates hemoglobin oxidation increasing mortality in vascular diseased guinea pigs following transfusion of stored blood.

Baek JH, Yalamanoglu A, Gao Y, Guenster R, Spahn DR, Schaer DJ, Buehler PW.

JCI Insight. 2017 May 4;2(9). pii: 93577. doi: 10.1172/jci.insight.93577. eCollection 2017 May 4.


A mechanistic investigation of thrombotic microangiopathy associated with IV abuse of Opana ER.

Hunt R, Yalamanoglu A, Tumlin J, Schiller T, Baek JH, Wu A, Fogo AB, Yang H, Wong E, Miller P, Buehler PW, Kimchi-Sarfaty C.

Blood. 2017 Feb 16;129(7):896-905. doi: 10.1182/blood-2016-08-736579. Epub 2016 Nov 18.


Sodium nitrite potentiates renal oxidative stress and injury in hemoglobin exposed guinea pigs.

Baek JH, Zhang X, Williams MC, Hicks W, Buehler PW, D'Agnillo F.

Toxicology. 2015 Jul 3;333:89-99. doi: 10.1016/j.tox.2015.04.007. Epub 2015 Apr 17.


Hemoglobin-induced lung vascular oxidation, inflammation, and remodeling contribute to the progression of hypoxic pulmonary hypertension and is attenuated in rats with repeated-dose haptoglobin administration.

Irwin DC, Baek JH, Hassell K, Nuss R, Eigenberger P, Lisk C, Loomis Z, Maltzahn J, Stenmark KR, Nozik-Grayck E, Buehler PW.

Free Radic Biol Med. 2015 May;82:50-62. doi: 10.1016/j.freeradbiomed.2015.01.012. Epub 2015 Feb 2.


Reversal of hemochromatosis by apotransferrin in non-transfused and transfused Hbbth3/+ (heterozygous B1/B2 globin gene deletion) mice.

Gelderman MP, Baek JH, Yalamanoglu A, Puglia M, Vallelian F, Burla B, Vostal J, Schaer DJ, Buehler PW.

Haematologica. 2015 May;100(5):611-22. doi: 10.3324/haematol.2014.117325. Epub 2015 Jan 23.


Integrative proteome and transcriptome analysis of extramedullary erythropoiesis and its reversal by transferrin treatment in a mouse model of beta-thalassemia.

Vallelian F, Gelderman-Fuhrmann MP, Schaer CA, Puglia M, Opitz L, Baek JH, Vostal J, Buehler PW, Schaer DJ.

J Proteome Res. 2015 Feb 6;14(2):1089-100. doi: 10.1021/pr5010778. Epub 2015 Jan 23.


Modeling hemoglobin and hemoglobin:haptoglobin complex clearance in a non-rodent species-pharmacokinetic and therapeutic implications.

Boretti FS, Baek JH, Palmer AF, Schaer DJ, Buehler PW.

Front Physiol. 2014 Oct 9;5:385. doi: 10.3389/fphys.2014.00385. eCollection 2014.

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