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Items: 1 to 20 of 29


Novel 4-Acrylamido-Quinoline Derivatives as Potent PI3K/mTOR Dual Inhibitors: The Design, Synthesis, and in vitro and in vivo Biological Evaluation.

Ma X, Shen L, Zhang J, Liu G, Zhan S, Ding B, Lv X.

Front Chem. 2019 Apr 24;7:236. doi: 10.3389/fchem.2019.00236. eCollection 2019.


LRP6 Ectodomain Prevents SDF-1/CXCR4-Induced Breast Cancer Metastasis to Lung.

Zhang J, Chen J, Wo D, Yan H, Liu P, Ma E, Li L, Zheng L, Chen D, Yu Z, Liang C, Peng J, Ren DN, Zhu W.

Clin Cancer Res. 2019 Apr 22. doi: 10.1158/1078-0432.CCR-18-3557. [Epub ahead of print]


Development of a Thermoelectric and Electromagnetic Hybrid Energy Harvester from Water Flow in an Irrigation System.

Liu H, Zhang J, Shi Q, He T, Chen T, Sun L, Dziuban JA, Lee C.

Micromachines (Basel). 2018 Aug 9;9(8). pii: E395. doi: 10.3390/mi9080395.


Development of Macrocyclic Peptides Containing Epoxyketone with Oral Availability as Proteasome Inhibitors.

Li D, Zhang X, Ma X, Xu L, Yu J, Gao L, Hu X, Zhang J, Dong X, Li J, Liu T, Zhou Y, Hu Y.

J Med Chem. 2018 Oct 25;61(20):9177-9204. doi: 10.1021/acs.jmedchem.8b00819. Epub 2018 Oct 12.


Identification of novel N-acetylcysteine derivatives for the treatment of hepatocellular injury.

Liu S, Zhao Y, He R, Kong L, Xi J, Sun J, Shao Y, Pan X, Zhang J, Zhuang R.

Medchemcomm. 2017 Oct 19;8(12):2238-2247. doi: 10.1039/c7md00409e. eCollection 2017 Dec 1.


Repair of Critical-Sized Mandible Defects in Aged Rat Using Hypoxia Preconditioned BMSCs with Up-regulation of Hif-1α.

Zhang J, Feng Z, Wei J, Yu Y, Luo J, Zhou J, Li Y, Zheng X, Tang W, Liu L, Long J, Li X, Jing W.

Int J Biol Sci. 2018 Mar 11;14(4):449-460. doi: 10.7150/ijbs.24158. eCollection 2018.


Activated carbon N-acetylcysteine microcapsule protects against nonalcoholic fatty liver disease in young rats via activating telomerase and inhibiting apoptosis.

Shi T, Yang X, Zhou H, Xi J, Sun J, Ke Y, Zhang J, Shao Y, Jiang X, Pan X, Liu S, Zhuang R.

PLoS One. 2018 Jan 11;13(1):e0189856. doi: 10.1371/journal.pone.0189856. eCollection 2018.


Exploiting polypharmacology for improving therapeutic outcome of kinase inhibitors (KIs): An update of recent medicinal chemistry efforts.

Ma X, Lv X, Zhang J.

Eur J Med Chem. 2018 Jan 1;143:449-463. doi: 10.1016/j.ejmech.2017.11.049. Epub 2017 Nov 21. Review.


Synthesis and evaluation of a series of pyridine and pyrimidine derivatives as type II c-Met inhibitors.

Zhao Y, Zhang J, Zhuang R, He R, Xi J, Pan X, Shao Y, Pan J, Sun J, Cai Z, Liu S, Huang W, Lv X.

Bioorg Med Chem. 2017 Jun 15;25(12):3195-3205. doi: 10.1016/j.bmc.2017.04.003. Epub 2017 Apr 5.


Discovery of a series of N-(5-(quinolin-6-yl)pyridin-3-yl)benzenesulfonamides as PI3K/mTOR dual inhibitors.

Zhang J, Lv X, Ma X, Hu Y.

Eur J Med Chem. 2017 Feb 15;127:509-520. doi: 10.1016/j.ejmech.2017.01.016. Epub 2017 Jan 11.


Exploration of novel piperazine or piperidine constructed non-covalent peptidyl derivatives as proteasome inhibitors.

Zhuang R, Gao L, Lv X, Xi J, Sheng L, Zhao Y, He R, Hu X, Shao Y, Pan X, Liu S, Huang W, Zhou Y, Li J, Zhang J.

Eur J Med Chem. 2017 Jan 27;126:1056-1070. doi: 10.1016/j.ejmech.2016.12.034. Epub 2016 Dec 18.


Porous TiO2 Nanotubes with Spatially Separated Platinum and CoOx Cocatalysts Produced by Atomic Layer Deposition for Photocatalytic Hydrogen Production.

Zhang J, Yu Z, Gao Z, Ge H, Zhao S, Chen C, Chen S, Tong X, Wang M, Zheng Z, Qin Y.

Angew Chem Int Ed Engl. 2017 Jan 16;56(3):816-820. doi: 10.1002/anie.201611137. Epub 2016 Dec 14.


Design, synthesis and biological evaluation of novel non-covalent piperidine-containing peptidyl proteasome inhibitors.

Zhang J, Gao L, Xi J, Sheng L, Zhao Y, Xu L, Shao Y, Liu S, Zhuang R, Zhou Y, Li J.

Bioorg Med Chem. 2016 Dec 1;24(23):6206-6214. doi: 10.1016/j.bmc.2016.10.002. Epub 2016 Oct 6.


Rapid diagnosis of MDR and XDR tuberculosis with the MeltPro TB assay in China.

Pang Y, Dong H, Tan Y, Deng Y, Cai X, Jing H, Xia H, Li Q, Ou X, Su B, Li X, Zhang Z, Li J, Zhang J, Huan S, Zhao Y.

Sci Rep. 2016 May 6;6:25330. doi: 10.1038/srep25330.


Ultrathin Coating of Confined Pt Nanocatalysts by Atomic Layer Deposition for Enhanced Catalytic Performance in Hydrogenation Reactions.

Wang M, Gao Z, Zhang B, Yang H, Qiao Y, Chen S, Ge H, Zhang J, Qin Y.

Chemistry. 2016 Jun 13;22(25):8438-43. doi: 10.1002/chem.201601039. Epub 2016 May 23.


γ-Secretase inhibitor reverts the Notch signaling attenuation of osteogenic differentiation in aged bone marrow mesenchymal stem cells.

Tang Z, Wei J, Yu Y, Zhang J, Liu L, Tang W, Long J, Zheng X, Jing W.

Cell Biol Int. 2016 Apr;40(4):439-47. doi: 10.1002/cbin.10583. Epub 2016 Feb 4.


Wnt3a suppresses Wnt/β-catenin signaling and cancer cell proliferation following serum deprivation.

He Q, Yan H, Wo D, Liu J, Liu P, Zhang J, Li L, Zhou B, Ge J, Li H, Liu S, Zhu W.

Exp Cell Res. 2016 Feb 1;341(1):32-41. doi: 10.1016/j.yexcr.2015.11.025. Epub 2015 Nov 28.


Biochemical characterization of an acidophilic β-mannanase from Gloeophyllum trabeum CBS900.73 with significant transglycosylation activity and feed digesting ability.

Wang C, Zhang J, Wang Y, Niu C, Ma R, Wang Y, Bai Y, Luo H, Yao B.

Food Chem. 2016 Apr 15;197(Pt A):474-81. doi: 10.1016/j.foodchem.2015.10.115. Epub 2015 Nov 10.


LRP5/6 directly bind to Frizzled and prevent Frizzled-regulated tumour metastasis.

Ren DN, Chen J, Li Z, Yan H, Yin Y, Wo D, Zhang J, Ao L, Chen B, Ito TK, Chen Y, Liu Z, Li Y, Yang J, Lu X, Peng Y, Pan L, Zhao Y, Liu S, Zhu W.

Nat Commun. 2015 Apr 22;6:6906. doi: 10.1038/ncomms7906.


Design, synthesis and biological evaluation of novel tripeptidyl epoxyketone derivatives constructed from β-amino acid as proteasome inhibitors.

Zhang J, Cao J, Xu L, Zhou Y, Liu T, Li J, Hu Y.

Bioorg Med Chem. 2014 Jun 1;22(11):2955-65. doi: 10.1016/j.bmc.2014.04.011. Epub 2014 Apr 13.


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