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Items: 1 to 20 of 38

1.

Identification of UDP-glucuronosyltransferases involved in the metabolism of silymarin flavonolignans.

Vrba J, Papoušková B, Lněničková K, Kosina P, Křen V, Ulrichová J.

J Pharm Biomed Anal. 2020 Jan 30;178:112972. doi: 10.1016/j.jpba.2019.112972. Epub 2019 Nov 4.

PMID:
31727359
2.

Cytotoxicity of hexahelicene and its effect on the aryl hydrocarbon receptor pathway.

Vrba J, Roubalova L, Cirkva V, Storch J, Vacek J.

Toxicol In Vitro. 2019 Jun;57:105-109. doi: 10.1016/j.tiv.2019.02.020. Epub 2019 Feb 26.

PMID:
30822459
3.

Sulfated Metabolites of Flavonolignans and 2,3-Dehydroflavonolignans: Preparation and Properties.

Valentová K, Purchartová K, Rydlová L, Roubalová L, Biedermann D, Petrásková L, Křenková A, Pelantová H, Holečková-Moravcová V, Tesařová E, Cvačka J, Vrba J, Ulrichová J, Křen V.

Int J Mol Sci. 2018 Aug 9;19(8). pii: E2349. doi: 10.3390/ijms19082349.

4.

ABC Transporters and Their Role in the Neoadjuvant Treatment of Esophageal Cancer.

Vrana D, Hlavac V, Brynychova V, Vaclavikova R, Neoral C, Vrba J, Aujesky R, Matzenauer M, Melichar B, Soucek P.

Int J Mol Sci. 2018 Mar 15;19(3). pii: E868. doi: 10.3390/ijms19030868. Review.

5.

Metabolism of flavonolignans in human hepatocytes.

Vrba J, Papoušková B, Roubalová L, Zatloukalová M, Biedermann D, Křen V, Valentová K, Ulrichová J, Vacek J.

J Pharm Biomed Anal. 2018 Apr 15;152:94-101. doi: 10.1016/j.jpba.2018.01.048. Epub 2018 Jan 31.

PMID:
29414024
6.

Flavonolignan 2,3-dehydrosilydianin activates Nrf2 and upregulates NAD(P)H:quinone oxidoreductase 1 in Hepa1c1c7 cells.

Roubalová L, Dinkova-Kostova AT, Biedermann D, Křen V, Ulrichová J, Vrba J.

Fitoterapia. 2017 Jun;119:115-120. doi: 10.1016/j.fitote.2017.04.012. Epub 2017 Apr 24.

7.

Novel flavonolignan hybrid antioxidants: From enzymatic preparation to molecular rationalization.

Vavříková E, Křen V, Jezova-Kalachova L, Biler M, Chantemargue B, Pyszková M, Riva S, Kuzma M, Valentová K, Ulrichová J, Vrba J, Trouillas P, Vacek J.

Eur J Med Chem. 2017 Feb 15;127:263-274. doi: 10.1016/j.ejmech.2016.12.051. Epub 2016 Dec 26.

PMID:
28068598
8.

Semisynthetic flavonoid 7-O-galloylquercetin activates Nrf2 and induces Nrf2-dependent gene expression in RAW264.7 and Hepa1c1c7 cells.

Roubalová L, Biedermann D, Papoušková B, Vacek J, Kuzma M, Křen V, Ulrichová J, Dinkova-Kostova AT, Vrba J.

Chem Biol Interact. 2016 Dec 25;260:58-66. doi: 10.1016/j.cbi.2016.10.015. Epub 2016 Oct 21.

9.

Protective effect of isoquercitrin against acute dextran sulfate sodium-induced rat colitis depends on the severity of tissue damage.

Cibiček N, Roubalová L, Vrba J, Zatloukalová M, Ehrmann J, Zapletalová J, Večeřa R, Křen V, Ulrichová J.

Pharmacol Rep. 2016 Dec;68(6):1197-1204. doi: 10.1016/j.pharep.2016.07.007. Epub 2016 Sep 19.

PMID:
27657482
10.

Flavonolignan 2,3-dehydroderivatives: Preparation, antiradical and cytoprotective activity.

Pyszková M, Biler M, Biedermann D, Valentová K, Kuzma M, Vrba J, Ulrichová J, Sokolová R, Mojović M, Popović-Bijelić A, Kubala M, Trouillas P, Křen V, Vacek J.

Free Radic Biol Med. 2016 Jan;90:114-25. doi: 10.1016/j.freeradbiomed.2015.11.014. Epub 2015 Nov 12.

PMID:
26582372
11.

Sulfation modulates the cell uptake, antiradical activity and biological effects of flavonoids in vitro: An examination of quercetin, isoquercitrin and taxifolin.

Roubalová L, Purchartová K, Papoušková B, Vacek J, Křen V, Ulrichová J, Vrba J.

Bioorg Med Chem. 2015 Sep 1;23(17):5402-9. doi: 10.1016/j.bmc.2015.07.055. Epub 2015 Jul 29.

PMID:
26260337
12.

Metabolism of palmatine by human hepatocytes and recombinant cytochromes P450.

Vrba J, Papouskova B, Pyszkova M, Zatloukalova M, Lemr K, Ulrichova J, Vacek J.

J Pharm Biomed Anal. 2015 Jan;102:193-8. doi: 10.1016/j.jpba.2014.09.015. Epub 2014 Sep 19.

PMID:
25285405
13.

Investigation of protein FTT1103 electroactivity using carbon and mercury electrodes. Surface-inhibition approach for disulfide oxidoreductases using silver amalgam powder.

Večerková R, Hernychová L, Dobeš P, Vrba J, Josypčuk B, Bartošík M, Vacek J.

Anal Chim Acta. 2014 Jun 9;830:23-31. doi: 10.1016/j.aca.2014.04.056. Epub 2014 May 2.

PMID:
24856508
14.

Isoquercitrin: pharmacology, toxicology, and metabolism.

Valentová K, Vrba J, Bancířová M, Ulrichová J, Křen V.

Food Chem Toxicol. 2014 Jun;68:267-82. doi: 10.1016/j.fct.2014.03.018. Epub 2014 Mar 27. Review.

PMID:
24680690
15.

Palmatine activates AhR and upregulates CYP1A activity in HepG2 cells but not in human hepatocytes.

Vrba J, Havlikova M, Gerhardova D, Ulrichova J.

Toxicol In Vitro. 2014 Jun;28(4):693-9. doi: 10.1016/j.tiv.2014.02.008. Epub 2014 Feb 27.

PMID:
24583342
16.

LC-MS metabolic study on quercetin and taxifolin galloyl esters using human hepatocytes as toxicity and biotransformation in vitro cell model.

Vacek J, Papoušková B, Vrba J, Zatloukalová M, Křen V, Ulrichová J.

J Pharm Biomed Anal. 2013 Dec;86:135-42. doi: 10.1016/j.jpba.2013.07.045. Epub 2013 Aug 14.

PMID:
24008144
17.

A novel semisynthetic flavonoid 7-O-galloyltaxifolin upregulates heme oxygenase-1 in RAW264.7 cells via MAPK/Nrf2 pathway.

Vrba J, Gažák R, Kuzma M, Papoušková B, Vacek J, Weiszenstein M, Křen V, Ulrichová J.

J Med Chem. 2013 Feb 14;56(3):856-66. doi: 10.1021/jm3013344. Epub 2013 Jan 18.

PMID:
23294286
18.

Biotransformation of flavonols and taxifolin in hepatocyte in vitro systems as determined by liquid chromatography with various stationary phases and electrospray ionization-quadrupole time-of-flight mass spectrometry.

Vacek J, Papoušková B, Kosina P, Vrba J, Křen V, Ulrichová J.

J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Jun 15;899:109-15. doi: 10.1016/j.jchromb.2012.05.009. Epub 2012 May 14.

PMID:
22664057
19.

Quercetin, quercetin glycosides and taxifolin differ in their ability to induce AhR activation and CYP1A1 expression in HepG2 cells.

Vrba J, Kren V, Vacek J, Papouskova B, Ulrichova J.

Phytother Res. 2012 Nov;26(11):1746-52. doi: 10.1002/ptr.4637. Epub 2012 Mar 15.

PMID:
22422552
20.

HDAC inhibitors sodium butyrate and sodium valproate do not affect human ncor1 and ncor2 gene expression in HL-60 cells.

Vrba J, Trtkova K, Ulrichova J.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2011 Sep;155(3):259-62. doi: 10.5507/bp.2011.033.

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