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J Funct Biomater. 2016 Jul 12;7(3). pii: E18. doi: 10.3390/jfb7030018.

Effect of Nanoparticle Incorporation and Surface Coating on Mechanical Properties of Bone Scaffolds: A Brief Review.

Author information

1
Department of Mechanical Engineering, University of Saskatchewan, 57 Campus Drive, Saskatoon, SK S7H 5A9, Canada. jec489@mail.usask.ca.
2
Department of Mechanical Engineering, University of Saskatchewan, 57 Campus Drive, Saskatoon, SK S7H 5A9, Canada. xbc719@mail.usask.ca.
3
Division of Biomedical Engineering, University of Saskatchewan, 57 Campus Drive, Saskatoon, SK S7H 5A9, Canada. xbc719@mail.usask.ca.
4
Department of Mechanical Engineering, University of Saskatchewan, 57 Campus Drive, Saskatoon, SK S7H 5A9, Canada. qiaoqin.yang@usask.ca.
5
Division of Biomedical Engineering, University of Saskatchewan, 57 Campus Drive, Saskatoon, SK S7H 5A9, Canada. qiaoqin.yang@usask.ca.

Abstract

Mechanical properties of a scaffold play an important role in its in vivo performance in bone tissue engineering, due to the fact that implanted scaffolds are typically subjected to stress including compression, tension, torsion, and shearing. Unfortunately, not all the materials used to fabricate scaffolds are strong enough to mimic native bones. Extensive research has been conducted in order to increase scaffold strength and mechanical performance by incorporating nanoparticles and/or coatings. An incredible improvement has been achieved; and some outstanding examples are the usage of nanodiamond, hydroxyapatite, bioactive glass particles, SiO₂, MgO, and silver nanoparticles. This review paper aims to present the results, to summarize significant findings, and to give perspective for future work, which could be beneficial to future bone tissue engineering.

KEYWORDS:

bioactive glass particles; biomaterials; hydroxyapatite; mechanical properties; nanodiamond; scaffold design; scaffold fabrication; silver nanoparticles; surface coating; tissue engineering

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