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Items: 1 to 20 of 50

1.

Development of a new largely scalable in vitro prion propagation method for the production of infectious recombinant prions for high resolution structural studies.

Eraña H, Charco JM, Di Bari MA, Díaz-Domínguez CM, López-Moreno R, Vidal E, González-Miranda E, Pérez-Castro MA, García-Martínez S, Bravo S, Fernández-Borges N, Geijo M, D'Agostino C, Garrido J, Bian J, König A, Uluca-Yazgi B, Sabate R, Khaychuk V, Vanni I, Telling GC, Heise H, Nonno R, Requena JR, Castilla J.

PLoS Pathog. 2019 Oct 23;15(10):e1008117. doi: 10.1371/journal.ppat.1008117. eCollection 2019 Oct.

2.

Full atomistic model of prion structure and conversion.

Spagnolli G, Rigoli M, Orioli S, Sevillano AM, Faccioli P, Wille H, Biasini E, Requena JR.

PLoS Pathog. 2019 Jul 11;15(7):e1007864. doi: 10.1371/journal.ppat.1007864. eCollection 2019 Jul.

3.

Ok Google, how could I design therapeutics against prion diseases?

Rigoli M, Spagnolli G, Faccioli P, Requena JR, Biasini E.

Curr Opin Pharmacol. 2019 Feb;44:39-45. doi: 10.1016/j.coph.2019.03.015. Epub 2019 May 3. Review.

PMID:
31059982
4.

The prion 2018 round tables (I): the structure of PrPSc.

Baskakov IV, Caughey B, Requena JR, Sevillano AM, Surewicz WK, Wille H.

Prion. 2019 Jan;13(1):46-52. doi: 10.1080/19336896.2019.1569450.

5.

Proteomic Studies Reveal Disrupted in Schizophrenia 1 as a Player in Both Neurodevelopment and Synaptic Function.

Ramos A, Rodríguez-Seoane C, Rosa I, Gorroño-Etxebarria I, Alonso J, Veiga S, Korth C, Kypta RM, García Á, Requena JR.

Int J Mol Sci. 2018 Dec 29;20(1). pii: E119. doi: 10.3390/ijms20010119.

6.

The Structure of PrPSc Prions.

Wille H, Requena JR.

Pathogens. 2018 Feb 7;7(1). pii: E20. doi: 10.3390/pathogens7010020. Review.

7.

Recombinant PrPSc shares structural features with brain-derived PrPSc: Insights from limited proteolysis.

Sevillano AM, Fernández-Borges N, Younas N, Wang F, R Elezgarai S, Bravo S, Vázquez-Fernández E, Rosa I, Eraña H, Gil D, Veiga S, Vidal E, Erickson-Beltran ML, Guitián E, Silva CJ, Nonno R, Ma J, Castilla J, R Requena J.

PLoS Pathog. 2018 Jan 31;14(1):e1006797. doi: 10.1371/journal.ppat.1006797. eCollection 2018 Jan.

8.

Determining the Relative Susceptibility of Four Prion Protein Genotypes to Atypical Scrapie.

Silva CJ, Erickson-Beltran ML, Martín-Burriel I, Badiola JJ, Requena JR, Bolea R.

Anal Chem. 2018 Jan 16;90(2):1255-1262. doi: 10.1021/acs.analchem.7b03985. Epub 2018 Jan 2.

PMID:
29240410
9.

Cofactors influence the biological properties of infectious recombinant prions.

Fernández-Borges N, Di Bari MA, Eraña H, Sánchez-Martín M, Pirisinu L, Parra B, Elezgarai SR, Vanni I, López-Moreno R, Vaccari G, Venegas V, Charco JM, Gil D, Harrathi C, D'Agostino C, Agrimi U, Mayoral T, Requena JR, Nonno R, Castilla J.

Acta Neuropathol. 2018 Feb;135(2):179-199. doi: 10.1007/s00401-017-1782-y. Epub 2017 Nov 1.

PMID:
29094186
10.

The human VGF-derived bioactive peptide TLQP-21 binds heat shock 71 kDa protein 8 (HSPA8)on the surface of SH-SY5Y cells.

Akhter S, Chakraborty S, Moutinho D, Álvarez-Coiradas E, Rosa I, Viñuela J, Domínguez E, García A, Requena JR.

PLoS One. 2017 Sep 21;12(9):e0185176. doi: 10.1371/journal.pone.0185176. eCollection 2017.

11.

Generation of a new infectious recombinant prion: a model to understand Gerstmann-Sträussler-Scheinker syndrome.

Elezgarai SR, Fernández-Borges N, Eraña H, Sevillano AM, Charco JM, Harrathi C, Saá P, Gil D, Kong Q, Requena JR, Andréoletti O, Castilla J.

Sci Rep. 2017 Aug 29;7(1):9584. doi: 10.1038/s41598-017-09489-3.

12.

The Structure of the Infectious Prion Protein and Its Propagation.

Requena JR, Wille H.

Prog Mol Biol Transl Sci. 2017;150:341-359. doi: 10.1016/bs.pmbts.2017.06.009. Epub 2017 Jul 31. Review.

PMID:
28838667
13.

An antipsychotic drug exerts anti-prion effects by altering the localization of the cellular prion protein.

Stincardini C, Massignan T, Biggi S, Elezgarai SR, Sangiovanni V, Vanni I, Pancher M, Adami V, Moreno J, Stravalaci M, Maietta G, Gobbi M, Negro A, Requena JR, Castilla J, Nonno R, Biasini E.

PLoS One. 2017 Aug 7;12(8):e0182589. doi: 10.1371/journal.pone.0182589. eCollection 2017.

14.

Elucidating the structure of an infectious protein.

Zweckstetter M, Requena JR, Wille H.

PLoS Pathog. 2017 Apr 13;13(4):e1006229. doi: 10.1371/journal.ppat.1006229. eCollection 2017 Apr. Review. No abstract available.

15.

Quantitating PrP Polymorphisms Present in Prions from Heterozygous Scrapie-Infected Sheep.

Silva CJ, Erickson-Beltran ML, Hui C, Badiola JJ, Nicholson EM, Requena JR, Bolea R.

Anal Chem. 2017 Jan 3;89(1):854-861. doi: 10.1021/acs.analchem.6b03822. Epub 2016 Dec 21.

PMID:
27936597
16.

The Structural Architecture of an Infectious Mammalian Prion Using Electron Cryomicroscopy.

Vázquez-Fernández E, Vos MR, Afanasyev P, Cebey L, Sevillano AM, Vidal E, Rosa I, Renault L, Ramos A, Peters PJ, Fernández JJ, van Heel M, Young HS, Requena JR, Wille H.

PLoS Pathog. 2016 Sep 8;12(9):e1005835. doi: 10.1371/journal.ppat.1005835. eCollection 2016 Sep.

17.

The Priority position paper: Protecting Europe's food chain from prions.

Requena JR, Kristensson K, Korth C, Zurzolo C, Simmons M, Aguilar-Calvo P, Aguzzi A, Andreoletti O, Benestad SL, Böhm R, Brown K, Calgua B, Del Río JA, Espinosa JC, Girones R, Godsave S, Hoelzle LE, Knittler MR, Kuhn F, Legname G, Laeven P, Mabbott N, Mitrova E, Müller-Schiffmann A, Nuvolone M, Peters PJ, Raeber A, Roth K, Schmitz M, Schroeder B, Sonati T, Stitz L, Taraboulos A, Torres JM, Yan ZX, Zerr I.

Prion. 2016 May 3;10(3):165-81. doi: 10.1080/19336896.2016.1175801.

18.

Larger aggregates of mutant seipin in Celia's Encephalopathy, a new protein misfolding neurodegenerative disease.

Ruiz-Riquelme A, Sánchez-Iglesias S, Rábano A, Guillén-Navarro E, Domingo-Jiménez R, Ramos A, Rosa I, Senra A, Nilsson P, García Á, Araújo-Vilar D, Requena JR.

Neurobiol Dis. 2015 Nov;83:44-53. doi: 10.1016/j.nbd.2015.08.006. Epub 2015 Aug 15.

PMID:
26282322
19.

DISC1 regulates expression of the neurotrophin VGF through the PI3K/AKT/CREB pathway.

Rodríguez-Seoane C, Ramos A, Korth C, Requena JR.

J Neurochem. 2015 Nov;135(3):598-605. doi: 10.1111/jnc.13258. Epub 2015 Aug 12.

20.

Prion-like diseases: Looking for their niche in the realm of infectious diseases.

Castilla J, Requena JR.

Virus Res. 2015 Sep 2;207:1-4. doi: 10.1016/j.virusres.2015.06.001. Epub 2015 Jun 4. No abstract available.

PMID:
26052085

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