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p53 reactivation with induction of massive apoptosis-1 (PRIMA-1) inhibits amyloid aggregation of mutant p53 in cancer cells.

Rangel LP, Ferretti GDS, Costa CL, Andrade SMMV, Carvalho RS, Costa DCF, Silva JL.

J Biol Chem. 2019 Jan 2. pii: jbc.RA118.004671. doi: 10.1074/jbc.RA118.004671. [Epub ahead of print]


In Vitro Prion Amplification Methodology for Inhibitor Screening.

Vieira TCRG, Silva JL.

Methods Mol Biol. 2019;1873:305-316. doi: 10.1007/978-1-4939-8820-4_20.


Methods to Screen Compounds Against Mutant p53 Misfolding and Aggregation for Cancer Therapeutics.

Ferretti GDDS, da Costa DCF, L Silva J, Pereira Rangel L.

Methods Mol Biol. 2019;1873:265-277. doi: 10.1007/978-1-4939-8820-4_17.


Resveratrol prevents p53 aggregation in vitro and in breast cancer cells.

Ferraz da Costa DC, Campos NPC, Santos RA, Guedes-da-Silva FH, Martins-Dinis MMDC, Zanphorlin L, Ramos C, Rangel LP, Silva JL.

Oncotarget. 2018 Jun 26;9(49):29112-29122. doi: 10.18632/oncotarget.25631. eCollection 2018 Jun 26.


Aggregation-primed molten globule conformers of the p53 core domain provide potential tools for studying p53C aggregation in cancer.

Pedrote MM, de Oliveira GAP, Felix AL, Mota MF, Marques MA, Soares IN, Iqbal A, Norberto DR, Gomes AMO, Gratton E, Cino EA, Silva JL.

J Biol Chem. 2018 Jul 20;293(29):11374-11387. doi: 10.1074/jbc.RA118.003285. Epub 2018 May 31.


Targeting the Prion-like Aggregation of Mutant p53 to Combat Cancer.

Silva JL, Cino EA, Soares IN, Ferreira VF, A P de Oliveira G.

Acc Chem Res. 2018 Jan 16;51(1):181-190. doi: 10.1021/acs.accounts.7b00473. Epub 2017 Dec 20.


Cancer Chemoprevention by Resveratrol: The p53 Tumor Suppressor Protein as a Promising Molecular Target.

Ferraz da Costa DC, Fialho E, Silva JL.

Molecules. 2017 Jun 18;22(6). pii: E1014. doi: 10.3390/molecules22061014. Review.


Distinct modulatory role of RNA in the aggregation of the tumor suppressor protein p53 core domain.

Kovachev PS, Banerjee D, Rangel LP, Eriksson J, Pedrote MM, Martins-Dinis MMDC, Edwards K, Cordeiro Y, Silva JL, Sanyal S.

J Biol Chem. 2017 Jun 2;292(22):9345-9357. doi: 10.1074/jbc.M116.762096. Epub 2017 Apr 18.


Stability of different influenza subtypes: How can high hydrostatic pressure be a useful tool for vaccine development?

Dumard CH, Barroso SPC, Santos ACV, Alves NS, Couceiro JNSS, Gomes AMO, Santos PS, Silva JL, Oliveira AC.

Biophys Chem. 2017 Dec;231:116-124. doi: 10.1016/j.bpc.2017.04.002. Epub 2017 Apr 6.


Amide hydrogens reveal a temperature-dependent structural transition that enhances site-II Ca2+-binding affinity in a C-domain mutant of cardiac troponin C.

Veltri T, de Oliveira GAP, Bienkiewicz EA, Palhano FL, Marques MA, Moraes AH, Silva JL, Sorenson MM, Pinto JR.

Sci Rep. 2017 Apr 6;7(1):691. doi: 10.1038/s41598-017-00777-6.


The push-and-pull hypothesis in protein unfolding, misfolding and aggregation.

de Oliveira GAP, Silva JL.

Biophys Chem. 2017 Dec;231:20-26. doi: 10.1016/j.bpc.2017.03.007. Epub 2017 Mar 29.


Allosteric Transmission along a Loosely Structured Backbone Allows a Cardiac Troponin C Mutant to Function with Only One Ca2+ Ion.

Marques MA, Pinto JR, Moraes AH, Iqbal A, de Magalhães MT, Monteiro J, Pedrote MM, Sorenson MM, Silva JL, de Oliveira GA.

J Biol Chem. 2017 Feb 10;292(6):2379-2394. doi: 10.1074/jbc.M116.765362. Epub 2017 Jan 3.


Structural basis for the dissociation of α-synuclein fibrils triggered by pressure perturbation of the hydrophobic core.

de Oliveira GA, Marques MA, Cruzeiro-Silva C, Cordeiro Y, Schuabb C, Moraes AH, Winter R, Oschkinat H, Foguel D, Freitas MS, Silva JL.

Sci Rep. 2016 Nov 30;6:37990. doi: 10.1038/srep37990.


Aggregation tendencies in the p53 family are modulated by backbone hydrogen bonds.

Cino EA, Soares IN, Pedrote MM, de Oliveira GA, Silva JL.

Sci Rep. 2016 Sep 7;6:32535. doi: 10.1038/srep32535.


Regulation of Amyloid β Oligomer Binding to Neurons and Neurotoxicity by the Prion Protein-mGluR5 Complex.

Beraldo FH, Ostapchenko VG, Caetano FA, Guimaraes AL, Ferretti GD, Daude N, Bertram L, Nogueira KO, Silva JL, Westaway D, Cashman NR, Martins VR, Prado VF, Prado MA.

J Biol Chem. 2016 Oct 14;291(42):21945-21955. Epub 2016 Aug 25.


Aggregation and Prion-Like Properties of Misfolded Tumor Suppressors: Is Cancer a Prion Disease?

Costa DC, de Oliveira GA, Cino EA, Soares IN, Rangel LP, Silva JL.

Cold Spring Harb Perspect Biol. 2016 Oct 3;8(10). pii: a023614. doi: 10.1101/cshperspect.a023614. Review.


The "Jekyll and Hyde" Actions of Nucleic Acids on the Prion-like Aggregation of Proteins.

Silva JL, Cordeiro Y.

J Biol Chem. 2016 Jul 22;291(30):15482-90. doi: 10.1074/jbc.R116.733428. Epub 2016 Jun 10. Review.


Backbone resonance assignments of the human p73 DNA binding domain.

Cino EA, Soares IN, Freitas MS, Silva JL.

Biomol NMR Assign. 2016 Apr;10(1):49-51. doi: 10.1007/s12104-015-9635-x. Epub 2015 Aug 21.


Pressure-Inactivated Virus: A Promising Alternative for Vaccine Production.

Silva JL, Barroso SP, Mendes YS, Dumard CH, Santos PS, Gomes AM, Oliveira AC.

Subcell Biochem. 2015;72:301-18. doi: 10.1007/978-94-017-9918-8_15.


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