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Items: 1 to 20 of 82

1.

Snake Venom Gland Organoids.

Post Y, Puschhof J, Beumer J, Kerkkamp HM, de Bakker MAG, Slagboom J, de Barbanson B, Wevers NR, Spijkers XM, Olivier T, Kazandjian TD, Ainsworth S, Iglesias CL, van de Wetering WJ, Heinz MC, van Ineveld RL, van Kleef RGDM, Begthel H, Korving J, Bar-Ephraim YE, Getreuer W, Rios AC, Westerink RHS, Snippert HJG, van Oudenaarden A, Peters PJ, Vonk FJ, Kool J, Richardson MK, Casewell NR, Clevers H.

Cell. 2020 Jan 23;180(2):233-247.e21. doi: 10.1016/j.cell.2019.11.038.

PMID:
31978343
2.

Antivenom Neutralization of Coagulopathic Snake Venom Toxins Assessed by Bioactivity Profiling Using Nanofractionation Analytics.

Xie C, Slagboom J, Albulescu LO, Bruyneel B, Still KBM, Vonk FJ, Somsen GW, Casewell NR, Kool J.

Toxins (Basel). 2020 Jan 16;12(1). pii: E53. doi: 10.3390/toxins12010053.

3.

Solenodon genome reveals convergent evolution of venom in eulipotyphlan mammals.

Casewell NR, Petras D, Card DC, Suranse V, Mychajliw AM, Richards D, Koludarov I, Albulescu LO, Slagboom J, Hempel BF, Ngum NM, Kennerley RJ, Brocca JL, Whiteley G, Harrison RA, Bolton FMS, Debono J, Vonk FJ, Alföldi J, Johnson J, Karlsson EK, Lindblad-Toh K, Mellor IR, Süssmuth RD, Fry BG, Kuruppu S, Hodgson WC, Kool J, Castoe TA, Barnes I, Sunagar K, Undheim EAB, Turvey ST.

Proc Natl Acad Sci U S A. 2019 Dec 17;116(51):25745-25755. doi: 10.1073/pnas.1906117116. Epub 2019 Nov 26.

4.

Identification of mutagenic and endocrine disrupting compounds in surface water and wastewater treatment plant effluents using high-resolution effect-directed analysis.

Zwart N, Jonker W, Broek RT, de Boer J, Somsen G, Kool J, Hamers T, Houtman CJ, Lamoree MH.

Water Res. 2020 Jan 1;168:115204. doi: 10.1016/j.watres.2019.115204. Epub 2019 Oct 16.

5.

Analytics for Bioactivity Profiling of Complex Mixtures with a Focus on Venoms.

Mladic M, Niessen WMA, Somsen GW, Kool J.

Methods Mol Biol. 2020;2068:27-49. doi: 10.1007/978-1-4939-9845-6_2.

PMID:
31576521
6.

A Decoy-Receptor Approach Using Nicotinic Acetylcholine Receptor Mimics Reveals Their Potential as Novel Therapeutics Against Neurotoxic Snakebite.

Albulescu LO, Kazandjian T, Slagboom J, Bruyneel B, Ainsworth S, Alsolaiss J, Wagstaff SC, Whiteley G, Harrison RA, Ulens C, Kool J, Casewell NR.

Front Pharmacol. 2019 Jul 30;10:848. doi: 10.3389/fphar.2019.00848. eCollection 2019.

7.

Bioactivity Profiling of Small-Volume Samples by Nano Liquid Chromatography Coupled to Microarray Bioassaying Using High-Resolution Fractionation.

Zietek BM, Still KBM, Jaschusch K, Bruyneel B, Ariese F, Brouwer TJF, Luger M, Limburg RJ, Rosier JC, V Iperen DJ, Casewell NR, Somsen GW, Kool J.

Anal Chem. 2019 Aug 20;91(16):10458-10466. doi: 10.1021/acs.analchem.9b01261. Epub 2019 Aug 2.

8.

Compound Identification Using Liquid Chromatography and High-Resolution Noncontact Fraction Collection with a Solenoid Valve.

Jonker W, de Vries K, Althuisius N, van Iperen D, Janssen E, Ten Broek R, Houtman C, Zwart N, Hamers T, Lamoree MH, Ooms B, Hidding J, Somsen GW, Kool J.

SLAS Technol. 2019 Dec;24(6):543-555. doi: 10.1177/2472630319848768. Epub 2019 May 16.

9.

Drug Discovery on Natural Products: From Ion Channels to nAChRs, from Nature to Libraries, from Analytics to Assays.

Otvos RA, Still KBM, Somsen GW, Smit AB, Kool J.

SLAS Discov. 2019 Mar;24(3):362-385. doi: 10.1177/2472555218822098. Epub 2019 Jan 25.

10.

Affinity profiling of monoclonal antibody and antibody-drug-conjugate preparations by coupled liquid chromatography-surface plasmon resonance biosensing.

Lakayan D, Haselberg R, Gahoual R, Somsen GW, Kool J.

Anal Bioanal Chem. 2018 Dec;410(30):7837-7848. doi: 10.1007/s00216-018-1414-y. Epub 2018 Oct 17.

11.

The paraspecific neutralisation of snake venom induced coagulopathy by antivenoms.

Ainsworth S, Slagboom J, Alomran N, Pla D, Alhamdi Y, King SI, Bolton FMS, Gutiérrez JM, Vonk FJ, Toh CH, Calvete JJ, Kool J, Harrison RA, Casewell NR.

Commun Biol. 2018 Apr 19;1:34. doi: 10.1038/s42003-018-0039-1. eCollection 2018.

12.

Detection and identification of antibacterial proteins in snake venoms using at-line nanofractionation coupled to LC-MS.

Mladic M, Slagboom J, Kool J, Vonk FJ, van Wezel GP, Richardson MK.

Toxicon. 2018 Dec 1;155:66-74. doi: 10.1016/j.toxicon.2018.08.009. Epub 2018 Aug 31.

PMID:
30172790
13.

Liquid chromatographic nanofractionation with parallel mass spectrometric detection for the screening of plasmin inhibitors and (metallo)proteinases in snake venoms.

Zietek BM, Mayar M, Slagboom J, Bruyneel B, Vonk FJ, Somsen GW, Casewell NR, Kool J.

Anal Bioanal Chem. 2018 Sep;410(23):5751-5763. doi: 10.1007/s00216-018-1253-x. Epub 2018 Aug 9.

14.

Rapid ligand fishing for identification of acetylcholinesterase-binding peptides in snake venom reveals new properties of dendrotoxins.

Vanzolini KL, Ainsworth S, Bruyneel B, Herzig V, Seraus MGL, Somsen GW, Casewell NR, Cass QB, Kool J.

Toxicon. 2018 Sep 15;152:1-8. doi: 10.1016/j.toxicon.2018.06.080. Epub 2018 Jul 7.

15.

Online screening of acetylcholinesterase inhibitors in natural products using monolith-based immobilized capillary enzyme reactors combined with liquid chromatography-mass spectrometry.

Wang L, Zhao Y, Zhang Y, Zhang T, Kool J, Somsen GW, Wang Q, Jiang Z.

J Chromatogr A. 2018 Aug 17;1563:135-143. doi: 10.1016/j.chroma.2018.05.069. Epub 2018 May 30.

PMID:
29866504
16.

Whole snake venoms: Cytotoxic, anti-metastatic and antiangiogenic properties.

Kerkkamp H, Bagowski C, Kool J, van Soolingen B, Vonk FJ, Vlecken D.

Toxicon. 2018 Aug;150:39-49. doi: 10.1016/j.toxicon.2018.05.004. Epub 2018 May 12.

17.

Neurotoxicity fingerprinting of venoms using on-line microfluidic AChBP profiling.

Slagboom J, Otvos RA, Cardoso FC, Iyer J, Visser JC, van Doodewaerd BR, McCleary RJR, Niessen WMA, Somsen GW, Lewis RJ, Kini RM, Smit AB, Casewell NR, Kool J.

Toxicon. 2018 Jun 15;148:213-222. doi: 10.1016/j.toxicon.2018.04.022. Epub 2018 May 4.

18.

High-Throughput Effect-Directed Analysis Using Downscaled in Vitro Reporter Gene Assays To Identify Endocrine Disruptors in Surface Water.

Zwart N, Nio SL, Houtman CJ, de Boer J, Kool J, Hamers T, Lamoree MH.

Environ Sci Technol. 2018 Apr 3;52(7):4367-4377. doi: 10.1021/acs.est.7b06604. Epub 2018 Mar 26.

19.

Nanofractionation Platform with Parallel Mass Spectrometry for Identification of CYP1A2 Inhibitors in Metabolic Mixtures.

Zietek BM, Mladic M, Bruyneel B, Niessen WMA, Honing M, Somsen GW, Kool J.

SLAS Discov. 2018 Mar;23(3):283-293. doi: 10.1177/2472555217746323. Epub 2017 Dec 21.

PMID:
29262760
20.

Development of a luminescent mutagenicity test for high-throughput screening of aquatic samples.

Zwart N, Lamoree MH, Houtman CJ, de Boer J, Kool J, Hamers T.

Toxicol In Vitro. 2018 Feb;46:350-360. doi: 10.1016/j.tiv.2017.09.005. Epub 2017 Sep 6.

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