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A viral kinase counteracts in vivo restriction of murine cytomegalovirus by SAMHD1.

Deutschmann J, Schneider A, Gruska I, Vetter B, Thomas D, Kießling M, Wittmann S, Herrmann A, Schindler M, Milbradt J, Ferreirós N, Winkler TH, Wiebusch L, Gramberg T.

Nat Microbiol. 2019 Dec;4(12):2273-2284. doi: 10.1038/s41564-019-0529-z. Epub 2019 Sep 23.


Human cytomegalovirus overcomes SAMHD1 restriction in macrophages via pUL97.

Businger R, Deutschmann J, Gruska I, Milbradt J, Wiebusch L, Gramberg T, Schindler M.

Nat Microbiol. 2019 Dec;4(12):2260-2272. doi: 10.1038/s41564-019-0557-8. Epub 2019 Sep 23.


Human cytomegalovirus utilises cellular dual-specificity tyrosine phosphorylation-regulated kinases during placental replication.

Hamilton ST, Hutterer C, Egilmezer E, Steingruber M, Milbradt J, Marschall M, Rawlinson WD.

Placenta. 2018 Dec;72-73:10-19. doi: 10.1016/j.placenta.2018.10.002. Epub 2018 Oct 13.


Transmembrane Protein pUL50 of Human Cytomegalovirus Inhibits ISGylation by Downregulating UBE1L.

Lee MK, Kim YJ, Kim YE, Han TH, Milbradt J, Marschall M, Ahn JH.

J Virol. 2018 Jul 17;92(15). pii: e00462-18. doi: 10.1128/JVI.00462-18. Print 2018 Aug 1.


Human Cytomegalovirus Nuclear Capsids Associate with the Core Nuclear Egress Complex and the Viral Protein Kinase pUL97.

Milbradt J, Sonntag E, Wagner S, Strojan H, Wangen C, Lenac Rovis T, Lisnic B, Jonjic S, Sticht H, Britt WJ, Schlötzer-Schrehardt U, Marschall M.

Viruses. 2018 Jan 13;10(1). pii: E35. doi: 10.3390/v10010035.


Protein kinases responsible for the phosphorylation of the nuclear egress core complex of human cytomegalovirus.

Sonntag E, Milbradt J, Svrlanska A, Strojan H, Häge S, Kraut A, Hesse AM, Amin B, Sonnewald U, Couté Y, Marschall M.

J Gen Virol. 2017 Oct;98(10):2569-2581. doi: 10.1099/jgv.0.000931. Epub 2017 Sep 27.


The human cytomegalovirus nuclear egress complex unites multiple functions: Recruitment of effectors, nuclear envelope rearrangement, and docking to nuclear capsids.

Marschall M, Muller YA, Diewald B, Sticht H, Milbradt J.

Rev Med Virol. 2017 Jul;27(4). doi: 10.1002/rmv.1934. Epub 2017 Jun 30. Review.


Inhibitors of dual-specificity tyrosine phosphorylation-regulated kinases (DYRK) exert a strong anti-herpesviral activity.

Hutterer C, Milbradt J, Hamilton S, Zaja M, Leban J, Henry C, Vitt D, Steingruber M, Sonntag E, Zeitträger I, Bahsi H, Stamminger T, Rawlinson W, Strobl S, Marschall M.

Antiviral Res. 2017 Jul;143:113-121. doi: 10.1016/j.antiviral.2017.04.003. Epub 2017 Apr 9.


Erratum to Cytomegalovirus pUL50 is the multi-interacting determinant of the core nuclear egress complex (NEC) that recruits cellular accessory NEC components.

Sonntag E, Hamilton ST, Bahsi H, Wagner S, Jonjic S, Rawlinson WD, Marschall M, Milbradt J.

J Gen Virol. 2016 Sep;97(9):2461. doi: 10.1099/jgv.0.000599. No abstract available.


The Prolyl Isomerase Pin1 Promotes the Herpesvirus-Induced Phosphorylation-Dependent Disassembly of the Nuclear Lamina Required for Nucleocytoplasmic Egress.

Milbradt J, Hutterer C, Bahsi H, Wagner S, Sonntag E, Horn AH, Kaufer BB, Mori Y, Sticht H, Fossen T, Marschall M.

PLoS Pathog. 2016 Aug 24;12(8):e1005825. doi: 10.1371/journal.ppat.1005825. eCollection 2016 Aug.


Cytomegalovirus pUL50 is the multi-interacting determinant of the core nuclear egress complex (NEC) that recruits cellular accessory NEC components.

Sonntag E, Hamilton ST, Bahsi H, Wagner S, Jonjic S, Rawlinson WD, Marschall M, Milbradt J.

J Gen Virol. 2016 Jul;97(7):1676-1685. doi: 10.1099/jgv.0.000495. Epub 2016 May 4. Erratum in: J Gen Virol. 2016 Sep;97(9):2461.


Human Cytomegalovirus Nuclear Egress Proteins Ectopically Expressed in the Heterologous Environment of Plant Cells are Strictly Targeted to the Nuclear Envelope.

Lamm CE, Link K, Wagner S, Milbradt J, Marschall M, Sonnewald U.

Viruses. 2016 Mar 10;8(3):73. doi: 10.3390/v8030073.


New insight into the phosphorylation-regulated intranuclear localization of human cytomegalovirus pUL69 mediated by cyclin-dependent kinases (CDKs) and viral CDK orthologue pUL97.

Graf L, Feichtinger S, Naing Z, Hutterer C, Milbradt J, Webel R, Wagner S, Scott GM, Hamilton ST, Rawlinson WD, Stamminger T, Thomas M, Marschall M.

J Gen Virol. 2016 Jan;97(1):144-151. doi: 10.1099/jgv.0.000337. Epub 2015 Nov 6.


The broad-spectrum antiinfective drug artesunate interferes with the canonical nuclear factor kappa B (NF-κB) pathway by targeting RelA/p65.

Hutterer C, Niemann I, Milbradt J, Fröhlich T, Reiter C, Kadioglu O, Bahsi H, Zeitträger I, Wagner S, Einsiedel J, Gmeiner P, Vogel N, Wandinger S, Godl K, Stamminger T, Efferth T, Tsogoeva SB, Marschall M.

Antiviral Res. 2015 Dec;124:101-9. doi: 10.1016/j.antiviral.2015.10.003. Epub 2015 Nov 4.


Crystal Structure of the Human Cytomegalovirus pUL50-pUL53 Core Nuclear Egress Complex Provides Insight into a Unique Assembly Scaffold for Virus-Host Protein Interactions.

Walzer SA, Egerer-Sieber C, Sticht H, Sevvana M, Hohl K, Milbradt J, Muller YA, Marschall M.

J Biol Chem. 2015 Nov 13;290(46):27452-8. doi: 10.1074/jbc.C115.686527. Epub 2015 Oct 2.


A novel CDK7 inhibitor of the Pyrazolotriazine class exerts broad-spectrum antiviral activity at nanomolar concentrations.

Hutterer C, Eickhoff J, Milbradt J, Korn K, Zeitträger I, Bahsi H, Wagner S, Zischinsky G, Wolf A, Degenhart C, Unger A, Baumann M, Klebl B, Marschall M.

Antimicrob Agents Chemother. 2015 Apr;59(4):2062-71. doi: 10.1128/AAC.04534-14. Epub 2015 Jan 26.


Proteomic analysis of the multimeric nuclear egress complex of human cytomegalovirus.

Milbradt J, Kraut A, Hutterer C, Sonntag E, Schmeiser C, Ferro M, Wagner S, Lenac T, Claus C, Pinkert S, Hamilton ST, Rawlinson WD, Sticht H, Couté Y, Marschall M.

Mol Cell Proteomics. 2014 Aug;13(8):2132-46. doi: 10.1074/mcp.M113.035782. Epub 2014 Jun 26.


Human cytomegalovirus replication is strictly inhibited by siRNAs targeting UL54, UL97 or UL122/123 gene transcripts.

Hamilton ST, Milbradt J, Marschall M, Rawlinson WD.

PLoS One. 2014 Jun 2;9(6):e97231. doi: 10.1371/journal.pone.0097231. eCollection 2014.


The cytomegalovirus egress proteins pUL50 and pUL53 are translocated to the nuclear envelope through two distinct modes of nuclear import.

Schmeiser C, Borst E, Sticht H, Marschall M, Milbradt J.

J Gen Virol. 2013 Sep;94(Pt 9):2056-69. doi: 10.1099/vir.0.052571-0. Epub 2013 Jun 5.


Specific residues of a conserved domain in the N terminus of the human cytomegalovirus pUL50 protein determine its intranuclear interaction with pUL53.

Milbradt J, Auerochs S, Sevvana M, Muller YA, Sticht H, Marschall M.

J Biol Chem. 2012 Jul 6;287(28):24004-16. doi: 10.1074/jbc.M111.331207. Epub 2012 May 15.

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