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Items: 1 to 20 of 28


Bumetanide-Derived Aquaporin 1 Inhibitors, AqB013 and AqB050 Inhibit Tube Formation of Endothelial Cells through Induction of Apoptosis and Impaired Migration In Vitro.

Tomita Y, Palethorpe HM, Smith E, Nakhjavani M, Townsend AR, Price TJ, Yool AJ, Hardingham JE.

Int J Mol Sci. 2019 Apr 12;20(8). pii: E1818. doi: 10.3390/ijms20081818.


Reduced aquaporin-1 transcript expression in colorectal carcinoma is associated with promoter hypermethylation.

Smith E, Tomita Y, Palethorpe HM, Howell S, Nakhjavani M, Townsend AR, Price TJ, Young JP, Hardingham JE.

Epigenetics. 2019 Feb;14(2):158-170. doi: 10.1080/15592294.2019.1580112. Epub 2019 Feb 20.


Ginsenoside Rg3: Potential Molecular Targets and Therapeutic Indication in Metastatic Breast Cancer.

Nakhjavani M, Hardingham JE, Palethorpe HM, Tomita Y, Smith E, Price TJ, Townsend AR.

Medicines (Basel). 2019 Jan 23;6(1). pii: E17. doi: 10.3390/medicines6010017. Review.


Outcomes for Metastatic Colorectal Cancer Based on Microsatellite Instability: Results from the South Australian Metastatic Colorectal Cancer Registry.

Chong LC, Townsend AR, Young J, Roy A, Piantadosi C, Hardingham JE, Roder D, Karapetis C, Padbury R, Maddern G, Moore J, Price TJ.

Target Oncol. 2019 Feb;14(1):85-91. doi: 10.1007/s11523-018-0615-9.


The Purified Extract from the Medicinal Plant Bacopa monnieri, Bacopaside II, Inhibits Growth of Colon Cancer Cells In Vitro by Inducing Cell Cycle Arrest and Apoptosis.

Smith E, Palethorpe HM, Tomita Y, Pei JV, Townsend AR, Price TJ, Young JP, Yool AJ, Hardingham JE.

Cells. 2018 Jul 21;7(7). pii: E81. doi: 10.3390/cells7070081.


The Aquaporin 1 Inhibitor Bacopaside II Reduces Endothelial Cell Migration and Tubulogenesis and Induces Apoptosis.

Palethorpe HM, Tomita Y, Smith E, Pei JV, Townsend AR, Price TJ, Young JP, Yool AJ, Hardingham JE.

Int J Mol Sci. 2018 Feb 26;19(3). pii: E653. doi: 10.3390/ijms19030653.


Findings in young adults at colonoscopy from a hospital service database audit.

Wong S, Lidums I, Rosty C, Ruszkiewicz A, Parry S, Win AK, Tomita Y, Vatandoust S, Townsend A, Patel D, Hardingham JE, Roder D, Smith E, Drew P, Marker J, Uylaki W, Hewett P, Worthley DL, Symonds E, Young GP, Price TJ, Young JP.

BMC Gastroenterol. 2017 Apr 19;17(1):56. doi: 10.1186/s12876-017-0612-y.


Soluble HLA-G is a differential prognostic marker in sequential colorectal cancer disease stages.

Kirana C, Ruszkiewicz A, Stubbs RS, Hardingham JE, Hewett PJ, Maddern GJ, Hauben E.

Int J Cancer. 2017 Jun 1;140(11):2577-2586. doi: 10.1002/ijc.30667. Epub 2017 Mar 24.


Role of Aquaporin 1 Signalling in Cancer Development and Progression.

Tomita Y, Dorward H, Yool AJ, Smith E, Townsend AR, Price TJ, Hardingham JE.

Int J Mol Sci. 2017 Jan 29;18(2). pii: E299. doi: 10.3390/ijms18020299. Review.


Biology and therapeutic implications of VEGF-A splice isoforms and single-nucleotide polymorphisms in colorectal cancer.

Canavese M, Ngo DT, Maddern GJ, Hardingham JE, Price TJ, Hauben E.

Int J Cancer. 2017 May 15;140(10):2183-2191. doi: 10.1002/ijc.30567. Epub 2017 Feb 2. Review.


Differential Inhibition of Water and Ion Channel Activities of Mammalian Aquaporin-1 by Two Structurally Related Bacopaside Compounds Derived from the Medicinal Plant Bacopa monnieri.

Pei JV, Kourghi M, De Ieso ML, Campbell EM, Dorward HS, Hardingham JE, Yool AJ.

Mol Pharmacol. 2016 Oct;90(4):496-507. doi: 10.1124/mol.116.105882. Epub 2016 Jul 29.


Pharmacological blockade of aquaporin-1 water channel by AqB013 restricts migration and invasiveness of colon cancer cells and prevents endothelial tube formation in vitro.

Dorward HS, Du A, Bruhn MA, Wrin J, Pei JV, Evdokiou A, Price TJ, Yool AJ, Hardingham JE.

J Exp Clin Cancer Res. 2016 Feb 24;35:36. doi: 10.1186/s13046-016-0310-6.


Detection and Clinical Significance of Circulating Tumor Cells in Colorectal Cancer--20 Years of Progress.

Hardingham JE, Grover P, Winter M, Hewett PJ, Price TJ, Thierry B.

Mol Med. 2015 Oct 27;21 Suppl 1:S25-31. doi: 10.2119/molmed.2015.00149. Review.


Nanostructured polystyrene well plates allow unbiased high-throughput characterization of circulating tumor cells.

Wan Y, Winter M, Delalat B, Hardingham JE, Grover PK, Wrin J, Voelcker NH, Price TJ, Thierry B.

ACS Appl Mater Interfaces. 2014 Dec 10;6(23):20828-36. doi: 10.1021/am505201s. Epub 2014 Nov 18.


Rising incidence of early-onset colorectal cancer in Australia over two decades: report and review.

Young JP, Win AK, Rosty C, Flight I, Roder D, Young GP, Frank O, Suthers GK, Hewett PJ, Ruszkiewicz A, Hauben E, Adelstein BA, Parry S, Townsend A, Hardingham JE, Price TJ.

J Gastroenterol Hepatol. 2015 Jan;30(1):6-13. doi: 10.1111/jgh.12792. Review.


Can we accurately report PTEN status in advanced colorectal cancer?

Hocking C, Hardingham JE, Broadbridge V, Wrin J, Townsend AR, Tebbutt N, Cooper J, Ruszkiewicz A, Lee C, Price TJ.

BMC Cancer. 2014 Feb 25;14:128. doi: 10.1186/1471-2407-14-128.


KRAS G13D Mutation and Sensitivity to Cetuximab or Panitumumab in a Colorectal Cancer Cell Line Model.

Kumar SS, Price TJ, Mohyieldin O, Borg M, Townsend A, Hardingham JE.

Gastrointest Cancer Res. 2014 Jan;7(1):23-6.


Proangiogenic tumor proteins as potential predictive or prognostic biomarkers for bevacizumab therapy in metastatic colorectal cancer.

Bruhn MA, Townsend AR, Khoon Lee C, Shivasami A, Price TJ, Wrin J, Arentz G, Tebbutt NC, Hocking C, Cunningham D, Hardingham JE; BHI in collaboration with AGITG.

Int J Cancer. 2014 Aug 1;135(3):731-41. doi: 10.1002/ijc.28698. Epub 2014 Jan 24.


Prognostic impact and the relevance of PTEN copy number alterations in patients with advanced colorectal cancer (CRC) receiving bevacizumab.

Price TJ, Hardingham JE, Lee CK, Townsend AR, Wrin JW, Wilson K, Weickhardt A, Simes RJ, Murone C, Tebbutt NC.

Cancer Med. 2013 Jun;2(3):277-85. doi: 10.1002/cam4.75. Epub 2013 Mar 25.


A simple, cost-effective and flexible method for processing of snap-frozen tissue to prepare large amounts of intact RNA using laser microdissection.

Grover PK, Cummins AG, Price TJ, Roberts-Thomson IC, Hardingham JE.

Biochimie. 2012 Dec;94(12):2491-7. doi: 10.1016/j.biochi.2012.06.031. Epub 2012 Jul 10.


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