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ZEB1/NuRD complex suppresses TBC1D2b to stimulate E-cadherin internalization and promote metastasis in lung cancer.

Manshouri R, Coyaud E, Kundu ST, Peng DH, Stratton SA, Alton K, Bajaj R, Fradette JJ, Minelli R, Peoples MD, Carugo A, Chen F, Bristow C, Kovacs JJ, Barton MC, Heffernan T, Creighton CJ, Raught B, Gibbons DL.

Nat Commun. 2019 Nov 12;10(1):5125. doi: 10.1038/s41467-019-12832-z.


Ntrk1 Promotes Resistance to PD-1 Checkpoint Blockade in Mesenchymal Kras/p53 Mutant Lung Cancer.

Konen JM, Rodriguez BL, Fradette JJ, Gibson L, Davis D, Minelli R, Peoples MD, Kovacs J, Carugo A, Bristow C, Heffernan T, Gibbons DL.

Cancers (Basel). 2019 Apr 2;11(4). pii: E462. doi: 10.3390/cancers11040462.


Vascular Endothelial Growth Factor Receptor 3 Regulates Endothelial Function Through β-Arrestin 1.

Ma Z, Yu YR, Badea CT, Kovacs JJ, Xiong X, Comhair S, Piantadosi CA, Rajagopal S.

Circulation. 2019 Mar 26;139(13):1629-1642. doi: 10.1161/CIRCULATIONAHA.118.034961.


PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy.

Hsu JI, Dayaram T, Tovy A, De Braekeleer E, Jeong M, Wang F, Zhang J, Heffernan TP, Gera S, Kovacs JJ, Marszalek JR, Bristow C, Yan Y, Garcia-Manero G, Kantarjian H, Vassiliou G, Futreal PA, Donehower LA, Takahashi K, Goodell MA.

Cell Stem Cell. 2018 Nov 1;23(5):700-713.e6. doi: 10.1016/j.stem.2018.10.004.


Targeted disruption of β-arrestin 2-mediated signaling pathways by aptamer chimeras leads to inhibition of leukemic cell growth.

Kotula JW, Sun J, Li M, Pratico ED, Fereshteh MP, Ahrens DP, Sullenger BA, Kovacs JJ.

PLoS One. 2014 Apr 15;9(4):e93441. doi: 10.1371/journal.pone.0093441. eCollection 2014.


β-Arrestin regulation of myosin light chain phosphorylation promotes AT1aR-mediated cell contraction and migration.

Simard E, Kovacs JJ, Miller WE, Kim J, Grandbois M, Lefkowitz RJ.

PLoS One. 2013 Nov 8;8(11):e80532. doi: 10.1371/journal.pone.0080532. eCollection 2013.


β-Arrestin2 mediates the initiation and progression of myeloid leukemia.

Fereshteh M, Ito T, Kovacs JJ, Zhao C, Kwon HY, Tornini V, Konuma T, Chen M, Lefkowitz RJ, Reya T.

Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12532-7. doi: 10.1073/pnas.1209815109. Epub 2012 Jul 5.


A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1.

Hara MR, Kovacs JJ, Whalen EJ, Rajagopal S, Strachan RT, Grant W, Towers AJ, Williams B, Lam CM, Xiao K, Shenoy SK, Gregory SG, Ahn S, Duckett DR, Lefkowitz RJ.

Nature. 2011 Aug 21;477(7364):349-53. doi: 10.1038/nature10368.


β-arrestin deficiency protects against pulmonary fibrosis in mice and prevents fibroblast invasion of extracellular matrix.

Lovgren AK, Kovacs JJ, Xie T, Potts EN, Li Y, Foster WM, Liang J, Meltzer EB, Jiang D, Lefkowitz RJ, Noble PW.

Sci Transl Med. 2011 Mar 16;3(74):74ra23. doi: 10.1126/scitranslmed.3001564.


Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR).

Xiao K, Sun J, Kim J, Rajagopal S, Zhai B, Villén J, Haas W, Kovacs JJ, Shukla AK, Hara MR, Hernandez M, Lachmann A, Zhao S, Lin Y, Cheng Y, Mizuno K, Ma'ayan A, Gygi SP, Lefkowitz RJ.

Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15299-304. doi: 10.1073/pnas.1008461107. Epub 2010 Aug 4. Erratum in: Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13464.


Arrestin development: emerging roles for beta-arrestins in developmental signaling pathways.

Kovacs JJ, Hara MR, Davenport CL, Kim J, Lefkowitz RJ.

Dev Cell. 2009 Oct;17(4):443-58. doi: 10.1016/j.devcel.2009.09.011. Review.


Characterization of nickel-decorated PLGA particles anchored with a his-tagged polycation.

Kovacs JR, Tidball J, Ross A, Jia L, Zheng Y, Gawalt ES, Meng WS.

J Biomater Sci Polym Ed. 2009;20(9):1307-20. doi: 10.1163/156856209X453015.


beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice.

Walters RW, Shukla AK, Kovacs JJ, Violin JD, DeWire SM, Lam CM, Chen JR, Muehlbauer MJ, Whalen EJ, Lefkowitz RJ.

J Clin Invest. 2009 May;119(5):1312-21. doi: 10.1172/JCI36806. Epub 2009 Apr 6.


Beta-arrestin-mediated localization of smoothened to the primary cilium.

Kovacs JJ, Whalen EJ, Liu R, Xiao K, Kim J, Chen M, Wang J, Chen W, Lefkowitz RJ.

Science. 2008 Jun 27;320(5884):1777-81. doi: 10.1126/science.1157983. Epub 2008 May 22.


Expansion of Foxp3-expressing regulatory T cells in vitro by dendritic cells modified with polymeric particles carrying a plasmid encoding interleukin-10.

Jia L, Kovacs JR, Zheng Y, Shen H, Gawalt ES, Meng WS.

Biomaterials. 2008 Mar;29(9):1250-61. Epub 2007 Dec 20.


Solution structure of the Ubp-M BUZ domain, a highly specific protein module that recognizes the C-terminal tail of free ubiquitin.

Pai MT, Tzeng SR, Kovacs JJ, Keaton MA, Li SS, Yao TP, Zhou P.

J Mol Biol. 2007 Jul 6;370(2):290-302. Epub 2007 Apr 12.


Chaperoning steroid hormone signaling via reversible acetylation.

Kovacs JJ, Cohen TJ, Yao TP.

Nucl Recept Signal. 2005;3:e004. Epub 2005 Oct 21.


Secondary anchor substitutions in an HLA-A*0201-restricted T-cell epitope derived from Her-2/neu.

Joseph MA, Mitchell ML, Evanseck JD, Kovacs JR, Jia L, Shen H, Meng WS.

Mol Immunol. 2007 Jan;44(4):322-31. Epub 2006 Apr 4.


Attenuated alloreactivity of dendritic cells engineered with surface-modified microspheres carrying a plasmid encoding interleukin-10.

Jia L, Kovacs JR, Zheng Y, Gawalt ES, Shen H, Meng WS.

Biomaterials. 2006 Mar;27(9):2076-82. Epub 2005 Oct 10. Erratum in: Biomaterials. 2006 Jul;27(21):4058.


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