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Items: 8


Targeting the Hippo Pathway and Cancer through the TEAD Family of Transcription Factors.

Holden JK, Cunningham CN.

Cancers (Basel). 2018 Mar 20;10(3). pii: E81. doi: 10.3390/cancers10030081. Review.


Targeting Bacterial Nitric Oxide Synthase with Aminoquinoline-Based Inhibitors.

Holden JK, Lewis MC, Cinelli MA, Abdullatif Z, Pensa AV, Silverman RB, Poulos TL.

Biochemistry. 2016 Oct 4;55(39):5587-5594. Epub 2016 Sep 21.


Elucidating nitric oxide synthase domain interactions by molecular dynamics.

Hollingsworth SA, Holden JK, Li H, Poulos TL.

Protein Sci. 2016 Feb;25(2):374-82. doi: 10.1002/pro.2824. Epub 2015 Oct 22.


Nitric Oxide Synthase as a Target for Methicillin-Resistant Staphylococcus aureus.

Holden JK, Kang S, Beasley FC, Cinelli MA, Li H, Roy SG, Dejam D, Edinger AL, Nizet V, Silverman RB, Poulos TL.

Chem Biol. 2015 Jun 18;22(6):785-92. doi: 10.1016/j.chembiol.2015.05.013.


Inhibitor Bound Crystal Structures of Bacterial Nitric Oxide Synthase.

Holden JK, Dejam D, Lewis MC, Huang H, Kang S, Jing Q, Xue F, Silverman RB, Poulos TL.

Biochemistry. 2015 Jul 7;54(26):4075-82. doi: 10.1021/acs.biochem.5b00431. Epub 2015 Jun 23.


Structure-based design of bacterial nitric oxide synthase inhibitors.

Holden JK, Kang S, Hollingsworth SA, Li H, Lim N, Chen S, Huang H, Xue F, Tang W, Silverman RB, Poulos TL.

J Med Chem. 2015 Jan 22;58(2):994-1004. doi: 10.1021/jm501723p. Epub 2015 Jan 6.


Identification of redox partners and development of a novel chimeric bacterial nitric oxide synthase for structure activity analyses.

Holden JK, Lim N, Poulos TL.

J Biol Chem. 2014 Oct 17;289(42):29437-45. doi: 10.1074/jbc.M114.595165. Epub 2014 Sep 6.


Structural and biological studies on bacterial nitric oxide synthase inhibitors.

Holden JK, Li H, Jing Q, Kang S, Richo J, Silverman RB, Poulos TL.

Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18127-31. doi: 10.1073/pnas.1314080110. Epub 2013 Oct 21.

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