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Items: 1 to 20 of 45

1.

Synthesis and evaluation of 1,3,5-triazine derivatives as sunscreens useful to prevent skin cancer.

Reis JS, Corrêa MA, Ribeiro CA, Dos Santos JL.

Bioorg Med Chem Lett. 2019 Dec 15;29(24):126755. doi: 10.1016/j.bmcl.2019.126755. Epub 2019 Oct 28.

PMID:
31732408
2.

Boron in drug design: Recent advances in the development of new therapeutic agents.

Fernandes GFS, Denny WA, Dos Santos JL.

Eur J Med Chem. 2019 Oct 1;179:791-804. doi: 10.1016/j.ejmech.2019.06.092. Epub 2019 Jul 3. Review.

PMID:
31288128
3.

The use of Sulfonamide Derivatives in the Treatment of Trypanosomatid Parasites, Including Trypanosoma cruzi, Trypanosoma brucei, and Leishmania ssp.

Scarim CB, Chelucci RC, Dos Santos JL, Chin CM.

Med Chem. 2019 Jun 20. doi: 10.2174/1573406415666190620141109. [Epub ahead of print]

PMID:
31218962
4.

A critical review of HPLC-based analytical methods for quantification of Linezolid.

Fernandes GFDS, Salgado HRN, Santos JLD.

Crit Rev Anal Chem. 2019 Apr 24:1-16. doi: 10.1080/10408347.2019.1605876. [Epub ahead of print]

PMID:
31017000
5.

Recent advances in the discovery of small molecules targeting glioblastoma.

Fernandes GFDS, Fernandes BC, Valente V, Dos Santos JL.

Eur J Med Chem. 2019 Feb 15;164:8-26. doi: 10.1016/j.ejmech.2018.12.033. Epub 2018 Dec 16. Review.

PMID:
30583248
6.

Thiazole, thio and semicarbazone derivatives against tropical infective diseases: Chagas disease, human African trypanosomiasis (HAT), leishmaniasis, and malaria.

Scarim CB, Jornada DH, Machado MGM, Ferreira CMR, Dos Santos JL, Chung MC.

Eur J Med Chem. 2019 Jan 15;162:378-395. doi: 10.1016/j.ejmech.2018.11.013. Epub 2018 Nov 12. Review.

PMID:
30453246
7.

Current advances in drug discovery for Chagas disease.

Scarim CB, Jornada DH, Chelucci RC, de Almeida L, Dos Santos JL, Chung MC.

Eur J Med Chem. 2018 Jul 15;155:824-838. doi: 10.1016/j.ejmech.2018.06.040. Epub 2018 Jun 20. Review.

PMID:
30033393
8.

Discovery of phenylsulfonylfuroxan derivatives as gamma globin inducers by histone acetylation.

Melo TRF, Kumkhaek C, Fernandes GFDS, Lopes Pires ME, Chelucci RC, Barbieri KP, Coelho F, Capote TSO, Lanaro C, Carlos IZ, Marcondes S, Chegaev K, Guglielmo S, Fruttero R, Chung MC, Costa FF, Rodgers GP, Dos Santos JL.

Eur J Med Chem. 2018 Jun 25;154:341-353. doi: 10.1016/j.ejmech.2018.05.008. Epub 2018 May 30.

PMID:
29852459
9.

Heterocyclic N-oxides - A Promising Class of Agents against Tuberculosis, Malaria and Neglected Tropical Diseases.

Dos Santos Fernandes GF, Pavan AR, Dos Santos JL.

Curr Pharm Des. 2018;24(12):1325-1340. doi: 10.2174/1381612824666180417122625. Review.

PMID:
29663875
10.

A thalidomide-hydroxyurea hybrid increases HbF production in sickle cell mice and reduces the release of proinflammatory cytokines in cultured monocytes.

Lanaro C, Franco-Penteado CF, Silva FH, Fertrin KY, Dos Santos JL, Wade M, Yerigenahally S, de Melo TR, Chin CM, Kutlar A, Meiler SE, Costa FF.

Exp Hematol. 2018 Feb;58:35-38. doi: 10.1016/j.exphem.2017.10.003. Epub 2017 Nov 3.

PMID:
29108926
11.

Epigenetic Regulatory Mechanisms Induced by Resveratrol.

Fernandes GFS, Silva GDB, Pavan AR, Chiba DE, Chin CM, Dos Santos JL.

Nutrients. 2017 Nov 1;9(11). pii: E1201. doi: 10.3390/nu9111201. Review.

12.

Dietary Compound Resveratrol Is a Pan-BET Bromodomain Inhibitor.

Dutra LA, Heidenreich D, Silva GDBD, Man Chin C, Knapp S, Santos JLD.

Nutrients. 2017 Oct 27;9(11). pii: E1172. doi: 10.3390/nu9111172.

13.

Design, Synthesis, and Characterization of N-Oxide-Containing Heterocycles with in Vivo Sterilizing Antitubercular Activity.

Dos Santos Fernandes GF, de Souza PC, Moreno-Viguri E, Santivañez-Veliz M, Paucar R, Pérez-Silanes S, Chegaev K, Guglielmo S, Lazzarato L, Fruttero R, Man Chin C, da Silva PB, Chorilli M, Solcia MC, Ribeiro CM, Silva CSP, Marino LB, Bosquesi PL, Hunt DM, de Carvalho LPS, de Souza Costa CA, Cho SH, Wang Y, Franzblau SG, Pavan FR, Dos Santos JL.

J Med Chem. 2017 Oct 26;60(20):8647-8660. doi: 10.1021/acs.jmedchem.7b01332. Epub 2017 Oct 16.

14.

In vivo antileishmanial activity and histopathological evaluation in Leishmania infantum infected hamsters after treatment with a furoxan derivative.

de Almeida L, Passalacqua TG, Dutra LA, Fonseca JNVD, Nascimento RFQ, Imamura KB, de Andrade CR, Dos Santos JL, Graminha MAS.

Biomed Pharmacother. 2017 Nov;95:536-547. doi: 10.1016/j.biopha.2017.08.096. Epub 2017 Sep 12.

PMID:
28866421
15.

Advances in Drug Discovery of New Antitubercular Multidrug-Resistant Compounds.

Fernandes GFDS, Man Chin C, Dos Santos JL.

Pharmaceuticals (Basel). 2017 Jun 1;10(2). pii: E51. doi: 10.3390/ph10020051. Review.

16.

Synthesis, antiplatelet and antithrombotic activities of resveratrol derivatives with NO-donor properties.

Dutra LA, Guanaes JFO, Johmann N, Lopes Pires ME, Chin CM, Marcondes S, Dos Santos JL.

Bioorg Med Chem Lett. 2017 Jun 1;27(11):2450-2453. doi: 10.1016/j.bmcl.2017.04.007. Epub 2017 Apr 4.

PMID:
28400236
17.

Isoniazid: A Review of Characteristics, Properties and Analytical Methods.

Fernandes GFDS, Salgado HRN, Santos JLD.

Crit Rev Anal Chem. 2017 Jul 4;47(4):298-308. doi: 10.1080/10408347.2017.1281098. Epub 2017 Jan 12. Review.

PMID:
28080136
18.

Unraveling the Anticancer Effect of Curcumin and Resveratrol.

Pavan AR, Silva GD, Jornada DH, Chiba DE, Fernandes GF, Man Chin C, Dos Santos JL.

Nutrients. 2016 Nov 10;8(11). pii: E628. Review.

19.

Synthesis and biological activity of furoxan derivatives against Mycobacterium tuberculosis.

Fernandes GFDS, de Souza PC, Marino LB, Chegaev K, Guglielmo S, Lazzarato L, Fruttero R, Chung MC, Pavan FR, Dos Santos JL.

Eur J Med Chem. 2016 Nov 10;123:523-531. doi: 10.1016/j.ejmech.2016.07.039. Epub 2016 Jul 21.

PMID:
27508879
20.

The Prodrug Approach: A Successful Tool for Improving Drug Solubility.

Jornada DH, dos Santos Fernandes GF, Chiba DE, de Melo TR, dos Santos JL, Chung MC.

Molecules. 2015 Dec 29;21(1):42. doi: 10.3390/molecules21010042. Review.

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