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Items: 1 to 20 of 25

1.

Fisetin, a 3,7,3',4'-Tetrahydroxyflavone Inhibits the PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin Models.

Chamcheu JC, Esnault S, Adhami VM, Noll AL, Banang-Mbeumi S, Roy T, Singh SS, Huang S, Kousoulas KG, Mukhtar H.

Cells. 2019 Sep 15;8(9). pii: E1089. doi: 10.3390/cells8091089.

2.

Role and Therapeutic Targeting of the PI3K/Akt/mTOR Signaling Pathway in Skin Cancer: A Review of Current Status and Future Trends on Natural and Synthetic Agents Therapy.

Chamcheu JC, Roy T, Uddin MB, Banang-Mbeumi S, Chamcheu RN, Walker AL, Liu YY, Huang S.

Cells. 2019 Jul 31;8(8). pii: E803. doi: 10.3390/cells8080803. Review.

3.

Anticancer Properties of Graviola (Annona muricata): A Comprehensive Mechanistic Review.

Rady I, Bloch MB, Chamcheu RN, Banang Mbeumi S, Anwar MR, Mohamed H, Babatunde AS, Kuiate JR, Noubissi FK, El Sayed KA, Whitfield GK, Chamcheu JC.

Oxid Med Cell Longev. 2018 Jul 30;2018:1826170. doi: 10.1155/2018/1826170. eCollection 2018. Review.

4.

Chitosan-based nanoformulated (-)-epigallocatechin-3-gallate (EGCG) modulates human keratinocyte-induced responses and alleviates imiquimod-induced murine psoriasiform dermatitis.

Chamcheu JC, Siddiqui IA, Adhami VM, Esnault S, Bharali DJ, Babatunde AS, Adame S, Massey RJ, Wood GS, Longley BJ, Mousa SA, Mukhtar H.

Int J Nanomedicine. 2018 Jul 20;13:4189-4206. doi: 10.2147/IJN.S165966. eCollection 2018.

5.

Graviola (Annona muricata) Exerts Anti-Proliferative, Anti-Clonogenic and Pro-Apoptotic Effects in Human Non-Melanoma Skin Cancer UW-BCC1 and A431 Cells In Vitro: Involvement of Hedgehog Signaling.

Chamcheu JC, Rady I, Chamcheu RN, Siddique AB, Bloch MB, Banang Mbeumi S, Babatunde AS, Uddin MB, Noubissi FK, Jurutka PW, Liu YY, Spiegelman VS, Whitfield GK, El Sayed KA.

Int J Mol Sci. 2018 Jun 16;19(6). pii: E1791. doi: 10.3390/ijms19061791.

6.

Bioactive Dietary VDR Ligands Regulate Genes Encoding Biomarkers of Skin Repair That Are Associated with Risk for Psoriasis.

Karrys A, Rady I, Chamcheu RN, Sabir MS, Mallick S, Chamcheu JC, Jurutka PW, Haussler MR, Whitfield GK.

Nutrients. 2018 Feb 4;10(2). pii: E174. doi: 10.3390/nu10020174.

7.

Targeted nanoparticles encapsulating (-)-epigallocatechin-3-gallate for prostate cancer prevention and therapy.

Sanna V, Singh CK, Jashari R, Adhami VM, Chamcheu JC, Rady I, Sechi M, Mukhtar H, Siddiqui IA.

Sci Rep. 2017 Feb 1;7:41573. doi: 10.1038/srep41573.

8.

Dual Inhibition of PI3K/Akt and mTOR by the Dietary Antioxidant, Delphinidin, Ameliorates Psoriatic Features In Vitro and in an Imiquimod-Induced Psoriasis-Like Disease in Mice.

Chamcheu JC, Adhami VM, Esnault S, Sechi M, Siddiqui IA, Satyshur KA, Syed DN, Dodwad SM, Chaves-Rodriquez MI, Longley BJ, Wood GS, Mukhtar H.

Antioxid Redox Signal. 2017 Jan 10;26(2):49-69. doi: 10.1089/ars.2016.6769. Epub 2016 Oct 4.

9.

Upregulation of PI3K/AKT/mTOR, FABP5 and PPAR╬▓/╬┤ in Human Psoriasis and Imiquimod-induced Murine Psoriasiform Dermatitis Model.

Chamcheu JC, Chaves-Rodriquez MI, Adhami VM, Siddiqui IA, Wood GS, Longley BJ, Mukhtar H.

Acta Derm Venereol. 2016 Aug 23;96(6):854-6. doi: 10.2340/00015555-2359. No abstract available.

10.

Nanoencapsulation of natural triterpenoid celastrol for prostate cancer treatment.

Sanna V, Chamcheu JC, Pala N, Mukhtar H, Sechi M, Siddiqui IA.

Int J Nanomedicine. 2015 Oct 30;10:6835-46. doi: 10.2147/IJN.S93752. eCollection 2015.

11.

Chemical chaperone therapy, a new strategy for genetic skin fragility disorders.

Chamcheu JC, Siddiqui IA, Mukhtar H.

Exp Dermatol. 2016 Mar;25(3):183-4. doi: 10.1111/exd.12893. No abstract available.

12.

Prodifferentiation, anti-inflammatory and antiproliferative effects of delphinidin, a dietary anthocyanidin, in a full-thickness three-dimensional reconstituted human skin model of psoriasis.

Chamcheu JC, Pal HC, Siddiqui IA, Adhami VM, Ayehunie S, Boylan BT, Noubissi FK, Khan N, Syed DN, Elmets CA, Wood GS, Afaq F, Mukhtar H.

Skin Pharmacol Physiol. 2015;28(4):177-88. doi: 10.1159/000368445. Epub 2015 Jan 22.

13.

Biotransformed soybean extract (BSE) inhibits melanoma cell growth and viability in vitro: involvement of nuclear factor-kappa B signaling.

Vilela FM, Syed DN, Chamcheu JC, Calvo-Castro LA, Fortes VS, Fonseca MJ, Mukhtar H.

PLoS One. 2014 Jul 29;9(7):e103248. doi: 10.1371/journal.pone.0103248. eCollection 2014.

14.

Involvement of ER stress and activation of apoptotic pathways in fisetin induced cytotoxicity in human melanoma.

Syed DN, Lall RK, Chamcheu JC, Haidar O, Mukhtar H.

Arch Biochem Biophys. 2014 Dec 1;563:108-117. doi: 10.1016/j.abb.2014.06.034. Epub 2014 Jul 9.

15.

Excellent anti-proliferative and pro-apoptotic effects of (-)-epigallocatechin-3-gallate encapsulated in chitosan nanoparticles on human melanoma cell growth both in vitro and in vivo.

Siddiqui IA, Bharali DJ, Nihal M, Adhami VM, Khan N, Chamcheu JC, Khan MI, Shabana S, Mousa SA, Mukhtar H.

Nanomedicine. 2014 Nov;10(8):1619-26. doi: 10.1016/j.nano.2014.05.007. Epub 2014 Jun 3.

PMID:
24965756
16.

Fisetin inhibits human melanoma cell growth through direct binding to p70S6K and mTOR: findings from 3-D melanoma skin equivalents and computational modeling.

Syed DN, Chamcheu JC, Khan MI, Sechi M, Lall RK, Adhami VM, Mukhtar H.

Biochem Pharmacol. 2014 Jun 1;89(3):349-60. doi: 10.1016/j.bcp.2014.03.007. Epub 2014 Mar 24.

17.

Delphinidin, a dietary antioxidant, induces human epidermal keratinocyte differentiation but not apoptosis: studies in submerged and three-dimensional epidermal equivalent models.

Chamcheu JC, Afaq F, Syed DN, Siddiqui IA, Adhami VM, Khan N, Singh S, Boylan BT, Wood GS, Mukhtar H.

Exp Dermatol. 2013 May;22(5):342-8. doi: 10.1111/exd.12140.

18.

Pomegranate extracts and cancer prevention: molecular and cellular activities.

Syed DN, Chamcheu JC, Adhami VM, Mukhtar H.

Anticancer Agents Med Chem. 2013 Oct;13(8):1149-61. Review.

19.

Progress towards genetic and pharmacological therapies for keratin genodermatoses: current perspective and future promise.

Chamcheu JC, Wood GS, Siddiqui IA, Syed DN, Adhami VM, Teng JM, Mukhtar H.

Exp Dermatol. 2012 Jul;21(7):481-9. doi: 10.1111/j.1600-0625.2012.01534.x. Review.

20.

Impact of nanotechnology in cancer: emphasis on nanochemoprevention.

Siddiqui IA, Adhami VM, Chamcheu JC, Mukhtar H.

Int J Nanomedicine. 2012;7:591-605. doi: 10.2147/IJN.S26026. Epub 2012 Feb 2. Review.

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