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Items: 1 to 20 of 44


Mouse Norovirus Infection Arrests Host Cell Translation Uncoupled from the Stress Granule-PKR-eIF2α Axis.

Fritzlar S, Aktepe TE, Chao YW, Kenney ND, McAllaster MR, Wilen CB, White PA, Mackenzie JM.

MBio. 2019 Jun 18;10(3). pii: e00960-19. doi: 10.1128/mBio.00960-19.


Downregulation of MHC Class I Expression by Influenza A and B Viruses.

Koutsakos M, McWilliam HEG, Aktepe TE, Fritzlar S, Illing PT, Mifsud NA, Purcell AW, Rockman S, Reading PC, Vivian JP, Rossjohn J, Brooks AG, Mackenzie JM, Mintern JD, Villadangos JA, Nguyen THO, Kedzierska K.

Front Immunol. 2019 May 29;10:1158. doi: 10.3389/fimmu.2019.01158. eCollection 2019.


The Adenosine Analogue NITD008 has Potent Antiviral Activity against Human and Animal Caliciviruses.

Enosi Tuipulotu D, Fumian TM, Netzler NE, Mackenzie JM, White PA.

Viruses. 2019 May 30;11(6). pii: E496. doi: 10.3390/v11060496.


Nlrp3 inflammasome activation and Gasdermin D-driven pyroptosis are immunopathogenic upon gastrointestinal norovirus infection.

Dubois H, Sorgeloos F, Sarvestani ST, Martens L, Saeys Y, Mackenzie JM, Lamkanfi M, van Loo G, Goodfellow I, Wullaert A.

PLoS Pathog. 2019 Apr 24;15(4):e1007709. doi: 10.1371/journal.ppat.1007709. eCollection 2019 Apr.


Determinants of Zika virus host tropism uncovered by deep mutational scanning.

Setoh YX, Amarilla AA, Peng NYG, Griffiths RE, Carrera J, Freney ME, Nakayama E, Ogawa S, Watterson D, Modhiran N, Nanyonga FE, Torres FJ, Slonchak A, Periasamy P, Prow NA, Tang B, Harrison J, Hobson-Peters J, Cuddihy T, Cooper-White J, Hall RA, Young PR, Mackenzie JM, Wolvetang E, Bloom JD, Suhrbier A, Khromykh AA.

Nat Microbiol. 2019 May;4(5):876-887. doi: 10.1038/s41564-019-0399-4. Epub 2019 Mar 18.


Antiviral Candidates for Treating Hepatitis E Virus Infection.

Netzler NE, Enosi Tuipulotu D, Vasudevan SG, Mackenzie JM, White PA.

Antimicrob Agents Chemother. 2019 May 24;63(6). pii: e00003-19. doi: 10.1128/AAC.00003-19. Print 2019 Jun.


The Microtubule-Associated Innate Immune Sensor GEF-H1 Does Not Influence Mouse Norovirus Replication in Murine Macrophages.

Fritzlar S, White PA, Mackenzie JM.

Viruses. 2019 Jan 10;11(1). pii: E47. doi: 10.3390/v11010047.


Mouse Norovirus Infection Reduces the Surface Expression of Major Histocompatibility Complex Class I Proteins and Inhibits CD8+ T Cell Recognition and Activation.

Fritzlar S, Jegaskanda S, Aktepe TE, Prier JE, Holz LE, White PA, Mackenzie JM.

J Virol. 2018 Aug 29;92(18). pii: e00286-18. doi: 10.1128/JVI.00286-18. Print 2018 Sep 15.


Shaping the flavivirus replication complex: It is curvaceous!

Aktepe TE, Mackenzie JM.

Cell Microbiol. 2018 Aug;20(8):e12884. doi: 10.1111/cmi.12884. Epub 2018 Jun 29. Review.


Phospholipase A2 activity during the replication cycle of the flavivirus West Nile virus.

Liebscher S, Ambrose RL, Aktepe TE, Mikulasova A, Prier JE, Gillespie LK, Lopez-Denman AJ, Rupasinghe TWT, Tull D, McConville MJ, Mackenzie JM.

PLoS Pathog. 2018 Apr 30;14(4):e1007029. doi: 10.1371/journal.ppat.1007029. eCollection 2018 Apr.


Nucleocytoplasmic shuttling of the West Nile virus RNA-dependent RNA polymerase NS5 is critical to infection.

Lopez-Denman AJ, Russo A, Wagstaff KM, White PA, Jans DA, Mackenzie JM.

Cell Microbiol. 2018 Aug;20(8):e12848. doi: 10.1111/cmi.12848. Epub 2018 Apr 24.


TLR7 Agonists Display Potent Antiviral Effects against Norovirus Infection via Innate Stimulation.

Enosi Tuipulotu D, Netzler NE, Lun JH, Mackenzie JM, White PA.

Antimicrob Agents Chemother. 2018 Apr 26;62(5). pii: e02417-17. doi: 10.1128/AAC.02417-17. Print 2018 May.


The Host Protein Reticulon 3.1A Is Utilized by Flaviviruses to Facilitate Membrane Remodelling.

Aktepe TE, Liebscher S, Prier JE, Simmons CP, Mackenzie JM.

Cell Rep. 2017 Nov 7;21(6):1639-1654. doi: 10.1016/j.celrep.2017.10.055.


RNA Sequencing of Murine Norovirus-Infected Cells Reveals Transcriptional Alteration of Genes Important to Viral Recognition and Antigen Presentation.

Enosi Tuipulotu D, Netzler NE, Lun JH, Mackenzie JM, White PA.

Front Immunol. 2017 Aug 11;8:959. doi: 10.3389/fimmu.2017.00959. eCollection 2017.


Broad-spectrum non-nucleoside inhibitors for caliciviruses.

Netzler NE, Enosi Tuipulotu D, Eltahla AA, Lun JH, Ferla S, Brancale A, Urakova N, Frese M, Strive T, Mackenzie JM, White PA.

Antiviral Res. 2017 Oct;146:65-75. doi: 10.1016/j.antiviral.2017.07.014. Epub 2017 Jul 27.


The IMPORTance of the Nucleus during Flavivirus Replication.

Lopez-Denman AJ, Mackenzie JM.

Viruses. 2017 Jan 19;9(1). pii: E14. doi: 10.3390/v9010014. Review.


The Norovirus NS3 Protein Is a Dynamic Lipid- and Microtubule-Associated Protein Involved in Viral RNA Replication.

Cotton BT, Hyde JL, Sarvestani ST, Sosnovtsev SV, Green KY, White PA, Mackenzie JM.

J Virol. 2017 Jan 18;91(3). pii: e02138-16. doi: 10.1128/JVI.02138-16. Print 2017 Feb 1.


Norovirus Infection: Replication, Manipulation of Host, and Interaction with the Host Immune Response.

Sarvestani ST, Cotton B, Fritzlar S, O'Donnell TB, Mackenzie JM.

J Interferon Cytokine Res. 2016 Apr;36(4):215-25. doi: 10.1089/jir.2015.0124. Epub 2016 Jan 27. Review.


Mouse Norovirus infection promotes autophagy induction to facilitate replication but prevents final autophagosome maturation.

O'Donnell TB, Hyde JL, Mintern JD, Mackenzie JM.

Virology. 2016 May;492:130-9. doi: 10.1016/j.virol.2016.02.018. Epub 2016 Mar 21.


Differential utilisation of ceramide during replication of the flaviviruses West Nile and dengue virus.

Aktepe TE, Pham H, Mackenzie JM.

Virology. 2015 Oct;484:241-50. doi: 10.1016/j.virol.2015.06.015. Epub 2015 Jun 26.

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