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Items: 11


Src phosphorylation converts Mdm2 from a ubiquitinating to a neddylating E3 ligase.

Batuello CN, Hauck PM, Gendron JM, Lehman JA, Mayo LD.

Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1749-54. doi: 10.1073/pnas.1416656112. Epub 2015 Jan 26.


Serdemetan antagonizes the Mdm2-HIF1α axis leading to decreased levels of glycolytic enzymes.

Lehman JA, Hauck PM, Gendron JM, Batuello CN, Eitel JA, Albig A, Kadakia MP, Mayo LD.

PLoS One. 2013 Sep 6;8(9):e74741. doi: 10.1371/journal.pone.0074741. eCollection 2013.


Integration of DNA damage and repair with murine double-minute 2 (Mdm2) in tumorigenesis.

Lehman JA, Mayo LD.

Int J Mol Sci. 2012 Dec 3;13(12):16373-86. doi: 10.3390/ijms131216373. Review.


Induction of apoptotic genes by a p73-phosphatase and tensin homolog (p73-PTEN) protein complex in response to genotoxic stress.

Lehman JA, Waning DL, Batuello CN, Cipriano R, Kadakia MP, Mayo LD.

J Biol Chem. 2011 Oct 21;286(42):36631-40. doi: 10.1074/jbc.M110.217620. Epub 2011 Aug 26.


c-Abl phosphorylation of Mdm2 facilitates Mdm2-Mdmx complex formation.

Waning DL, Lehman JA, Batuello CN, Mayo LD.

J Biol Chem. 2011 Jan 7;286(1):216-22. doi: 10.1074/jbc.M110.183012. Epub 2010 Nov 16.


Controlling the Mdm2-Mdmx-p53 Circuit.

Waning DL, Lehman JA, Batuello CN, Mayo LD.

Pharmaceuticals (Basel). 2010 May 18;3(5):1576-1593.


Therapeutic considerations for Mdm2: not just a one trick pony.

Lehman JA, Eitel JA, Batuello CN, Mayo LD.

Expert Opin Drug Discov. 2008 Nov;3(11):1309-1321.


DNA-dependent conformational changes in the Ku heterodimer.

Lehman JA, Hoelz DJ, Turchi JJ.

Biochemistry. 2008 Apr 15;47(15):4359-68. doi: 10.1021/bi702284c. Epub 2008 Mar 21.


Molecular crosstalk between p70S6k and MAPK cell signaling pathways.

Lehman JA, Gomez-Cambronero J.

Biochem Biophys Res Commun. 2002 Apr 26;293(1):463-9.

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