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Items: 1 to 20 of 42


The Radiobiological Effects of Proton Beam Therapy: Impact on DNA Damage and Repair.

Vitti ET, Parsons JL.

Cancers (Basel). 2019 Jul 5;11(7). pii: E946. doi: 10.3390/cancers11070946. Review.


The Biochemical Role of the Human NEIL1 and NEIL3 DNA Glycosylases on Model DNA Replication Forks.

Albelazi MS, Martin PR, Mohammed S, Mutti L, Parsons JL, Elder RH.

Genes (Basel). 2019 Apr 23;10(4). pii: E315. doi: 10.3390/genes10040315.


Characterisation of Deubiquitylating Enzymes in the Cellular Response to High-LET Ionizing Radiation and Complex DNA Damage.

Carter RJ, Nickson CM, Thompson JM, Kacperek A, Hill MA, Parsons JL.

Int J Radiat Oncol Biol Phys. 2019 Jul 1;104(3):656-665. doi: 10.1016/j.ijrobp.2019.02.053. Epub 2019 Mar 7.


NTH1 Is a New Target for Ubiquitylation-Dependent Regulation by TRIM26 Required for the Cellular Response to Oxidative Stress.

Williams SC, Parsons JL.

Mol Cell Biol. 2018 May 29;38(12). pii: e00616-17. doi: 10.1128/MCB.00616-17. Print 2018 Jun 15.


Complex DNA Damage Induced by High Linear Energy Transfer Alpha-Particles and Protons Triggers a Specific Cellular DNA Damage Response.

Carter RJ, Nickson CM, Thompson JM, Kacperek A, Hill MA, Parsons JL.

Int J Radiat Oncol Biol Phys. 2018 Mar 1;100(3):776-784. doi: 10.1016/j.ijrobp.2017.11.012. Epub 2017 Nov 14.


The Human DNA glycosylases NEIL1 and NEIL3 Excise Psoralen-Induced DNA-DNA Cross-Links in a Four-Stranded DNA Structure.

Martin PR, Couvé S, Zutterling C, Albelazi MS, Groisman R, Matkarimov BT, Parsons JL, Elder RH, Saparbaev MK.

Sci Rep. 2017 Dec 12;7(1):17438. doi: 10.1038/s41598-017-17693-4.


Misregulation of DNA damage repair pathways in HPV-positive head and neck squamous cell carcinoma contributes to cellular radiosensitivity.

Nickson CM, Moori P, Carter RJ, Rubbi CP, Parsons JL.

Oncotarget. 2017 May 2;8(18):29963-29975. doi: 10.18632/oncotarget.16265.


Ubiquitylation-dependent regulation of NEIL1 by Mule and TRIM26 is required for the cellular DNA damage response.

Edmonds MJ, Carter RJ, Nickson CM, Williams SC, Parsons JL.

Nucleic Acids Res. 2017 Jan 25;45(2):726-738. doi: 10.1093/nar/gkw959. Epub 2016 Oct 18.


Base Excision Repair, a Pathway Regulated by Posttranslational Modifications.

Carter RJ, Parsons JL.

Mol Cell Biol. 2016 May 2;36(10):1426-37. doi: 10.1128/MCB.00030-16. Print 2016 May 15. Review.


Regulation of base excision repair proteins by ubiquitylation.

Edmonds MJ, Parsons JL.

Exp Cell Res. 2014 Nov 15;329(1):132-8. doi: 10.1016/j.yexcr.2014.07.031. Epub 2014 Aug 6. Review.


Monitoring regulation of DNA repair activities of cultured cells in-gel using the comet assay.

Nickson CM, Parsons JL.

Front Genet. 2014 Jul 16;5:232. doi: 10.3389/fgene.2014.00232. eCollection 2014. Review.


ARF induction in response to DNA strand breaks is regulated by PARP1.

Orlando G, Khoronenkova SV, Dianova II, Parsons JL, Dianov GL.

Nucleic Acids Res. 2014 Feb;42(4):2320-9. doi: 10.1093/nar/gkt1185. Epub 2013 Nov 29.


Co-ordination of base excision repair and genome stability.

Parsons JL, Dianov GL.

DNA Repair (Amst). 2013 May 1;12(5):326-33. doi: 10.1016/j.dnarep.2013.02.001. Epub 2013 Mar 7. Review.


Phosphorylation of PNKP by ATM prevents its proteasomal degradation and enhances resistance to oxidative stress.

Parsons JL, Khoronenkova SV, Dianova II, Ternette N, Kessler BM, Datta PK, Dianov GL.

Nucleic Acids Res. 2012 Dec;40(22):11404-15. doi: 10.1093/nar/gks909. Epub 2012 Oct 5.


In vitro base excision repair using mammalian cell extracts.

Parsons JL, Dianov GL.

Methods Mol Biol. 2012;920:245-62. doi: 10.1007/978-1-61779-998-3_17.


Biological and therapeutic relevance of nonreplicative DNA polymerases to cancer.

Parsons JL, Nicolay NH, Sharma RA.

Antioxid Redox Signal. 2013 Mar 10;18(8):851-73. doi: 10.1089/ars.2011.4203. Epub 2012 Sep 5. Review.


ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage.

Khoronenkova SV, Dianova II, Ternette N, Kessler BM, Parsons JL, Dianov GL.

Mol Cell. 2012 Mar 30;45(6):801-13. doi: 10.1016/j.molcel.2012.01.021. Epub 2012 Feb 21.


Regulation of oxidative DNA damage repair by DNA polymerase λ and MutYH by cross-talk of phosphorylation and ubiquitination.

Markkanen E, van Loon B, Ferrari E, Parsons JL, Dianov GL, Hübscher U.

Proc Natl Acad Sci U S A. 2012 Jan 10;109(2):437-42. doi: 10.1073/pnas.1110449109. Epub 2011 Dec 27.


Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes.

Altun M, Kramer HB, Willems LI, McDermott JL, Leach CA, Goldenberg SJ, Kumar KG, Konietzny R, Fischer R, Kogan E, Mackeen MM, McGouran J, Khoronenkova SV, Parsons JL, Dianov GL, Nicholson B, Kessler BM.

Chem Biol. 2011 Nov 23;18(11):1401-12. doi: 10.1016/j.chembiol.2011.08.018.


Ubiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stability.

Meisenberg C, Tait PS, Dianova II, Wright K, Edelmann MJ, Ternette N, Tasaki T, Kessler BM, Parsons JL, Kwon YT, Dianov GL.

Nucleic Acids Res. 2012 Jan;40(2):701-11. doi: 10.1093/nar/gkr744. Epub 2011 Sep 20.

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