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Items: 1 to 20 of 31


The Expressions of Dickkopf-Related Protein 1 and Frizzled-Related Protein Are Negatively Correlated to Local Inflammation and Osteoarthritis Severity.

Huang X, Zhong L, van Helvoort E, Lafeber F, Mastbergen S, Hendriks J, Post JN, Karperien M.

Cartilage. 2019 Apr 4:1947603519841676. doi: 10.1177/1947603519841676. [Epub ahead of print]


Changes in Fluorescence Recovery After Photobleaching (FRAP) as an indicator of SOX9 transcription factor activity.

Govindaraj K, Hendriks J, Lidke DS, Karperien M, Post JN.

Biochim Biophys Acta Gene Regul Mech. 2019 Jan;1862(1):107-117. doi: 10.1016/j.bbagrm.2018.11.001. Epub 2018 Nov 20.


Different response of human chondrocytes from healthy looking areas and damaged regions to IL1β stimulation under different oxygen tension.

Huang X, Zhong L, Hendriks J, Post JN, Karperien M.

J Orthop Res. 2019 Jan;37(1):84-93. doi: 10.1002/jor.24142. Epub 2018 Oct 1.


The Effects of the WNT-Signaling Modulators BIO and PKF118-310 on the Chondrogenic Differentiation of Human Mesenchymal Stem Cells.

Huang X, Zhong L, Hendriks J, Post JN, Karperien M.

Int J Mol Sci. 2018 Feb 13;19(2). pii: E561. doi: 10.3390/ijms19020561.


Nitric Oxide Mediates Crosstalk between Interleukin 1β and WNT Signaling in Primary Human Chondrocytes by Reducing DKK1 and FRZB Expression.

Zhong L, Schivo S, Huang X, Leijten J, Karperien M, Post JN.

Int J Mol Sci. 2017 Nov 22;18(11). pii: E2491. doi: 10.3390/ijms18112491.


Oxygen-Dependent Lipid Profiles of Three-Dimensional Cultured Human Chondrocytes Revealed by MALDI-MSI.

Bakker B, Eijkel GB, Heeren RMA, Karperien M, Post JN, Cillero-Pastor B.

Anal Chem. 2017 Sep 5;89(17):9438-9444. doi: 10.1021/acs.analchem.7b02265. Epub 2017 Aug 14.


Endogenous DKK1 and FRZB Regulate Chondrogenesis and Hypertrophy in Three-Dimensional Cultures of Human Chondrocytes and Human Mesenchymal Stem Cells.

Zhong L, Huang X, Rodrigues ED, Leijten JC, Verrips T, El Khattabi M, Karperien M, Post JN.

Stem Cells Dev. 2016 Dec 1;25(23):1808-1817. Epub 2016 Oct 27.


A Qualitative Model of the Differentiation Network in Chondrocyte Maturation: A Holistic View of Chondrocyte Hypertrophy.

Kerkhofs J, Leijten J, Bolander J, Luyten FP, Post JN, Geris L.

PLoS One. 2016 Aug 31;11(8):e0162052. doi: 10.1371/journal.pone.0162052. eCollection 2016.


Modelling with ANIMO: between fuzzy logic and differential equations.

Schivo S, Scholma J, van der Vet PE, Karperien M, Post JN, van de Pol J, Langerak R.

BMC Syst Biol. 2016 Jul 27;10(1):56. doi: 10.1186/s12918-016-0286-z.


Correlation between Gene Expression and Osteoarthritis Progression in Human.

Zhong L, Huang X, Karperien M, Post JN.

Int J Mol Sci. 2016 Jul 14;17(7). pii: E1126. doi: 10.3390/ijms17071126.


Improved intra-array and interarray normalization of peptide microarray phosphorylation for phosphorylome and kinome profiling by rational selection of relevant spots.

Scholma J, Fuhler GM, Joore J, Hulsman M, Schivo S, List AF, Reinders MJ, Peppelenbosch MP, Post JN.

Sci Rep. 2016 May 26;6:26695. doi: 10.1038/srep26695.


The Regulatory Role of Signaling Crosstalk in Hypertrophy of MSCs and Human Articular Chondrocytes.

Zhong L, Huang X, Karperien M, Post JN.

Int J Mol Sci. 2015 Aug 14;16(8):19225-47. doi: 10.3390/ijms160819225. Review.


MicroRNA Levels as Prognostic Markers for the Differentiation Potential of Human Mesenchymal Stromal Cell Donors.

Georgi N, Taipaleenmaki H, Raiss CC, Groen N, Portalska KJ, van Blitterswijk C, de Boer J, Post JN, van Wijnen AJ, Karperien M.

Stem Cells Dev. 2015 Aug 15;24(16):1946-55. doi: 10.1089/scd.2014.0534. Epub 2015 Jun 17.


Differentiation of mesenchymal stem cells under hypoxia and normoxia: lipid profiles revealed by time-of-flight secondary ion mass spectrometry and multivariate analysis.

Georgi N, Cillero-Pastor B, Eijkel GB, Periyasamy PC, Kiss A, van Blitterswijk C, Post JN, Heeren RM, Karperien M.

Anal Chem. 2015 Apr 7;87(7):3981-8. doi: 10.1021/acs.analchem.5b00114. Epub 2015 Mar 19.


Engineering cartilage tissue by pellet coculture of chondrocytes and mesenchymal stromal cells.

Wu L, Post JN, Karperien M.

Methods Mol Biol. 2015;1226:31-41. doi: 10.1007/978-1-4939-1619-1_4.


Metabolic programming of mesenchymal stromal cells by oxygen tension directs chondrogenic cell fate.

Leijten J, Georgi N, Moreira Teixeira L, van Blitterswijk CA, Post JN, Karperien M.

Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13954-9. doi: 10.1073/pnas.1410977111. Epub 2014 Sep 9.


Modeling biological pathway dynamics with timed automata.

Schivo S, Scholma J, Wanders B, Urquidi Camacho RA, van der Vet PE, Karperien M, Langerak R, van de Pol J, Post JN.

IEEE J Biomed Health Inform. 2014 May;18(3):832-9. doi: 10.1109/JBHI.2013.2292880.


GREM1, FRZB and DKK1 mRNA levels correlate with osteoarthritis and are regulated by osteoarthritis-associated factors.

Leijten JC, Bos SD, Landman EB, Georgi N, Jahr H, Meulenbelt I, Post JN, van Blitterswijk CA, Karperien M.

Arthritis Res Ther. 2013 Sep 19;15(5):R126. doi: 10.1186/ar4306.


Biological networks 101: computational modeling for molecular biologists.

Scholma J, Schivo S, Urquidi Camacho RA, van de Pol J, Karperien M, Post JN.

Gene. 2014 Jan 1;533(1):379-84. doi: 10.1016/j.gene.2013.10.010. Epub 2013 Oct 12.


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