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Items: 1 to 20 of 47

1.

Design, synthesis and biological evaluation of novel DNA gyrase inhibitors and their siderophore mimic conjugates.

Lamut A, Cruz CD, Skok Ž, Barančoková M, Zidar N, Zega A, Mašič LP, Ilaš J, Tammela P, Kikelj D, Tomašič T.

Bioorg Chem. 2019 Dec 23;95:103550. doi: 10.1016/j.bioorg.2019.103550. [Epub ahead of print]

PMID:
31911309
2.

Dual Escherichia coli DNA Gyrase A and B Inhibitors with Antibacterial Activity.

Fois B, Skok Ž, Tomašič T, Ilaš J, Zidar N, Zega A, Peterlin Mašič L, Szili P, Draskovits G, Nyerges Á, Pál C, Kikelj D.

ChemMedChem. 2019 Nov 13. doi: 10.1002/cmdc.201900607. [Epub ahead of print]

PMID:
31721445
3.

Dual Inhibitors of Human DNA Topoisomerase II and Other Cancer-Related Targets.

Skok Ž, Zidar N, Kikelj D, Ilaš J.

J Med Chem. 2019 Oct 21. doi: 10.1021/acs.jmedchem.9b00726. [Epub ahead of print]

PMID:
31592646
4.

New N-phenyl-4,5-dibromopyrrolamides as DNA gyrase B inhibitors.

Zidar N, Macut H, Tomašič T, Peterlin Mašič L, Ilaš J, Zega A, Tammela P, Kikelj D.

Medchemcomm. 2019 May 20;10(6):1007-1017. doi: 10.1039/c9md00224c. eCollection 2019 Jun 1.

PMID:
31303999
5.

An optimised series of substituted N-phenylpyrrolamides as DNA gyrase B inhibitors.

Tiz DB, Skok Ž, Durcik M, Tomašič T, Mašič LP, Ilaš J, Zega A, Draskovits G, Révész T, Nyerges Á, Pál C, Cruz CD, Tammela P, Žigon D, Kikelj D, Zidar N.

Eur J Med Chem. 2019 Apr 1;167:269-290. doi: 10.1016/j.ejmech.2019.02.004. Epub 2019 Feb 10.

PMID:
30776691
6.

ATP-competitive DNA gyrase and topoisomerase IV inhibitors as antibacterial agents.

Durcik M, Tomašič T, Zidar N, Zega A, Kikelj D, Mašič LP, Ilaš J.

Expert Opin Ther Pat. 2019 Mar;29(3):171-180. doi: 10.1080/13543776.2019.1575362. Epub 2019 Feb 6. Review.

PMID:
30686070
7.

Heterocyclic electrophiles as new MurA inhibitors.

Keeley A, Ábrányi-Balogh P, Hrast M, Imre T, Ilaš J, Gobec S, Keserű GM.

Arch Pharm (Weinheim). 2018 Dec;351(12):e1800184. doi: 10.1002/ardp.201800184. Epub 2018 Nov 21.

PMID:
30461051
8.

Synthesis and Evaluation of Spumigin Analogues Library with Thrombin Inhibitory Activity.

Žula A, Będziak I, Kikelj D, Ilaš J.

Mar Drugs. 2018 Oct 27;16(11). pii: E413. doi: 10.3390/md16110413.

9.

A road map for prioritizing warheads for cysteine targeting covalent inhibitors.

Ábrányi-Balogh P, Petri L, Imre T, Szijj P, Scarpino A, Hrast M, Mitrović A, Fonovič UP, Németh K, Barreteau H, Roper DI, Horváti K, Ferenczy GG, Kos J, Ilaš J, Gobec S, Keserű GM.

Eur J Med Chem. 2018 Dec 5;160:94-107. doi: 10.1016/j.ejmech.2018.10.010. Epub 2018 Oct 6.

PMID:
30321804
10.

Recent progress in the discovery and development of DNA gyrase B inhibitors.

Barančoková M, Kikelj D, Ilaš J.

Future Med Chem. 2018 May 1;10(10):1207-1227. doi: 10.4155/fmc-2017-0257. Epub 2018 May 22. Review.

PMID:
29787300
11.

New N-phenylpyrrolamide DNA gyrase B inhibitors: Optimization of efficacy and antibacterial activity.

Durcik M, Lovison D, Skok Ž, Durante Cruz C, Tammela P, Tomašič T, Benedetto Tiz D, Draskovits G, Nyerges Á, Pál C, Ilaš J, Peterlin Mašič L, Kikelj D, Zidar N.

Eur J Med Chem. 2018 Jun 25;154:117-132. doi: 10.1016/j.ejmech.2018.05.011. Epub 2018 May 10.

12.

Discovery of d-amino acid oxidase inhibitors based on virtual screening against the lid-open enzyme conformation.

Szilágyi B, Skok Ž, Rácz A, Frlan R, Ferenczy GG, Ilaš J, Keserű GM.

Bioorg Med Chem Lett. 2018 Jun 1;28(10):1693-1698. doi: 10.1016/j.bmcl.2018.04.048. Epub 2018 Apr 20.

PMID:
29699925
13.

Discovery of isatin and 1H-indazol-3-ol derivatives as d-amino acid oxidase (DAAO) inhibitors.

Szilágyi B, Kovács P, Ferenczy GG, Rácz A, Németh K, Visy J, Szabó P, Ilas J, Balogh GT, Monostory K, Vincze I, Tábi T, Szökő É, Keserű GM.

Bioorg Med Chem. 2018 May 1;26(8):1579-1587. doi: 10.1016/j.bmc.2018.02.004. Epub 2018 Feb 8.

PMID:
29472125
14.

Influence of different classes of crosslinkers on alginate polyelectrolyte nanoparticle formation, thermodynamics and characteristics.

Mirtič J, Ilaš J, Kristl J.

Carbohydr Polym. 2018 Feb 1;181:93-102. doi: 10.1016/j.carbpol.2017.10.040. Epub 2017 Oct 13.

PMID:
29254056
15.

Design, synthesis, and biological evaluation of 1-ethyl-3-(thiazol-2-yl)urea derivatives as Escherichia coli DNA gyrase inhibitors.

Tomašič T, Barančoková M, Zidar N, Ilaš J, Tammela P, Kikelj D.

Arch Pharm (Weinheim). 2018 Jan;351(1). doi: 10.1002/ardp.201700333. Epub 2017 Dec 14.

PMID:
29239018
16.

Synthesis and Evaluation of N-Phenylpyrrolamides as DNA Gyrase B Inhibitors.

Durcik M, Tammela P, Barančoková M, Tomašič T, Ilaš J, Kikelj D, Zidar N.

ChemMedChem. 2018 Jan 22;13(2):186-198. doi: 10.1002/cmdc.201700549. Epub 2018 Jan 8.

PMID:
29206345
17.

Structure-activity relationships and molecular docking studies of chromene and chromene based azo chromophores: A novel series of potent antimicrobial and anticancer agents.

Afifi TH, Okasha RM, Ahmed HEA, Ilaš J, Saleh T, Abd-El-Aziz AS.

EXCLI J. 2017 Jun 19;16:868-902. doi: 10.17179/excli2017-356. eCollection 2017.

18.

Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels.

Zidar N, Žula A, Tomašič T, Rogers M, Kirby RW, Tytgat J, Peigneur S, Kikelj D, Ilaš J, Mašič LP.

Eur J Med Chem. 2017 Oct 20;139:232-241. doi: 10.1016/j.ejmech.2017.08.015. Epub 2017 Aug 7.

PMID:
28802123
19.

Design, Synthesis, and Evaluation of Novel Tyrosine-Based DNA Gyrase B Inhibitors.

Cotman AE, Trampuž M, Brvar M, Kikelj D, Ilaš J, Peterlin-Mašič L, Montalvão S, Tammela P, Frlan R.

Arch Pharm (Weinheim). 2017 Aug;350(8). doi: 10.1002/ardp.201700087. Epub 2017 Jun 16.

PMID:
28621824
20.

Discovery of substituted oxadiazoles as a novel scaffold for DNA gyrase inhibitors.

Jakopin Ž, Ilaš J, Barančoková M, Brvar M, Tammela P, Sollner Dolenc M, Tomašič T, Kikelj D.

Eur J Med Chem. 2017 Apr 21;130:171-184. doi: 10.1016/j.ejmech.2017.02.046. Epub 2017 Feb 22.

PMID:
28246042

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