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Items: 1 to 20 of 59

1.

GABA allosteric modulators: An overview of recent developments in non-benzodiazepine modulators.

Solomon VR, Tallapragada VJ, Chebib M, Johnston GAR, Hanrahan JR.

Eur J Med Chem. 2019 Jun 1;171:434-461. doi: 10.1016/j.ejmech.2019.03.043. Epub 2019 Mar 23. Review.

PMID:
30928713
2.

Optimising the transient expression of GABA(A) receptors in adherent HEK293 cells.

Devenish SO, Johnston GAR, Chebib M, Hanrahan JR.

Protein Expr Purif. 2019 Feb;154:7-15. doi: 10.1016/j.pep.2018.09.012. Epub 2018 Sep 21.

PMID:
30248449
3.

Exploring the Binding of Barbital to a Synthetic Macrocyclic Receptor. A Charge Density Study.

Du JJ, Hanrahan JR, Solomon VR, Williams PA, Groundwater PW, Overgaard J, Platts JA, Hibbs DE.

J Phys Chem A. 2018 Mar 22;122(11):3031-3044. doi: 10.1021/acs.jpca.7b11674. Epub 2018 Mar 13.

PMID:
29481082
4.

The flavonoid, 2'-methoxy-6-methylflavone, affords neuroprotection following focal cerebral ischaemia.

Clarkson AN, Boothman-Burrell L, Dósa Z, Nagaraja RY, Jin L, Parker K, van Nieuwenhuijzen PS, Neumann S, Gowing EK, Gavande N, Ahring PK, Holm MM, Hanrahan JR, Nicolazzo JA, Jensen K, Chebib M.

J Cereb Blood Flow Metab. 2019 Jul;39(7):1266-1282. doi: 10.1177/0271678X18755628. Epub 2018 Jan 29.

PMID:
29376464
5.

Molecular docking and antiamnesic effects of nepitrin isolated from Rosmarinus officinalis on scopolamine-induced memory impairment in mice.

Karim N, Khan I, Abdelhalim A, Abdel-Halim H, Hanrahan JR.

Biomed Pharmacother. 2017 Dec;96:700-709. doi: 10.1016/j.biopha.2017.09.121. Epub 2017 Nov 6.

PMID:
29040957
6.

GABA-ρ receptors: distinctive functions and molecular pharmacology.

Naffaa MM, Hung S, Chebib M, Johnston GAR, Hanrahan JR.

Br J Pharmacol. 2017 Jul;174(13):1881-1894. doi: 10.1111/bph.13768. Epub 2017 Apr 12. Review.

7.

Spontaneous Adverse Event Reports Associated with Zolpidem in the United States 2003-2012.

Wong CK, Marshall NS, Grunstein RR, Ho SS, Fois RA, Hibbs DE, Hanrahan JR, Saini B.

J Clin Sleep Med. 2017 Feb 15;13(2):223-234. doi: 10.5664/jcsm.6452.

8.

Study of the Activity and Possible Mechanism of Action of a Reversible Inhibitor of Recombinant Human KAT-2: A Promising Lead in Neurodegenerative and Cognitive Disorders.

Nematollahi A, Sun G, Jayawickrama GS, Hanrahan JR, Church WB.

Molecules. 2016 Jun 29;21(7). pii: E856. doi: 10.3390/molecules21070856.

9.

Investigating the Role of Loop C Hydrophilic Residue 'T244' in the Binding Site of ρ1 GABAC Receptors via Site Mutation and Partial Agonism.

Naffaa MM, Absalom N, Solomon VR, Chebib M, Hibbs DE, Hanrahan JR.

PLoS One. 2016 May 31;11(5):e0156618. doi: 10.1371/journal.pone.0156618. eCollection 2016.

10.

Structure of the PLP-Form of the Human Kynurenine Aminotransferase II in a Novel Spacegroup at 1.83 Å Resolution.

Nematollahi A, Sun G, Harrop SJ, Hanrahan JR, Church WB.

Int J Mol Sci. 2016 Mar 25;17(4):446. doi: 10.3390/ijms17040446.

11.

The Direct Actions of GABA, 2'-Methoxy-6-Methylflavone and General Anaesthetics at β3γ2L GABAA Receptors: Evidence for Receptors with Different Subunit Stoichiometries.

Chua HC, Absalom NL, Hanrahan JR, Viswas R, Chebib M.

PLoS One. 2015 Oct 23;10(10):e0141359. doi: 10.1371/journal.pone.0141359. eCollection 2015.

12.

Comparison of templates for homology model of ρ1 GABAC receptors: More insights to the orthosteric binding site's structure and functionality.

Naffaa MM, Chebib M, Hibbs DE, Hanrahan JR.

J Mol Graph Model. 2015 Nov;62:43-55. doi: 10.1016/j.jmgm.2015.09.002. Epub 2015 Sep 3.

PMID:
26363367
13.

Kynurenine Aminotransferases and the Prospects of Inhibitors for the Treatment of Schizophrenia.

Jayawickrama GS, Sadig RR, Sun G, Nematollahi A, Nadvi NA, Hanrahan JR, Gorrell MD, Church WB.

Curr Med Chem. 2015;22(24):2902-18. Review.

PMID:
26051411
14.

Interactions of flavonoids with ionotropic GABA receptors.

Hanrahan JR, Chebib M, Johnston GA.

Adv Pharmacol. 2015;72:189-200. doi: 10.1016/bs.apha.2014.10.007. Epub 2014 Dec 4. Review.

PMID:
25600371
15.

Metabolomic Approaches to Defining the Role(s) of GABAρ Receptors in the Brain.

Rae C, Nasrallah FA, Balcar VJ, Rowlands BD, Johnston GA, Hanrahan JR.

J Neuroimmune Pharmacol. 2015 Sep;10(3):445-56. doi: 10.1007/s11481-014-9579-4. Epub 2015 Jan 11.

PMID:
25577264
16.

GABAA receptors containing ρ1 subunits contribute to in vivo effects of ethanol in mice.

Blednov YA, Benavidez JM, Black M, Leiter CR, Osterndorff-Kahanek E, Johnson D, Borghese CM, Hanrahan JR, Johnston GA, Chebib M, Harris RA.

PLoS One. 2014 Jan 16;9(1):e85525. doi: 10.1371/journal.pone.0085525. eCollection 2014.

17.

Modulation of ionotropic GABA receptors by 6-methoxyflavanone and 6-methoxyflavone.

Hall BJ, Karim N, Chebib M, Johnston GA, Hanrahan JR.

Neurochem Res. 2014 Jun;39(6):1068-78. doi: 10.1007/s11064-013-1157-2. Epub 2013 Sep 29.

PMID:
24078264
18.

Γ-aminobutyric acid(C) (GABAC) selective antagonists derived from the bioisosteric modification of 4-aminocyclopent-1-enecarboxylic acid: amides and hydroxamates.

Locock KE, Yamamoto I, Tran P, Hanrahan JR, Chebib M, Johnston GA, Allan RD.

J Med Chem. 2013 Jul 11;56(13):5626-30. doi: 10.1021/jm4006548. Epub 2013 Jun 27.

PMID:
23755849
19.

Ethnopharmacological and bioactivity guided investigation of five TCM anticancer herbs.

Meng QX, Roubin RH, Hanrahan JR.

J Ethnopharmacol. 2013 Jun 21;148(1):229-38. doi: 10.1016/j.jep.2013.04.014. Epub 2013 Apr 23.

PMID:
23623820
20.

Design, Synthesis, and Pharmacological Evaluation of Fluorescent and Biotinylated Antagonists of ρ1 GABAC Receptors.

Gavande N, Kim HL, Doddareddy MR, Johnston GA, Chebib M, Hanrahan JR.

ACS Med Chem Lett. 2013 Feb 18;4(4):402-7. doi: 10.1021/ml300476v. eCollection 2013 Apr 11.

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