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Items: 1 to 20 of 36

1.

Efficient CRISPR/Cas9 Gene Editing in Uncultured Naive Mouse T Cells for In Vivo Studies.

Nüssing S, House IG, Kearney CJ, Chen AXY, Vervoort SJ, Beavis PA, Oliaro J, Johnstone RW, Trapani JA, Parish IA.

J Immunol. 2020 Mar 9. pii: ji1901396. doi: 10.4049/jimmunol.1901396. [Epub ahead of print]

PMID:
32152070
2.

The Immuno-Modulatory Effects of Inhibitor of Apoptosis Protein Antagonists in Cancer Immunotherapy.

Michie J, Kearney CJ, Hawkins ED, Silke J, Oliaro J.

Cells. 2020 Jan 14;9(1). pii: E207. doi: 10.3390/cells9010207. Review.

3.

PTPN2 phosphatase deletion in T cells promotes anti-tumour immunity and CAR T-cell efficacy in solid tumours.

Wiede F, Lu KH, Du X, Liang S, Hochheiser K, Dodd GT, Goh PK, Kearney C, Meyran D, Beavis PA, Henderson MA, Park SL, Waithman J, Zhang S, Zhang ZY, Oliaro J, Gebhardt T, Darcy PK, Tiganis T.

EMBO J. 2020 Jan 15;39(2):e103637. doi: 10.15252/embj.2019103637. Epub 2019 Dec 5.

4.

Natural Killer Cells Suppress T Cell-Associated Tumor Immune Evasion.

Freeman AJ, Vervoort SJ, Ramsbottom KM, Kelly MJ, Michie J, Pijpers L, Johnstone RW, Kearney CJ, Oliaro J.

Cell Rep. 2019 Sep 10;28(11):2784-2794.e5. doi: 10.1016/j.celrep.2019.08.017.

5.

Protection from EAE in DOCK8 mutant mice occurs despite increased Th17 cell frequencies in the periphery.

Wilson AS, Law HD, Knobbe-Thomsen CB, Kearney CJ, Oliaro J, Binsfeld C, Burgio G, Starrs L, Brenner D, Randall KL, Brüstle A.

Eur J Immunol. 2019 May;49(5):770-781. doi: 10.1002/eji.201847960. Epub 2019 Feb 20.

PMID:
30729501
6.

A novel immunogenic mouse model of melanoma for the preclinical assessment of combination targeted and immune-based therapy.

Lelliott EJ, Cullinane C, Martin CA, Walker R, Ramsbottom KM, Souza-Fonseca-Guimaraes F, Abuhammad S, Michie J, Kirby L, Young RJ, Slater A, Lau P, Meeth K, Oliaro J, Haynes N, McArthur GA, Sheppard KE.

Sci Rep. 2019 Feb 4;9(1):1225. doi: 10.1038/s41598-018-37883-y.

7.

Antagonism of IAPs Enhances CAR T-cell Efficacy.

Michie J, Beavis PA, Freeman AJ, Vervoort SJ, Ramsbottom KM, Narasimhan V, Lelliott EJ, Lalaoui N, Ramsay RG, Johnstone RW, Silke J, Darcy PK, Voskoboinik I, Kearney CJ, Oliaro J.

Cancer Immunol Res. 2019 Feb;7(2):183-192. doi: 10.1158/2326-6066.CIR-18-0428. Epub 2019 Jan 16.

8.

Tumor immune evasion arises through loss of TNF sensitivity.

Kearney CJ, Vervoort SJ, Hogg SJ, Ramsbottom KM, Freeman AJ, Lalaoui N, Pijpers L, Michie J, Brown KK, Knight DA, Sutton V, Beavis PA, Voskoboinik I, Darcy PK, Silke J, Trapani JA, Johnstone RW, Oliaro J.

Sci Immunol. 2018 May 18;3(23). pii: eaar3451. doi: 10.1126/sciimmunol.aar3451.

PMID:
29776993
9.

DOCK8 Drives Src-Dependent NK Cell Effector Function.

Kearney CJ, Vervoort SJ, Ramsbottom KM, Freeman AJ, Michie J, Peake J, Casanova JL, Picard C, Tangye SG, Ma CS, Johnstone RW, Randall KL, Oliaro J.

J Immunol. 2017 Aug 9. pii: ji1700751. doi: 10.4049/jimmunol.1700751. [Epub ahead of print]

PMID:
28794229
10.

PD-L1 and IAPs co-operate to protect tumors from cytotoxic lymphocyte-derived TNF.

Kearney CJ, Lalaoui N, Freeman AJ, Ramsbottom KM, Silke J, Oliaro J.

Cell Death Differ. 2017 Oct;24(10):1705-1716. doi: 10.1038/cdd.2017.94. Epub 2017 Jun 30.

11.

DOCK8 regulates signal transduction events to control immunity.

Kearney CJ, Randall KL, Oliaro J.

Cell Mol Immunol. 2017 May;14(5):406-411. doi: 10.1038/cmi.2017.9. Epub 2017 Apr 3. Review.

12.

Loss of DNAM-1 ligand expression by acute myeloid leukemia cells renders them resistant to NK cell killing.

Kearney CJ, Ramsbottom KM, Voskoboinik I, Darcy PK, Oliaro J.

Oncoimmunology. 2016 Jun 27;5(8):e1196308. doi: 10.1080/2162402X.2016.1196308. eCollection 2016 Aug.

13.

The Role of the immunological Synapse Formed by Cytotoxic Lymphocytes in Immunodeficiency and Anti-Tumor immunity.

Kearney CJ, Brennan AJ, Darcy PK, Oliaro J.

Crit Rev Immunol. 2015;35(4):325-47. Review.

PMID:
26757394
14.

Lethal giant larvae-1 deficiency enhances the CD8(+) effector T-cell response to antigen challenge in vivo.

Ramsbottom KM, Sacirbegovic F, Hawkins ED, Kallies A, Belz GT, Van Ham V, Haynes NM, Durrant MJ, Humbert PO, Russell SM, Oliaro J.

Immunol Cell Biol. 2016 Mar;94(3):306-11. doi: 10.1038/icb.2015.82. Epub 2015 Sep 22.

PMID:
26391810
15.

Asymmetric cell division during T cell development controls downstream fate.

Pham K, Shimoni R, Charnley M, Ludford-Menting MJ, Hawkins ED, Ramsbottom K, Oliaro J, Izon D, Ting SB, Reynolds J, Lythe G, Molina-Paris C, Melichar H, Robey E, Humbert PO, Gu M, Russell SM.

J Cell Biol. 2015 Sep 14;210(6):933-50. doi: 10.1083/jcb.201502053.

16.

A method for detecting intracellular perforin in mouse lymphocytes.

Brennan AJ, House IG, Oliaro J, Ramsbottom KM, Hagn M, Yagita H, Trapani JA, Voskoboinik I.

J Immunol. 2014 Dec 1;193(11):5744-50. doi: 10.4049/jimmunol.1402207. Epub 2014 Oct 27.

17.

Lethal giant larvae 1 tumour suppressor activity is not conserved in models of mammalian T and B cell leukaemia.

Hawkins ED, Oliaro J, Ramsbottom KM, Ting SB, Sacirbegovic F, Harvey M, Kinwell T, Ghysdael J, Johnstone RW, Humbert PO, Russell SM.

PLoS One. 2014 Jan 27;9(1):e87376. doi: 10.1371/journal.pone.0087376. eCollection 2014.

18.

Cutting edge: DNAX accessory molecule 1-deficient CD8+ T cells display immunological synapse defects that impair antitumor immunity.

Ramsbottom KM, Hawkins ED, Shimoni R, McGrath M, Chan CJ, Russell SM, Smyth MJ, Oliaro J.

J Immunol. 2014 Jan 15;192(2):553-7. doi: 10.4049/jimmunol.1302197. Epub 2013 Dec 13.

19.

Regulation of asymmetric cell division and polarity by Scribble is not required for humoral immunity.

Hawkins ED, Oliaro J, Kallies A, Belz GT, Filby A, Hogan T, Haynes N, Ramsbottom KM, Van Ham V, Kinwell T, Seddon B, Davies D, Tarlinton D, Lew AM, Humbert PO, Russell SM.

Nat Commun. 2013;4:1801. doi: 10.1038/ncomms2796.

PMID:
23653213
20.

Interplay of polarity proteins and GTPases in T-lymphocyte function.

Fung I, Russell SM, Oliaro J.

Clin Dev Immunol. 2012;2012:417485. doi: 10.1155/2012/417485. Epub 2012 Feb 22. Review.

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