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Items: 1 to 20 of 214

1.

Structural and functional characterisation of a novel peptide from the Australian sea anemone Actinia tenebrosa.

Elnahriry KA, Wai DCC, Krishnarjuna B, Badawy NN, Chittoor B, MacRaild CA, Williams-Noonan BJ, Surm JM, Chalmers DK, Zhang AH, Peigneur S, Mobli M, Tytgat J, Prentis P, Norton RS.

Toxicon. 2019 Jul 11. pii: S0041-0101(19)30405-2. doi: 10.1016/j.toxicon.2019.07.002. [Epub ahead of print]

PMID:
31302115
2.

Chemical Synthesis, Proper Folding, Nav Channel Selectivity Profile and Analgesic Properties of the Spider Peptide Phlotoxin 1.

Nicolas S, Zoukimian C, Bosmans F, Montnach J, Diochot S, Cuypers E, De Waard S, Béroud R, Mebs D, Craik D, Boturyn D, Lazdunski M, Tytgat J, De Waard M.

Toxins (Basel). 2019 Jun 21;11(6). pii: E367. doi: 10.3390/toxins11060367.

3.

The birth and death of toxins with distinct functions: a case study in the sea anemone Nematostella.

Sachkova MY, Singer SA, Macrander J, Reitzel AM, Peigneur S, Tytgat J, Moran Y.

Mol Biol Evol. 2019 May 27. pii: msz132. doi: 10.1093/molbev/msz132. [Epub ahead of print]

PMID:
31134275
4.

Antinociceptive effects of new pyrazoles compounds mediated by the ASIC-1α channel, TRPV-1 and μMOR receptors.

Florentino IF, Silva DPB, Cardoso CS, Menegatti R, de Carvalho FS, Lião LM, Pinto PM, Peigneur S, Costa EA, Tytgat J.

Biomed Pharmacother. 2019 Jul;115:108915. doi: 10.1016/j.biopha.2019.108915. Epub 2019 May 3.

5.

Jaburetox, a natural insecticide derived from Jack Bean Urease, activates voltage-gated sodium channels to modulate insect behavior.

Dos Santos DS, Zanatta AP, Martinelli AHS, Rosa ME, de Oliveira RS, Pinto PM, Peigneur S, Tytgat J, Orchard I, Lange AB, Carlini CR, Dal Belo CA.

Pestic Biochem Physiol. 2019 Jan;153:67-76. doi: 10.1016/j.pestbp.2018.11.003. Epub 2018 Nov 5.

PMID:
30744898
6.

A Centipede Toxin Family Defines an Ancient Class of CSαβ Defensins.

Dash TS, Shafee T, Harvey PJ, Zhang C, Peigneur S, Deuis JR, Vetter I, Tytgat J, Anderson MA, Craik DJ, Durek T, Undheim EAB.

Structure. 2019 Feb 5;27(2):315-326.e7. doi: 10.1016/j.str.2018.10.022. Epub 2018 Dec 13.

PMID:
30554841
7.

Biochemical characterization of the venom of Central American scorpion Didymocentrus krausi Francke, 1978 (Diplocentridae) and its toxic effects in vivo and in vitro.

Rojas-Azofeifa D, Sasa M, Lomonte B, Diego-García E, Ortiz N, Bonilla F, Murillo R, Tytgat J, Díaz C.

Comp Biochem Physiol C Toxicol Pharmacol. 2019 Mar;217:54-67. doi: 10.1016/j.cbpc.2018.11.021. Epub 2018 Dec 2.

PMID:
30517877
8.

Where cone snails and spiders meet: design of small cyclic sodium-channel inhibitors.

Peigneur S, Cheneval O, Maiti M, Leipold E, Heinemann SH, Lescrinier E, Herdewijn P, De Lima ME, Craik DJ, Schroeder CI, Tytgat J.

FASEB J. 2019 Mar;33(3):3693-3703. doi: 10.1096/fj.201801909R. Epub 2018 Dec 3.

PMID:
30509130
9.

Electrophysiological characterization of Tityus obscurus β toxin 1 (To1) on Na+-channel isoforms.

Tibery DV, Campos LA, Mourão CBF, Peigneur S, E Carvalho AC, Tytgat J, Schwartz EF.

Biochim Biophys Acta Biomembr. 2019 Jan;1861(1):142-150. doi: 10.1016/j.bbamem.2018.08.005. Epub 2018 Aug 14.

PMID:
30463697
10.

Evaluation of the suitability of ionic liquid-based liquid-liquid microextractions for blood protein removal.

De Boeck M, Moreels L, Dehaen W, Tytgat J, Cuypers E.

J Pharm Biomed Anal. 2019 Feb 5;164:57-61. doi: 10.1016/j.jpba.2018.10.019. Epub 2018 Oct 10.

PMID:
30343244
11.

AbeTx1 Is a Novel Sea Anemone Toxin with a Dual Mechanism of Action on Shaker-Type K⁺ Channels Activation.

B Orts DJ, Peigneur S, Silva-Gonçalves LC, Arcisio-Miranda M, P W Bicudo JE, Tytgat J.

Mar Drugs. 2018 Oct 1;16(10). pii: E360. doi: 10.3390/md16100360.

12.

KV1.2 channel-specific blocker from Mesobuthus eupeus scorpion venom: Structural basis of selectivity.

Kuzmenkov AI, Nekrasova OV, Peigneur S, Tabakmakher VM, Gigolaev AM, Fradkov AF, Kudryashova KS, Chugunov AO, Efremov RG, Tytgat J, Feofanov AV, Vassilevski AA.

Neuropharmacology. 2018 Dec;143:228-238. doi: 10.1016/j.neuropharm.2018.09.030. Epub 2018 Sep 22.

PMID:
30248306
13.

Phoneutria nigriventer Spider Toxin PnTx2-1 (δ-Ctenitoxin-Pn1a) Is a Modulator of Sodium Channel Gating.

Peigneur S, Paiva ALB, Cordeiro MN, Borges MH, Diniz MRV, de Lima ME, Tytgat J.

Toxins (Basel). 2018 Aug 21;10(9). pii: E337. doi: 10.3390/toxins10090337.

14.

Subtype Specificity of β-Toxin Tf1a from Tityus fasciolatus in Voltage Gated Sodium Channels.

Mata DOD, Tibery DV, Campos LA, Camargos TS, Peigneur S, Tytgat J, Schwartz EF.

Toxins (Basel). 2018 Aug 22;10(9). pii: E339. doi: 10.3390/toxins10090339.

15.

PHAB toxins: a unique family of predatory sea anemone toxins evolving via intra-gene concerted evolution defines a new peptide fold.

Madio B, Peigneur S, Chin YKY, Hamilton BR, Henriques ST, Smith JJ, Cristofori-Armstrong B, Dekan Z, Boughton BA, Alewood PF, Tytgat J, King GF, Undheim EAB.

Cell Mol Life Sci. 2018 Dec;75(24):4511-4524. doi: 10.1007/s00018-018-2897-6. Epub 2018 Aug 14.

PMID:
30109357
16.

Refined structure of BeM9 reveals arginine hand, an overlooked structural motif in scorpion toxins affecting sodium channels.

Kuldyushev NA, Mineev KS, Berkut AA, Peigneur S, Arseniev AS, Tytgat J, Grishin EV, Vassilevski AA.

Proteins. 2018 Oct;86(10):1117-1122. doi: 10.1002/prot.25583. Epub 2018 Sep 8.

PMID:
30007037
17.

Phoneutria nigriventer venom: A pharmacological treasure.

Peigneur S, de Lima ME, Tytgat J.

Toxicon. 2018 Sep 1;151:96-110. doi: 10.1016/j.toxicon.2018.07.008. Epub 2018 Jul 10. Review.

PMID:
30003916
18.

Synthesis, folding, structure and activity of a predicted peptide from the sea anemone Oulactis sp. with an ShKT fold.

Krishnarjuna B, Villegas-Moreno J, Mitchell ML, Csoti A, Peigneur S, Amero C, Pennington MW, Tytgat J, Panyi G, Norton RS.

Toxicon. 2018 Aug;150:50-59. doi: 10.1016/j.toxicon.2018.05.006. Epub 2018 May 19.

PMID:
29772211
19.

Gating modifier toxins isolated from spider venom: Modulation of voltage-gated sodium channels and the role of lipid membranes.

Agwa AJ, Peigneur S, Chow CY, Lawrence N, Craik DJ, Tytgat J, King GF, Henriques ST, Schroeder CI.

J Biol Chem. 2018 Jun 8;293(23):9041-9052. doi: 10.1074/jbc.RA118.002553. Epub 2018 Apr 27.

20.

Evaluation of 11 ionic liquids as potential extraction solvents for benzodiazepines from whole blood using liquid-liquid microextraction combined with LC-MS/MS.

De Boeck M, Damilano G, Dehaen W, Tytgat J, Cuypers E.

Talanta. 2018 Jul 1;184:369-374. doi: 10.1016/j.talanta.2018.03.001. Epub 2018 Mar 6.

PMID:
29674056

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