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Items: 1 to 20 of 88

1.

Cancer Metastasis: The Role of the Extracellular Matrix and the Heparan Sulfate Proteoglycan Perlecan.

Elgundi Z, Papanicolaou M, Major G, Cox TR, Melrose J, Whitelock JM, Farrugia BL.

Front Oncol. 2020 Jan 17;9:1482. doi: 10.3389/fonc.2019.01482. eCollection 2019. Review.

2.

Spatiotemporal Expression of 3-B-3(-) and 7-D-4 Chondroitin Sulfation, Tissue Remodeling, and Attempted Repair in an Ovine Model of Intervertebral Disc Degeneration.

Farrugia B, Smith SM, Shu CC, Melrose J.

Cartilage. 2019 Oct 3:1947603519876354. doi: 10.1177/1947603519876354. [Epub ahead of print]

PMID:
31578084
3.

Efficacy of administered mesenchymal stem cells in the initiation and co-ordination of repair processes by resident disc cells in an ovine (Ovis aries) large destabilizing lesion model of experimental disc degeneration.

Shu CC, Dart A, Bell R, Dart C, Clarke E, Smith MM, Little CB, Melrose J.

JOR Spine. 2018 Oct 10;1(4):e1037. doi: 10.1002/jsp2.1037. eCollection 2018 Dec.

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Type XI collagen-perlecan-HS interactions stabilise the pericellular matrix of annulus fibrosus cells and chondrocytes providing matrix stabilisation and homeostasis.

Smith SM, Melrose J.

J Mol Histol. 2019 Jun;50(3):285-294. doi: 10.1007/s10735-019-09823-1. Epub 2019 Apr 16.

PMID:
30993430
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11.

Elevated hypertrophy, growth plate maturation, glycosaminoglycan deposition, and exostosis formation in the Hspg2 exon 3 null mouse intervertebral disc.

Shu CC, Smith SM, Little CB, Melrose J.

Biochem J. 2019 Jan 18;476(2):225-243. doi: 10.1042/BCJ20180695.

PMID:
30563944
12.

A Perspective on the Potential Utility of a Viscosupplement Multifunctional Biotherapeutic: Proteoglycan-4: From mere lubricant to regulator of tissue homeostasis and inflammation.

Melrose J.

Bioessays. 2019 Jan;41(1):e1800215. doi: 10.1002/bies.201800215. Epub 2018 Nov 30. No abstract available.

PMID:
30500085
13.

Glycans and glycosaminoglycans in neurobiology: key regulators of neuronal cell function and fate.

Hayes AJ, Melrose J.

Biochem J. 2018 Aug 16;475(15):2511-2545. doi: 10.1042/BCJ20180283. Review.

PMID:
30115748
15.

Macrophage polarization contributes to local inflammation and structural change in the multifidus muscle after intervertebral disc injury.

James G, Sluka KA, Blomster L, Hall L, Schmid AB, Shu CC, Little CB, Melrose J, Hodges PW.

Eur Spine J. 2018 Aug;27(8):1744-1756. doi: 10.1007/s00586-018-5652-7. Epub 2018 Jun 12.

PMID:
29948327
16.

Concise Review: Stem/Progenitor Cell Proteoglycans Decorated with 7-D-4, 4-C-3, and 3-B-3(-) Chondroitin Sulfate Motifs Are Morphogenetic Markers of Tissue Development.

Hayes AJ, Smith SM, Caterson B, Melrose J.

Stem Cells. 2018 Oct;36(10):1475-1486. doi: 10.1002/stem.2860. Epub 2018 Jul 31. Review.

17.

The multifaceted roles of perlecan in fibrosis.

Lord MS, Tang F, Rnjak-Kovacina J, Smith JGW, Melrose J, Whitelock JM.

Matrix Biol. 2018 Aug;68-69:150-166. doi: 10.1016/j.matbio.2018.02.013. Epub 2018 Feb 20. Review.

PMID:
29475023
18.

The adolescent idiopathic scoliotic IVD displays advanced aggrecanolysis and a glycosaminoglycan composition similar to that of aged human and ovine IVDs.

Shu CC, Melrose J.

Eur Spine J. 2018 Sep;27(9):2102-2113. doi: 10.1007/s00586-018-5515-2. Epub 2018 Feb 13.

PMID:
29441417
19.

Biodiversity of CS-proteoglycan sulphation motifs: chemical messenger recognition modules with roles in information transfer, control of cellular behaviour and tissue morphogenesis.

Hayes A, Sugahara K, Farrugia B, Whitelock JM, Caterson B, Melrose J.

Biochem J. 2018 Feb 9;475(3):587-620. doi: 10.1042/BCJ20170820. Review.

PMID:
29439148
20.

Keratan sulfate, a complex glycosaminoglycan with unique functional capability.

Caterson B, Melrose J.

Glycobiology. 2018 Apr 1;28(4):182-206. doi: 10.1093/glycob/cwy003. Review.

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