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Items: 1 to 20 of 28

1.

HIV-1 Integrase-Targeted Short Peptides Derived from a Viral Protein R Sequence.

Zhao XZ, Métifiot M, Kiselev E, Kessl JJ, Maddali K, Marchand C, Kvaratskhelia M, Pommier Y, Burke TR Jr.

Molecules. 2018 Jul 26;23(8). pii: E1858. doi: 10.3390/molecules23081858.

2.

A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain.

Patel D, Antwi J, Koneru PC, Serrao E, Forli S, Kessl JJ, Feng L, Deng N, Levy RM, Fuchs JR, Olson AJ, Engelman AN, Bauman JD, Kvaratskhelia M, Arnold E.

J Biol Chem. 2016 Nov 4;291(45):23569-23577. Epub 2016 Sep 19.

3.

Indole-based allosteric inhibitors of HIV-1 integrase.

Patel PA, Kvaratskhelia N, Mansour Y, Antwi J, Feng L, Koneru P, Kobe MJ, Jena N, Shi G, Mohamed MS, Li C, Kessl JJ, Fuchs JR.

Bioorg Med Chem Lett. 2016 Oct 1;26(19):4748-4752. doi: 10.1016/j.bmcl.2016.08.037. Epub 2016 Aug 13.

4.

HIV-1 Integrase Binds the Viral RNA Genome and Is Essential during Virion Morphogenesis.

Kessl JJ, Kutluay SB, Townsend D, Rebensburg S, Slaughter A, Larue RC, Shkriabai N, Bakouche N, Fuchs JR, Bieniasz PD, Kvaratskhelia M.

Cell. 2016 Aug 25;166(5):1257-1268.e12. doi: 10.1016/j.cell.2016.07.044.

5.

The Competitive Interplay between Allosteric HIV-1 Integrase Inhibitor BI/D and LEDGF/p75 during the Early Stage of HIV-1 Replication Adversely Affects Inhibitor Potency.

Feng L, Dharmarajan V, Serrao E, Hoyte A, Larue RC, Slaughter A, Sharma A, Plumb MR, Kessl JJ, Fuchs JR, Bushman FD, Engelman AN, Griffin PR, Kvaratskhelia M.

ACS Chem Biol. 2016 May 20;11(5):1313-21. doi: 10.1021/acschembio.6b00167. Epub 2016 Mar 2.

6.

Methods for the Analyses of Inhibitor-Induced Aberrant Multimerization of HIV-1 Integrase.

Kessl JJ, Sharma A, Kvaratskhelia M.

Methods Mol Biol. 2016;1354:149-64. doi: 10.1007/978-1-4939-3046-3_10.

7.

HIV-1 integrase multimerization as a therapeutic target.

Feng L, Larue RC, Slaughter A, Kessl JJ, Kvaratskhelia M.

Curr Top Microbiol Immunol. 2015;389:93-119. doi: 10.1007/82_2015_439. Review.

8.

The mechanism of H171T resistance reveals the importance of Nδ-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase.

Slaughter A, Jurado KA, Deng N, Feng L, Kessl JJ, Shkriabai N, Larue RC, Fadel HJ, Patel PA, Jena N, Fuchs JR, Poeschla E, Levy RM, Engelman A, Kvaratskhelia M.

Retrovirology. 2014 Nov 25;11:100. doi: 10.1186/s12977-014-0100-1.

9.

A critical role of the C-terminal segment for allosteric inhibitor-induced aberrant multimerization of HIV-1 integrase.

Shkriabai N, Dharmarajan V, Slaughter A, Kessl JJ, Larue RC, Feng L, Fuchs JR, Griffin PR, Kvaratskhelia M.

J Biol Chem. 2014 Sep 19;289(38):26430-40. doi: 10.1074/jbc.M114.589572. Epub 2014 Aug 12.

10.

A new class of multimerization selective inhibitors of HIV-1 integrase.

Sharma A, Slaughter A, Jena N, Feng L, Kessl JJ, Fadel HJ, Malani N, Male F, Wu L, Poeschla E, Bushman FD, Fuchs JR, Kvaratskhelia M.

PLoS Pathog. 2014 May 29;10(5):e1004171. doi: 10.1371/journal.ppat.1004171. eCollection 2014 May.

11.

BET proteins promote efficient murine leukemia virus integration at transcription start sites.

Sharma A, Larue RC, Plumb MR, Malani N, Male F, Slaughter A, Kessl JJ, Shkriabai N, Coward E, Aiyer SS, Green PL, Wu L, Roth MJ, Bushman FD, Kvaratskhelia M.

Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):12036-41. doi: 10.1073/pnas.1307157110. Epub 2013 Jul 1.

12.

Allosteric inhibition of HIV-1 integrase activity.

Engelman A, Kessl JJ, Kvaratskhelia M.

Curr Opin Chem Biol. 2013 Jun;17(3):339-45. doi: 10.1016/j.cbpa.2013.04.010. Epub 2013 May 3. Review.

13.

The A128T resistance mutation reveals aberrant protein multimerization as the primary mechanism of action of allosteric HIV-1 integrase inhibitors.

Feng L, Sharma A, Slaughter A, Jena N, Koh Y, Shkriabai N, Larue RC, Patel PA, Mitsuya H, Kessl JJ, Engelman A, Fuchs JR, Kvaratskhelia M.

J Biol Chem. 2013 May 31;288(22):15813-20. doi: 10.1074/jbc.M112.443390. Epub 2013 Apr 24.

14.

Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation.

Jurado KA, Wang H, Slaughter A, Feng L, Kessl JJ, Koh Y, Wang W, Ballandras-Colas A, Patel PA, Fuchs JR, Kvaratskhelia M, Engelman A.

Proc Natl Acad Sci U S A. 2013 May 21;110(21):8690-5. doi: 10.1073/pnas.1300703110. Epub 2013 Apr 22.

15.

Interaction of the HIV-1 intasome with transportin 3 protein (TNPO3 or TRN-SR2).

Larue R, Gupta K, Wuensch C, Shkriabai N, Kessl JJ, Danhart E, Feng L, Taltynov O, Christ F, Van Duyne GD, Debyser Z, Foster MP, Kvaratskhelia M.

J Biol Chem. 2012 Oct 5;287(41):34044-58. doi: 10.1074/jbc.M112.384669. Epub 2012 Aug 7.

16.

Multimode, cooperative mechanism of action of allosteric HIV-1 integrase inhibitors.

Kessl JJ, Jena N, Koh Y, Taskent-Sezgin H, Slaughter A, Feng L, de Silva S, Wu L, Le Grice SF, Engelman A, Fuchs JR, Kvaratskhelia M.

J Biol Chem. 2012 May 11;287(20):16801-11. doi: 10.1074/jbc.M112.354373. Epub 2012 Mar 21.

17.

FRET analysis reveals distinct conformations of IN tetramers in the presence of viral DNA or LEDGF/p75.

Kessl JJ, Li M, Ignatov M, Shkriabai N, Eidahl JO, Feng L, Musier-Forsyth K, Craigie R, Kvaratskhelia M.

Nucleic Acids Res. 2011 Nov 1;39(20):9009-22. doi: 10.1093/nar/gkr581. Epub 2011 Jul 19.

18.

HIV-1 Integrase-DNA Recognition Mechanisms.

Kessl JJ, McKee CJ, Eidahl JO, Shkriabai N, Katz A, Kvaratskhelia M.

Viruses. 2009 Dec;1(3):713-36. doi: 10.3390/v1030713. Epub 2009 Nov 5.

19.

An allosteric mechanism for inhibiting HIV-1 integrase with a small molecule.

Kessl JJ, Eidahl JO, Shkriabai N, Zhao Z, McKee CJ, Hess S, Burke TR Jr, Kvaratskhelia M.

Mol Pharmacol. 2009 Oct;76(4):824-32. doi: 10.1124/mol.109.058883. Epub 2009 Jul 28.

20.

Mass spectrometry-based footprinting of protein-protein interactions.

McKee CJ, Kessl JJ, Norris JO, Shkriabai N, Kvaratskhelia M.

Methods. 2009 Apr;47(4):304-7. doi: 10.1016/j.ymeth.2008.10.023. Epub 2008 Nov 17.

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