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Items: 1 to 20 of 90


N1-Propargylguanosine Modified mRNA Cap Analogs: Synthesis, Reactivity, and Applications to the Study of Cap-Binding Proteins.

Kopcial M, Wojtczak BA, Kasprzyk R, Kowalska J, Jemielity J.

Molecules. 2019 May 17;24(10). pii: E1899. doi: 10.3390/molecules24101899.


Fluorescent Turn-On Probes for the Development of Binding and Hydrolytic Activity Assays for mRNA Cap-Recognizing Proteins.

Kasprzyk R, Starek BJ, Ciechanowicz S, Kubacka D, Kowalska J, Jemielity J.

Chemistry. 2019 May 10;25(27):6728-6740. doi: 10.1002/chem.201900051. Epub 2019 Apr 1.


Nicotinamide-Containing Di- and Trinucleotides as Chemical Tools for Studies of NAD-Capped RNAs.

Mlynarska-Cieslak A, Depaix A, Grudzien-Nogalska E, Sikorski PJ, Warminski M, Kiledjian M, Jemielity J, Kowalska J.

Org Lett. 2018 Dec 7;20(23):7650-7655. doi: 10.1021/acs.orglett.8b03386. Epub 2018 Nov 27.


mRNAs biotinylated within the 5' cap and protected against decapping: new tools to capture RNA-protein complexes.

Bednarek S, Madan V, Sikorski PJ, Bartenschlager R, Kowalska J, Jemielity J.

Philos Trans R Soc Lond B Biol Sci. 2018 Nov 5;373(1762). pii: 20180167. doi: 10.1098/rstb.2018.0167.


Roquin targets mRNAs in a 3'-UTR-specific manner by different modes of regulation.

Essig K, Kronbeck N, Guimaraes JC, Lohs C, Schlundt A, Hoffmann A, Behrens G, Brenner S, Kowalska J, Lopez-Rodriguez C, Jemielity J, Holtmann H, Reiche K, Hackermüller J, Sattler M, Zavolan M, Heissmeyer V.

Nat Commun. 2018 Sep 19;9(1):3810. doi: 10.1038/s41467-018-06184-3.


Exploring the potential of phosphotriazole 5' mRNA cap analogues as efficient translation initiators.

Walczak S, Sikorski PJ, Kasprzyk R, Kowalska J, Jemielity J.

Org Biomol Chem. 2018 Sep 19;16(36):6741-6748. doi: 10.1039/c8ob01720d.


ExciTides: NTP-derived probes for monitoring pyrophosphatase activity based on excimer-to-monomer transitions.

Wanat P, Kasprzyk R, Kopcial M, Sikorski PJ, Strzelecka D, Jemielity J, Kowalska J.

Chem Commun (Camb). 2018 Aug 28;54(70):9773-9776. doi: 10.1039/c8cc04968h.


5'-Phosphorothiolate Dinucleotide Cap Analogues: Reagents for Messenger RNA Modification and Potent Small-Molecular Inhibitors of Decapping Enzymes.

Wojtczak BA, Sikorski PJ, Fac-Dabrowska K, Nowicka A, Warminski M, Kubacka D, Nowak E, Nowotny M, Kowalska J, Jemielity J.

J Am Chem Soc. 2018 May 9;140(18):5987-5999. doi: 10.1021/jacs.8b02597. Epub 2018 May 1.


Structure of the activated Edc1-Dcp1-Dcp2-Edc3 mRNA decapping complex with substrate analog poised for catalysis.

Mugridge JS, Tibble RW, Ziemniak M, Jemielity J, Gross JD.

Nat Commun. 2018 Mar 20;9(1):1152. doi: 10.1038/s41467-018-03536-x.


Azido-Functionalized 5' Cap Analogues for the Preparation of Translationally Active mRNAs Suitable for Fluorescent Labeling in Living Cells.

Mamot A, Sikorski PJ, Warminski M, Kowalska J, Jemielity J.

Angew Chem Int Ed Engl. 2017 Dec 4;56(49):15628-15632. doi: 10.1002/anie.201709052. Epub 2017 Nov 7.


Analysis of mononucleotides by tandem mass spectrometry: investigation of fragmentation pathways for phosphate- and ribose-modified nucleotide analogues.

Strzelecka D, Chmielinski S, Bednarek S, Jemielity J, Kowalska J.

Sci Rep. 2017 Aug 21;7(1):8931. doi: 10.1038/s41598-017-09416-6.


mRNA cap analogues substituted in the tetraphosphate chain with CX2: identification of O-to-CCl2 as the first bridging modification that confers resistance to decapping without impairing translation.

Rydzik AM, Warminski M, Sikorski PJ, Baranowski MR, Walczak S, Kowalska J, Zuberek J, Lukaszewicz M, Nowak E, W Claridge TD, Darzynkiewicz E, Nowotny M, Jemielity J.

Nucleic Acids Res. 2017 Sep 6;45(15):8661-8675. doi: 10.1093/nar/gkx569.


Synthesis of RNA 5'-Azides from 2'-O-Pivaloyloxymethyl-Protected RNAs and Their Reactivity in Azide-Alkyne Cycloaddition Reactions.

Warminski M, Kowalska J, Jemielity J.

Org Lett. 2017 Jul 7;19(13):3624-3627. doi: 10.1021/acs.orglett.7b01591. Epub 2017 Jun 21.


Amino-Functionalized 5' Cap Analogs as Tools for Site-Specific Sequence-Independent Labeling of mRNA.

Warminski M, Sikorski PJ, Warminska Z, Lukaszewicz M, Kropiwnicka A, Zuberek J, Darzynkiewicz E, Kowalska J, Jemielity J.

Bioconjug Chem. 2017 Jul 19;28(7):1978-1992. doi: 10.1021/acs.bioconjchem.7b00291. Epub 2017 Jun 27.


eIF4E phosphorylation by MST1 reduces translation of a subset of mRNAs, but increases lncRNA translation.

Min KW, Davila S, Zealy RW, Lloyd LT, Lee IY, Lee R, Roh KH, Jung A, Jemielity J, Choi EJ, Chang JH, Yoon JH.

Biochim Biophys Acta Gene Regul Mech. 2017 Jul;1860(7):761-772. doi: 10.1016/j.bbagrm.2017.05.002. Epub 2017 May 6.


A novel route for preparing 5' cap mimics and capped RNAs: phosphate-modified cap analogues obtained via click chemistry.

Walczak S, Nowicka A, Kubacka D, Fac K, Wanat P, Mroczek S, Kowalska J, Jemielity J.

Chem Sci. 2017 Jan 1;8(1):260-267. doi: 10.1039/c6sc02437h. Epub 2016 Aug 16.


Central Regulatory Role for SIN1 in Interferon γ (IFNγ) Signaling and Generation of Biological Responses.

Kroczynska B, Blyth GT, Rafidi RL, Majchrzak-Kita B, Xu L, Saleiro D, Kosciuczuk EM, Jemielity J, Su B, Altman JK, Eklund EA, Fish EN, Platanias LC.

J Biol Chem. 2017 Mar 17;292(11):4743-4752. doi: 10.1074/jbc.M116.757666. Epub 2017 Feb 7.


Applications of Phosphate Modification and Labeling to Study (m)RNA Caps.

Warminski M, Sikorski PJ, Kowalska J, Jemielity J.

Top Curr Chem (Cham). 2017 Feb;375(1):16. doi: 10.1007/s41061-017-0106-y. Epub 2017 Jan 23. Review.


Cap analogs modified with 1,2-dithiodiphosphate moiety protect mRNA from decapping and enhance its translational potential.

Strenkowska M, Grzela R, Majewski M, Wnek K, Kowalska J, Lukaszewicz M, Zuberek J, Darzynkiewicz E, Kuhn AN, Sahin U, Jemielity J.

Nucleic Acids Res. 2016 Nov 16;44(20):9578-9590. Epub 2016 Oct 7.


Structural basis of mRNA-cap recognition by Dcp1-Dcp2.

Mugridge JS, Ziemniak M, Jemielity J, Gross JD.

Nat Struct Mol Biol. 2016 Nov;23(11):987-994. doi: 10.1038/nsmb.3301. Epub 2016 Oct 3.

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