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Items: 1 to 20 of 131


Discovery of a Cryptic Intermediate in Late Steps of Mithramycin Biosynthesis.

Wheeler R, Yu X, Hou C, Mitra P, Chen JM, Herkules F, Ivanov DN, Tsodikov OV, Rohr J.

Angew Chem Int Ed Engl. 2020 Jan 7;59(2):826-832. doi: 10.1002/anie.201910241. Epub 2019 Nov 27.


Dihydroisocoumarins produced by Diaporthe cf. heveae LGMF1631 inhibiting citrus pathogens.

Savi DC, Noriler SA, Ponomareva LV, Thorson JS, Rohr J, Glienke C, Shaaban KA.

Folia Microbiol (Praha). 2019 Aug 10. doi: 10.1007/s12223-019-00746-8. [Epub ahead of print]


Vochysiamides A and B: Two new bioactive carboxamides produced by the new species Diaporthe vochysiae.

Noriler SA, Savi DC, Ponomareva LV, Rodrigues R, Rohr J, Thorson JS, Glienke C, Shaaban KA.

Fitoterapia. 2019 Oct;138:104273. doi: 10.1016/j.fitote.2019.104273. Epub 2019 Jul 22.


How mithramycin stereochemistry dictates its structure and DNA binding function.

Hou C, Rohr J, Parkin S, Tsodikov OV.

Medchemcomm. 2019 Mar 28;10(5):735-741. doi: 10.1039/c9md00100j. eCollection 2019 May 1.


Bioanalytical method for quantitative determination of mithramycin analogs in mouse plasma by HPLC-QTOF.

Eckenrode JM, Mitra P, Rohr J, Leggas M.

Biomed Chromatogr. 2019 Aug;33(8):e4544. doi: 10.1002/bmc.4544. Epub 2019 May 10.


Secondary metabolites produced by the citrus phytopathogen Phyllosticta citricarpa.

Savi DC, Shaaban KA, Mitra P, Ponomareva LV, Thorson JS, Glienke C, Rohr J.

J Antibiot (Tokyo). 2019 May;72(5):306-310. doi: 10.1038/s41429-019-0154-3. Epub 2019 Feb 21.


Secondary metabolites produced by Microbacterium sp. LGMB471 with antifungal activity against the phytopathogen Phyllosticta citricarpa.

Savi DC, Shaaban KA, Gos FMW, Thorson JS, Glienke C, Rohr J.

Folia Microbiol (Praha). 2019 May;64(3):453-460. doi: 10.1007/s12223-018-00668-x. Epub 2018 Dec 18.


Development of Mithramycin Analogues with Increased Selectivity toward ETS Transcription Factor Expressing Cancers.

Mitra P, Eckenrode JM, Mandal A, Jha AK, Salem SM, Leggas M, Rohr J.

J Med Chem. 2018 Sep 13;61(17):8001-8016. doi: 10.1021/acs.jmedchem.8b01107. Epub 2018 Aug 28.


Self-Resistance during Muraymycin Biosynthesis: a Complementary Nucleotidyltransferase and Phosphotransferase with Identical Modification Sites and Distinct Temporal Order.

Cui Z, Wang XC, Liu X, Lemke A, Koppermann S, Ducho C, Rohr J, Thorson JS, Van Lanen SG.

Antimicrob Agents Chemother. 2018 Jun 26;62(7). pii: e00193-18. doi: 10.1128/AAC.00193-18. Print 2018 Jul.


Bioprospecting of Diaporthe terebinthifolii LGMF907 for antimicrobial compounds.

de Medeiros AG, Savi DC, Mitra P, Shaaban KA, Jha AK, Thorson JS, Rohr J, Glienke C.

Folia Microbiol (Praha). 2018 Jul;63(4):499-505. doi: 10.1007/s12223-018-0587-2. Epub 2018 Mar 1.


Phaeophleospora vochysiae Savi & Glienke sp. nov. Isolated from Vochysia divergens Found in the Pantanal, Brazil, Produces Bioactive Secondary Metabolites.

Savi DC, Shaaban KA, Gos FMWR, Ponomareva LV, Thorson JS, Glienke C, Rohr J.

Sci Rep. 2018 Feb 15;8(1):3122. doi: 10.1038/s41598-018-21400-2.


Structural Basis for EarP-Mediated Arginine Glycosylation of Translation Elongation Factor EF-P.

Krafczyk R, Macošek J, Jagtap PKA, Gast D, Wunder S, Mitra P, Jha AK, Rohr J, Hoffmann-Röder A, Jung K, Hennig J, Lassak J.

mBio. 2017 Sep 26;8(5). pii: e01412-17. doi: 10.1128/mBio.01412-17.


Antibacterial Activity of Endophytic Actinomycetes Isolated from the Medicinal Plant Vochysia divergens (Pantanal, Brazil).

Gos FMWR, Savi DC, Shaaban KA, Thorson JS, Aluizio R, Possiede YM, Rohr J, Glienke C.

Front Microbiol. 2017 Sep 6;8:1642. doi: 10.3389/fmicb.2017.01642. eCollection 2017.


Two Cooperative Glycosyltransferases Are Responsible for the Sugar Diversity of Saquayamycins Isolated from Streptomyces sp. KY 40-1.

Salem SM, Weidenbach S, Rohr J.

ACS Chem Biol. 2017 Oct 20;12(10):2529-2534. doi: 10.1021/acschembio.7b00453. Epub 2017 Sep 13.


Formation of an Angular Aromatic Polyketide from a Linear Anthrene Precursor via Oxidative Rearrangement.

Gao G, Liu X, Xu M, Wang Y, Zhang F, Xu L, Lv J, Long Q, Kang Q, Ou HY, Wang Y, Rohr J, Deng Z, Jiang M, Lin S, Tao M.

Cell Chem Biol. 2017 Jul 20;24(7):881-891.e4. doi: 10.1016/j.chembiol.2017.06.008. Epub 2017 Jul 14.


Bi- and Tetracyclic Spirotetronates from the Coal Mine Fire Isolate Streptomyces sp. LC-6-2.

Wang X, Elshahawi SI, Cai W, Zhang Y, Ponomareva LV, Chen X, Copley GC, Hower JC, Zhan CG, Parkin S, Rohr J, Van Lanen SG, Shaaban KA, Thorson JS.

J Nat Prod. 2017 Apr 28;80(4):1141-1149. doi: 10.1021/acs.jnatprod.7b00108. Epub 2017 Mar 30.


Rapid generation of hydrogen peroxide contributes to the complex cell death induction by the angucycline antibiotic landomycin E.

Panchuk RR, Lehka LV, Terenzi A, Matselyukh BP, Rohr J, Jha AK, Downey T, Kril IJ, Herbacek I, van Schoonhoven S, Heffeter P, Stoika RS, Berger W.

Free Radic Biol Med. 2017 May;106:134-147. doi: 10.1016/j.freeradbiomed.2017.02.024. Epub 2017 Feb 9.


One-Pot Enzymatic Total Synthesis of Presteffimycinone, an Early Intermediate of the Anthracycline Antibiotic Steffimycin Biosynthesis.

Wang G, Chen J, Zhu H, Rohr J.

Org Lett. 2017 Feb 3;19(3):540-543. doi: 10.1021/acs.orglett.6b03708. Epub 2017 Jan 19.


Evidence that oxidative dephosphorylation by the nonheme Fe(II), α-ketoglutarate:UMP oxygenase occurs by stereospecific hydroxylation.

Goswami A, Liu X, Cai W, Wyche TP, Bugni TS, Meurillon M, Peyrottes S, Perigaud C, Nonaka K, Rohr J, Van Lanen SG.

FEBS Lett. 2017 Feb;591(3):468-478. doi: 10.1002/1873-3468.12554. Epub 2017 Jan 25.


Disruption of de Novo Adenosine Triphosphate (ATP) Biosynthesis Abolishes Virulence in Cryptococcus neoformans.

Blundell RD, Williams SJ, Arras SD, Chitty JL, Blake KL, Ericsson DJ, Tibrewal N, Rohr J, Koh YQ, Kappler U, Robertson AA, Butler MS, Cooper MA, Kobe B, Fraser JA.

ACS Infect Dis. 2016 Sep 9;2(9):651-663. Epub 2016 Aug 17.


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