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Items: 1 to 20 of 143


The potential of dopamine receptor D2 (DRD2) as a therapeutic target for tackling pancreatic cancer.

Bakadlag R, Jandaghi P, Hoheisel JD, Riazalhosseini Y.

Expert Opin Ther Targets. 2019 May;23(5):365-367. doi: 10.1080/14728222.2019.1606904. Epub 2019 Apr 26. No abstract available.


Impact of the secretome of activated pancreatic stellate cells on growth and differentiation of pancreatic tumour cells.

Marzoq AJ, Mustafa SA, Heidrich L, Hoheisel JD, Alhamdani MSS.

Sci Rep. 2019 Mar 28;9(1):5303. doi: 10.1038/s41598-019-41740-x.


Copying Life: Synthesis of an Enzymatically Active Mirror-Image DNA-Ligase Made of D-Amino Acids.

Weidmann J, Schnölzer M, Dawson PE, Hoheisel JD.

Cell Chem Biol. 2019 May 16;26(5):645-651.e3. doi: 10.1016/j.chembiol.2019.02.008. Epub 2019 Mar 14.


N⁶-Methyladenosine Landscape of Glioma Stem-Like Cells: METTL3 Is Essential for the Expression of Actively Transcribed Genes and Sustenance of the Oncogenic Signaling.

Visvanathan A, Patil V, Abdulla S, Hoheisel JD, Somasundaram K.

Genes (Basel). 2019 Feb 13;10(2). pii: E141. doi: 10.3390/genes10020141.


GHSR DNA hypermethylation is a new epigenetic biomarker for gastric adenocarcinoma and beyond.

Amini M, Foroughi K, Talebi F, Aghagolzade Haji H, Kamali F, Jandaghi P, Hoheisel JD, Manoochehri M.

J Cell Physiol. 2019 Jan 24. doi: 10.1002/jcp.28179. [Epub ahead of print]


Function, clinical application, and strategies of Pre-mRNA splicing in cancer.

Di C, Syafrizayanti, Zhang Q, Chen Y, Wang Y, Zhang X, Liu Y, Sun C, Zhang H, Hoheisel JD.

Cell Death Differ. 2019 Jul;26(7):1181-1194. doi: 10.1038/s41418-018-0231-3. Epub 2018 Nov 21.


Long noncoding RNA HOTAIR is upregulated in an aggressive subgroup of gastrointestinal stromal tumors (GIST) and mediates the establishment of gene-specific DNA methylation patterns.

Bure I, Geer S, Knopf J, Roas M, Henze S, Ströbel P, Agaimy A, Wiemann S, Hoheisel JD, Hartmann A, Haller F, Moskalev EA.

Genes Chromosomes Cancer. 2018 Nov;57(11):584-597. doi: 10.1002/gcc.22672. Epub 2018 Sep 24.


Long intergenic noncoding RNA 299 methylation in peripheral blood is a biomarker for triple-negative breast cancer.

Bermejo JL, Huang G, Manoochehri M, Mesa KG, Schick M, Silos RG, Ko YD, Brüning T, Brauch H, Lo WY, Hoheisel JD, Hamann U.

Epigenomics. 2019 Jan;11(1):81-93. doi: 10.2217/epi-2018-0121. Epub 2018 Sep 13.


The structural basis of nanobody unfolding reversibility and thermoresistance.

Kunz P, Zinner K, Mücke N, Bartoschik T, Muyldermans S, Hoheisel JD.

Sci Rep. 2018 May 21;8(1):7934. doi: 10.1038/s41598-018-26338-z.


Immunoprofiling of Chlamydia trachomatis using whole-proteome microarrays generated by on-chip in situ expression.

Hufnagel K, Lueong S, Willhauck-Fleckenstein M, Hotz-Wagenblatt A, Miao B, Bauer A, Michel A, Butt J, Pawlita M, Hoheisel JD, Waterboer T.

Sci Rep. 2018 May 14;8(1):7503. doi: 10.1038/s41598-018-25918-3.


Molecular signatures associated with tumor-specific immune response in melanoma patients treated with dendritic cell-based immunotherapy.

García-Salum T, Villablanca A, Matthäus F, Tittarelli A, Baeza M, Pereda C, Gleisner MA, González FE, López MN, Hoheisel JD, Norgauer J, Gebicke-Haerter PJ, Salazar-Onfray F.

Oncotarget. 2018 Mar 30;9(24):17014-17027. doi: 10.18632/oncotarget.24795. eCollection 2018 Mar 30.


The deubiquitinating enzyme USP5 promotes pancreatic cancer via modulating cell cycle regulators.

Kaistha BP, Krattenmacher A, Fredebohm J, Schmidt H, Behrens D, Widder M, Hackert T, Strobel O, Hoheisel JD, Gress TM, Buchholz M.

Oncotarget. 2017 Aug 3;8(39):66215-66225. doi: 10.18632/oncotarget.19882. eCollection 2017 Sep 12.


Transcriptional variations in the wider peritumoral tissue environment of pancreatic cancer.

Bauer AS, Nazarov PV, Giese NA, Beghelli S, Heller A, Greenhalf W, Costello E, Muller A, Bier M, Strobel O, Hackert T, Vallar L, Scarpa A, Büchler MW, Neoptolemos JP, Kreis S, Hoheisel JD.

Int J Cancer. 2018 Mar 1;142(5):1010-1021. doi: 10.1002/ijc.31087. Epub 2017 Oct 17.


Exploiting sequence and stability information for directing nanobody stability engineering.

Kunz P, Flock T, Soler N, Zaiss M, Vincke C, Sterckx Y, Kastelic D, Muyldermans S, Hoheisel JD.

Biochim Biophys Acta Gen Subj. 2017 Sep;1861(9):2196-2205. doi: 10.1016/j.bbagen.2017.06.014. Epub 2017 Jun 20.


Comparison of the tumor cell secretome and patient sera for an accurate serum-based diagnosis of pancreatic ductal adenocarcinoma.

Mustafa S, Pan L, Marzoq A, Fawaz M, Sander L, Rückert F, Schrenk A, Hartl C, Uhler R, Yildirim A, Strobel O, Hackert T, Giese N, Büchler MW, Hoheisel JD, Alhamdani MS.

Oncotarget. 2017 Feb 14;8(7):11963-11976. doi: 10.18632/oncotarget.14449.


Personalised proteome analysis by means of protein microarrays made from individual patient samples.

Syafrizayanti, Lueong SS, Di C, Schaefer JV, Plückthun A, Hoheisel JD.

Sci Rep. 2017 Jan 3;7:39756. doi: 10.1038/srep39756.


Expression of DRD2 Is Increased in Human Pancreatic Ductal Adenocarcinoma and Inhibitors Slow Tumor Growth in Mice.

Jandaghi P, Najafabadi HS, Bauer AS, Papadakis AI, Fassan M, Hall A, Monast A, von Knebel Doeberitz M, Neoptolemos JP, Costello E, Greenhalf W, Scarpa A, Sipos B, Auld D, Lathrop M, Park M, Büchler MW, Strobel O, Hackert T, Giese NA, Zogopoulos G, Sangwan V, Huang S, Riazalhosseini Y, Hoheisel JD.

Gastroenterology. 2016 Dec;151(6):1218-1231. doi: 10.1053/j.gastro.2016.08.040. Epub 2016 Aug 28.


CRISPR RNA-guided FokI nucleases repair a PAH variant in a phenylketonuria model.

Pan Y, Shen N, Jung-Klawitter S, Betzen C, Hoffmann GF, Hoheisel JD, Blau N.

Sci Rep. 2016 Oct 27;6:35794. doi: 10.1038/srep35794.


Secretome profiling of apheresis platelet supernatants during routine storage via antibody-based microarray.

Kamhieh-Milz J, Mustafa SA, Sterzer V, Celik H, Keski S, Khorramshahi O, Movassaghi K, Hoheisel JD, Alhamdani MS, Salama A.

J Proteomics. 2017 Jan 6;150:74-85. doi: 10.1016/j.jprot.2016.07.028. Epub 2016 Jul 28.


Protein Profiling Gastric Cancer and Neighboring Control Tissues Using High-Content Antibody Microarrays.

Sill M, Schröder C, Shen Y, Marzoq A, Komel R, Hoheisel JD, Nienhüser H, Schmidt T, Kastelic D.

Microarrays (Basel). 2016 Jul 8;5(3). pii: E19. doi: 10.3390/microarrays5030019.

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