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Items: 1 to 20 of 65

1.

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-5.

Mangoni AA, Eynde JJV, Jampilek J, Hadjipavlou-Litina D, Liu H, Reynisson J, Sousa ME, Gomes PAC, Prokai-Tatrai K, Tuccinardi T, Sabatier JM, Luque FJ, Rautio J, Karaman R, Vasconcelos MH, Gemma S, Galdiero S, Hulme C, Collina S, Gütschow M, Kokotos G, Siciliano C, Capasso R, Agrofoglio LA, Ragno R, Muñoz-Torrero D.

Molecules. 2019 Jun 30;24(13). pii: E2415. doi: 10.3390/molecules24132415.

2.

Antifungal screening and in silico mechanistic studies of an in-house azole library.

Sari S, Kart D, Sabuncuoğlu S, Doğan İS, Özdemir Z, Bozbey İ, Gencel M, Eşsiz Ş, Reynisson J, Karakurt A, Saraç S, Dalkara S.

Chem Biol Drug Des. 2019 Jul 1. doi: 10.1111/cbdd.13587. [Epub ahead of print]

PMID:
31260179
3.

Generation of Quality Hit Matter for Successful Drug Discovery Projects.

Reynisson J.

Molecules. 2019 Jan 22;24(3). pii: E381. doi: 10.3390/molecules24030381.

4.

Novel Inhibitors of DNA Repair Enzyme TDP1 Combining Monoterpenoid and Adamantane Fragments.

Mozhaitsev ES, Zakharenko AL, Suslov EV, Korchagina DV, Zakharova OD, Vasil'eva IA, Chepanova AA, Black E, Patel J, Chand R, Reynisson J, Leung IKH, Volcho KP, Salakhutdinov NF, Lavrik OI.

Anticancer Agents Med Chem. 2019;19(4):463-472. doi: 10.2174/1871520619666181207094243.

PMID:
30523770
5.

New Water-Soluble Copper(II) Complexes with Morpholine-Thiosemicarbazone Hybrids: Insights into the Anticancer and Antibacterial Mode of Action.

Ohui K, Afanasenko E, Bacher F, Ting RLX, Zafar A, Blanco-Cabra N, Torrents E, Dömötör O, May NV, Darvasiova D, Enyedy ÉA, Popović-Bijelić A, Reynisson J, Rapta P, Babak MV, Pastorin G, Arion VB.

J Med Chem. 2019 Jan 24;62(2):512-530. doi: 10.1021/acs.jmedchem.8b01031. Epub 2018 Dec 18.

6.

From Catalysis to Cancer: Toward Structure-Activity Relationships for Benzimidazol-2-ylidene-Derived N-Heterocyclic-Carbene Complexes as Anticancer Agents.

Lam NYS, Truong D, Burmeister H, Babak MV, Holtkamp HU, Movassaghi S, Ayine-Tora DM, Zafar A, Kubanik M, Oehninger L, Söhnel T, Reynisson J, Jamieson SMF, Gaiddon C, Ott I, Hartinger CG.

Inorg Chem. 2018 Nov 19;57(22):14427-14434. doi: 10.1021/acs.inorgchem.8b02634. Epub 2018 Nov 8.

PMID:
30406647
7.

The Development of a Weighted Index to Optimise Compound Libraries for High Throughput Screening.

Eurtivong C, Reynisson J.

Mol Inform. 2019 Mar;38(3):e1800068. doi: 10.1002/minf.201800068. Epub 2018 Oct 22.

PMID:
30345657
8.

A Novel Class of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Contains the Octahydro-2H-chromen-4-ol Scaffold.

Li-Zhulanov NS, Zakharenko AL, Chepanova AA, Patel J, Zafar A, Volcho KP, Salakhutdinov NF, Reynisson J, Leung IKH, Lavrik OI.

Molecules. 2018 Sep 26;23(10). pii: E2468. doi: 10.3390/molecules23102468.

9.

A Chemometric Analysis of Compounds from Native New Zealand Medicinal Flora.

Pilkington LI, Yang X, Liu MW, Hemar Y, Brimble MA, Reynisson J.

Chem Asian J. 2019 Apr 15;14(8):1117-1127. doi: 10.1002/asia.201800803. Epub 2018 Sep 14.

PMID:
30125474
10.

Development of NMR and thermal shift assays for the evaluation of Mycobacterium tuberculosis isocitrate lyase inhibitors.

Bhusal RP, Patel K, Kwai BXC, Swartjes A, Bashiri G, Reynisson J, Sperry J, Leung IKH.

Medchemcomm. 2017 Oct 17;8(11):2155-2163. doi: 10.1039/c7md00456g. eCollection 2017 Nov 1.

11.

Synthesis and evaluation of aryliden- and hetarylidenfuranone derivatives of usnic acid as highly potent Tdp1 inhibitors.

Zakharova O, Luzina O, Zakharenko A, Sokolov D, Filimonov A, Dyrkheeva N, Chepanova A, Ilina E, Ilyina A, Klabenkova K, Chelobanov B, Stetsenko D, Zafar A, Eurtivong C, Reynisson J, Volcho K, Salakhutdinov N, Lavrik O.

Bioorg Med Chem. 2018 Aug 15;26(15):4470-4480. doi: 10.1016/j.bmc.2018.07.039. Epub 2018 Jul 24.

PMID:
30076000
12.

Novel Semisynthetic Derivatives of Bile Acids as Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibitors.

Salomatina OV, Popadyuk II, Zakharenko AL, Zakharova OD, Fadeev DS, Komarova NI, Reynisson J, Arabshahi HJ, Chand R, Volcho KP, Salakhutdinov NF, Lavrik OI.

Molecules. 2018 Mar 17;23(3). pii: E679. doi: 10.3390/molecules23030679.

13.

Investigation into Improving the Aqueous Solubility of the Thieno[2,3-b]pyridine Anti-Proliferative Agents.

Zafar A, Pilkington LI, Haverkate NA, van Rensburg M, Leung E, Kumara S, Denny WA, Barker D, Alsuraifi A, Hoskins C, Reynisson J.

Molecules. 2018 Jan 11;23(1). pii: E145. doi: 10.3390/molecules23010145.

14.

GPCR Modulation of Thieno[2,3-b]pyridine Anti-Proliferative Agents.

Zafar A, Sari S, Leung E, Pilkington LI, van Rensburg M, Barker D, Reynisson J.

Molecules. 2017 Dec 18;22(12). pii: E2254. doi: 10.3390/molecules22122254.

15.

Aminoadamantanes containing monoterpene-derived fragments as potent tyrosyl-DNA phosphodiesterase 1 inhibitors.

Ponomarev KY, Suslov EV, Zakharenko AL, Zakharova OD, Rogachev AD, Korchagina DV, Zafar A, Reynisson J, Nefedov AA, Volcho KP, Salakhutdinov NF, Lavrik OI.

Bioorg Chem. 2018 Feb;76:392-399. doi: 10.1016/j.bioorg.2017.12.005. Epub 2017 Dec 9.

PMID:
29248742
16.

Thieno[2,3-b]pyridine derivatives are potent anti-platelet drugs, inhibiting platelet activation, aggregation and showing synergy with aspirin.

Binsaleh NK, Wigley CA, Whitehead KA, van Rensburg M, Reynisson J, Pilkington LI, Barker D, Jones S, Dempsey-Hibbert NC.

Eur J Med Chem. 2018 Jan 1;143:1997-2004. doi: 10.1016/j.ejmech.2017.11.014. Epub 2017 Nov 7.

PMID:
29129512
17.

Synthesis and in vitro Biological Evaluation of Ferrocenyl Side-Chain-Functionalized Paclitaxel Derivatives.

Plażuk D, Wieczorek A, Ciszewski WM, Kowalczyk K, Błauż A, Pawlędzio S, Makal A, Eurtivong C, Arabshahi HJ, Reynisson J, Hartinger CG, Rychlik B.

ChemMedChem. 2017 Nov 22;12(22):1882-1892. doi: 10.1002/cmdc.201700576. Epub 2017 Nov 2.

PMID:
28941201
18.

Anti-influenza activity of diazaadamantanes combined with monoterpene moieties.

Suslov E, Zarubaev VV, Slita AV, Ponomarev K, Korchagina D, Ayine-Tora DM, Reynisson J, Volcho K, Salakhutdinov N.

Bioorg Med Chem Lett. 2017 Oct 1;27(19):4531-4535. doi: 10.1016/j.bmcl.2017.08.062. Epub 2017 Sep 1.

PMID:
28886889
19.

New Anti-Seizure (Arylalkyl)azole Derivatives: Synthesis, In Vivo and In Silico Studies.

Sari S, Dalkara S, Kaynak FB, Reynisson J, Saraç S, Karakurt A.

Arch Pharm (Weinheim). 2017 Jun;350(6). doi: 10.1002/ardp.201700043. Epub 2017 May 2.

PMID:
28464338
20.

Glycophenotype of breast and prostate cancer stem cells treated with thieno[2,3-b]pyridine anticancer compound.

Mastelić A, Čikeš Čulić V, Režić Mužinić N, Vuica-Ross M, Barker D, Leung EY, Reynisson J, Markotić A.

Drug Des Devel Ther. 2017 Mar 14;11:759-769. doi: 10.2147/DDDT.S121122. eCollection 2017.

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