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Items: 12

1.

The 3'-untranslated region contributes to the pregnane X receptor (PXR) expression down-regulation by PXR ligands and up-regulation by glucocorticoids.

Smutny T, Dusek J, Hyrsova L, Nekvindova J, Horvatova A, Micuda S, Gerbal-Chaloin S, Pavek P.

Acta Pharm Sin B. 2020 Jan;10(1):136-152. doi: 10.1016/j.apsb.2019.09.010. Epub 2019 Oct 21.

2.

Development of 3,5-Dinitrophenyl-Containing 1,2,4-Triazoles and Their Trifluoromethyl Analogues as Highly Efficient Antitubercular Agents Inhibiting Decaprenylphosphoryl-β-d-ribofuranose 2'-Oxidase.

Karabanovich G, Dušek J, Savková K, Pavliš O, Pávková I, Korábečný J, Kučera T, Kočová Vlčková H, Huszár S, Konyariková Z, Konečná K, Jand'ourek O, Stolaříková J, Korduláková J, Vávrová K, Pávek P, Klimešová V, Hrabálek A, Mikušová K, Roh J.

J Med Chem. 2019 Sep 12;62(17):8115-8139. doi: 10.1021/acs.jmedchem.9b00912. Epub 2019 Aug 22.

PMID:
31393122
3.

Stilbene compound trans-3,4,5,4´-tetramethoxystilbene, a potential anticancer drug, regulates constitutive androstane receptor (Car) target genes, but does not possess proliferative activity in mouse liver.

Dusek J, Skoda J, Holas O, Horvatova A, Smutny T, Linhartova L, Hirsova P, Kucera O, Micuda S, Braeuning A, Pavek P.

Toxicol Lett. 2019 Oct 1;313:1-10. doi: 10.1016/j.toxlet.2019.05.024. Epub 2019 Jun 4.

PMID:
31170421
4.

Trans-resveratrol, but not other natural stilbenes occurring in food, carries the risk of drug-food interaction via inhibition of cytochrome P450 enzymes or interaction with xenosensor receptors.

Hyrsova L, Vanduchova A, Dusek J, Smutny T, Carazo A, Maresova V, Trejtnar F, Barta P, Anzenbacher P, Dvorak Z, Pavek P.

Toxicol Lett. 2019 Jan;300:81-91. doi: 10.1016/j.toxlet.2018.10.028. Epub 2018 Oct 27.

PMID:
30394306
5.

Teriflunomide Is an Indirect Human Constitutive Androstane Receptor (CAR) Activator Interacting With Epidermal Growth Factor (EGF) Signaling.

Carazo A, Dusek J, Holas O, Skoda J, Hyrsova L, Smutny T, Soukup T, Dosedel M, Pávek P.

Front Pharmacol. 2018 Oct 11;9:993. doi: 10.3389/fphar.2018.00993. eCollection 2018.

6.

Effect of Endocannabinoid Oleamide on Rat and Human Liver Cytochrome P450 Enzymes in In Vitro and In Vivo Models.

Dovrtelova G, Zendulka O, Noskova K, Jurica J, Pes O, Dusek J, Carazo A, Zapletalova I, Hlavacova N, Pavek P.

Drug Metab Dispos. 2018 Jun;46(6):913-923. doi: 10.1124/dmd.117.079582. Epub 2018 Apr 12.

PMID:
29650790
7.

Steviol, an aglycone of steviol glycoside sweeteners, interacts with the pregnane X (PXR) and aryl hydrocarbon (AHR) receptors in detoxification regulation.

Dusek J, Carazo A, Trejtnar F, Hyrsova L, Holas O, Smutny T, Micuda S, Pavek P.

Food Chem Toxicol. 2017 Nov;109(Pt 1):130-142. doi: 10.1016/j.fct.2017.09.007. Epub 2017 Sep 5.

PMID:
28887089
8.

Synthesis and antiproteasomal activity of novel O-benzyl salicylamide-based inhibitors built from leucine and phenylalanine.

Jorda R, Dušek J, Řezníčková E, Pauk K, Magar PP, Imramovský A, Kryštof V.

Eur J Med Chem. 2017 Jul 28;135:142-158. doi: 10.1016/j.ejmech.2017.04.027. Epub 2017 Apr 15.

PMID:
28441582
9.

Acetylated deoxycholic (DCA) and cholic (CA) acids are potent ligands of pregnane X (PXR) receptor.

Carazo A, Hyrsova L, Dusek J, Chodounska H, Horvatova A, Berka K, Bazgier V, Gan-Schreier H, Chamulitrat W, Kudova E, Pavek P.

Toxicol Lett. 2017 Jan 4;265:86-96. doi: 10.1016/j.toxlet.2016.11.013. Epub 2016 Nov 18.

PMID:
27871908
10.

Synthesis of novel amphiphilic hyaluronan containing-aromatic fatty acids for fabrication of polymeric micelles.

Matelová A, Huerta-Angeles G, Šmejkalová D, Brůnová Z, Dušek J, Vícha R, Velebný V.

Carbohydr Polym. 2016 Oct 20;151:1175-1183. doi: 10.1016/j.carbpol.2016.06.085. Epub 2016 Jun 21.

PMID:
27474668
11.

Optical and Magneto-Optical Properties of Gd22Fe78 Thin Films in the Photon Energy Range From 1.5 to 5.5 eV.

Jesenská E, Hashinaka T, Ishibashi T, Beran L, Dušek J, Antoš R, Kuga K, Aoshima KI, Machida K, Kinjo H, Veis M.

Materials (Basel). 2016 Jan 2;9(1). pii: E23. doi: 10.3390/ma9010023.

12.

Substituted 2-hydroxy-N-(arylalkyl)benzamides induce apoptosis in cancer cell lines.

Imramovský A, Jorda R, Pauk K, Rezníčková E, Dušek J, Hanusek J, Kryštof V.

Eur J Med Chem. 2013 Oct;68:253-9. doi: 10.1016/j.ejmech.2013.08.009. Epub 2013 Aug 14.

PMID:
23981532

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