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Items: 1 to 20 of 41

1.

An approach to recombinantly produce mature grape polyphenol oxidase.

Li Y, McLarin MA, Middleditch MJ, Morrow SJ, Kilmartin PA, Leung IKH.

Biochimie. 2019 Jul 5;165:40-47. doi: 10.1016/j.biochi.2019.07.002. [Epub ahead of print]

PMID:
31283975
2.

An improved method for the heterologous production of soluble human ribosomal proteins in Escherichia coli.

Correddu D, Montaño López JJ, Vadakkedath PG, Lai A, Pernes JI, Watson PR, Leung IKH.

Sci Rep. 2019 Jun 20;9(1):8884. doi: 10.1038/s41598-019-45323-8.

3.

Targeting mRNA translation in Parkinson's disease.

Correddu D, Leung IKH.

Drug Discov Today. 2019 Jun;24(6):1295-1303. doi: 10.1016/j.drudis.2019.04.003. Epub 2019 Apr 8. Review.

PMID:
30974176
4.

Protein-Small Molecule Interactions by WaterLOGSY.

Huang R, Leung IKH.

Methods Enzymol. 2019;615:477-500. doi: 10.1016/bs.mie.2018.08.020. Epub 2018 Sep 20.

PMID:
30638539
5.

Novel Inhibitors of DNA Repair Enzyme TDP1 Combining Monoterpenoid and Adamantane Fragments.

Mozhaitsev ES, Zakharenko AL, Suslov EV, Korchagina DV, Zakharova OD, Vasil'eva IA, Chepanova AA, Black E, Patel J, Chand R, Reynisson J, Leung IKH, Volcho KP, Salakhutdinov NF, Lavrik OI.

Anticancer Agents Med Chem. 2019;19(4):463-472. doi: 10.2174/1871520619666181207094243.

PMID:
30523770
6.

A Novel Class of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Contains the Octahydro-2H-chromen-4-ol Scaffold.

Li-Zhulanov NS, Zakharenko AL, Chepanova AA, Patel J, Zafar A, Volcho KP, Salakhutdinov NF, Reynisson J, Leung IKH, Lavrik OI.

Molecules. 2018 Sep 26;23(10). pii: E2468. doi: 10.3390/molecules23102468.

7.

Studies on the Substrate Selectivity of the Hypoxia-Inducible Factor Prolyl Hydroxylase 2 Catalytic Domain.

Abboud MI, Chowdhury R, Leung IKH, Lippl K, Loenarz C, Claridge TDW, Schofield CJ.

Chembiochem. 2018 Nov 2;19(21):2262-2267. doi: 10.1002/cbic.201800246. Epub 2018 Sep 26.

PMID:
30144273
8.

Development of NMR and thermal shift assays for the evaluation of Mycobacterium tuberculosis isocitrate lyase inhibitors.

Bhusal RP, Patel K, Kwai BXC, Swartjes A, Bashiri G, Reynisson J, Sperry J, Leung IKH.

Medchemcomm. 2017 Oct 17;8(11):2155-2163. doi: 10.1039/c7md00456g. eCollection 2017 Nov 1.

9.

MCR-1: a promising target for structure-based design of inhibitors to tackle polymyxin resistance.

Son SJ, Huang R, Squire CJ, Leung IKH.

Drug Discov Today. 2019 Jan;24(1):206-216. doi: 10.1016/j.drudis.2018.07.004. Epub 2018 Jul 20. Review.

PMID:
30036574
10.

Total synthesis of the proposed structure of talarolide A.

Zhang S, De Leon Rodriguez LM, Huang R, Leung IKH, Harris PWR, Brimble MA.

Org Biomol Chem. 2018 Jul 25;16(29):5286-5293. doi: 10.1039/c8ob01230j.

PMID:
29989642
11.

2-Oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2.

Abboud MI, McAllister TE, Leung IKH, Chowdhury R, Jorgensen C, Domene C, Mecinović J, Lippl K, Hancock RL, Hopkinson RJ, Kawamura A, Claridge TDW, Schofield CJ.

Chem Commun (Camb). 2018 Mar 28;54(25):3130-3133. doi: 10.1039/c8cc00387d. Epub 2018 Mar 9.

12.

Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials.

Yeh TL, Leissing TM, Abboud MI, Thinnes CC, Atasoylu O, Holt-Martyn JP, Zhang D, Tumber A, Lippl K, Lohans CT, Leung IKH, Morcrette H, Clifton IJ, Claridge TDW, Kawamura A, Flashman E, Lu X, Ratcliffe PJ, Chowdhury R, Pugh CW, Schofield CJ.

Chem Sci. 2017 Nov 1;8(11):7651-7668. doi: 10.1039/c7sc02103h. Epub 2017 Sep 11.

13.

Total Synthesis and Conformational Study of Callyaerin A: Anti-Tubercular Cyclic Peptide Bearing a Rare Rigidifying (Z)-2,3- Diaminoacrylamide Moiety.

Zhang S, De Leon Rodriguez LM, Leung IKH, Cook GM, Harris PWR, Brimble MA.

Angew Chem Int Ed Engl. 2018 Mar 26;57(14):3631-3635. doi: 10.1002/anie.201712792. Epub 2018 Feb 14.

PMID:
29345033
14.

NMR studies of the non-haem Fe(II) and 2-oxoglutarate-dependent oxygenases.

Mbenza NM, Vadakkedath PG, McGillivray DJ, Leung IKH.

J Inorg Biochem. 2017 Dec;177:384-394. doi: 10.1016/j.jinorgbio.2017.08.032. Epub 2017 Sep 4. Review.

PMID:
28893416
15.

Targeting isocitrate lyase for the treatment of latent tuberculosis.

Bhusal RP, Bashiri G, Kwai BXC, Sperry J, Leung IKH.

Drug Discov Today. 2017 Jul;22(7):1008-1016. doi: 10.1016/j.drudis.2017.04.012. Epub 2017 Apr 27. Review.

PMID:
28458043
16.

Protein-ligand binding affinity determination by the waterLOGSY method: An optimised approach considering ligand rebinding.

Huang R, Bonnichon A, Claridge TD, Leung IK.

Sci Rep. 2017 Mar 3;7:43727. doi: 10.1038/srep43727.

17.

Selective recognition of the di/trimethylammonium motif by an artificial carboxycalixarene receptor.

Hanauer T, Hopkinson RJ, Patel K, Li Y, Correddu D, Kawamura A, Sarojini V, Leung IK, Gruber T.

Org Biomol Chem. 2017 Feb 1;15(5):1100-1105. doi: 10.1039/c6ob02616h.

PMID:
28091667
18.

Virtual screening and biophysical studies lead to HSP90 inhibitors.

Huang R, Ayine-Tora DM, Muhammad Rosdi MN, Li Y, Reynisson J, Leung IKH.

Bioorg Med Chem Lett. 2017 Jan 15;27(2):277-281. doi: 10.1016/j.bmcl.2016.11.059. Epub 2016 Nov 23.

PMID:
27913182
19.

Synthesis of the Azepinobisindole Alkaloid Iheyamine A Enabled by a Cross-Mannich Reaction.

Lindsay AC, Leung IKH, Sperry J.

Org Lett. 2016 Oct 21;18(20):5404-5407. doi: 10.1021/acs.orglett.6b02798. Epub 2016 Oct 5.

PMID:
27704854
20.

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.

Chowdhury R, Leung IK, Tian YM, Abboud MI, Ge W, Domene C, Cantrelle FX, Landrieu I, Hardy AP, Pugh CW, Ratcliffe PJ, Claridge TD, Schofield CJ.

Nat Commun. 2016 Aug 26;7:12673. doi: 10.1038/ncomms12673.

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