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Post Meal Energy Boluses Do Not Increase the Duration of Muscle Protein Synthesis Stimulation in Two Anabolic Resistant Situations.

Mosoni L, Jarzaguet M, David J, Polakof S, Savary-Auzeloux I, Rémond D, Dardevet D.

Nutrients. 2019 Mar 29;11(4). pii: E727. doi: 10.3390/nu11040727.


Profound Changes in Net Energy and Nitrogen Metabolites Fluxes within the Splanchnic Area during Overfeeding of Yucatan Mini Pigs That Remain Euglycemic.

Isabelle SA, Ahmed-Ben M, Benoit C, Dominique D, Jérémie D, Noureddine H, Carole M, Estelle PG, Didier R, Sergio P.

Nutrients. 2019 Feb 19;11(2). pii: E434. doi: 10.3390/nu11020434.


Impaired Skeletal Muscle Branched-Chain Amino Acids Catabolism Contributes to Their Increased Circulating Levels in a Non-Obese Insulin-Resistant Fructose-Fed Rat Model.

David J, Dardevet D, Mosoni L, Savary-Auzeloux I, Polakof S.

Nutrients. 2019 Feb 8;11(2). pii: E355. doi: 10.3390/nu11020355.


A mix of dietary fermentable fibers improves lipids handling by the liver of overfed minipigs.

Mohamed AB, Rémond D, Chambon C, Sayd T, Hébraud M, Capel F, Cohade B, Hafnaoui N, Béchet D, Coudy-Gandilhon C, Migné C, David J, Dardevet D, Doré J, Polakof S, Savary-Auzeloux I.

J Nutr Biochem. 2019 Mar;65:72-82. doi: 10.1016/j.jnutbio.2018.12.002. Epub 2018 Dec 8.


Peripheral Blood Mononuclear Cell Metabolism Acutely Adapted to Postprandial Transition and Mainly Reflected Metabolic Adipose Tissue Adaptations to a High-Fat Diet in Minipigs.

Zeng Y, David J, Rémond D, Dardevet D, Savary-Auzeloux I, Polakof S.

Nutrients. 2018 Nov 21;10(11). pii: E1816. doi: 10.3390/nu10111816.


Time-course changes in circulating branched-chain amino acid levels and metabolism in obese Yucatan minipig.

Polakof S, Rémond D, David J, Dardevet D, Savary-Auzeloux I.

Nutrition. 2018 Jun;50:66-73. doi: 10.1016/j.nut.2017.11.004. Epub 2017 Nov 27.


Dietary supplementation with cysteine prevents adverse metabolic outcomes of repeated cures with paracetamol in old rats.

Mast C, Pourpe C, Voyard G, Rémond D, Migné C, Centeno D, Dardevet D, Savary-Auzeloux I, Papet I.

Br J Nutr. 2017 Dec;118(11):889-896. doi: 10.1017/S0007114517002847. Epub 2017 Nov 27.


At same leucine intake, a whey/plant protein blend is not as effective as whey to initiate a transient post prandial muscle anabolic response during a catabolic state in mini pigs.

Revel A, Jarzaguet M, Peyron MA, Papet I, Hafnaoui N, Migné C, Mosoni L, Polakof S, Savary-Auzeloux I, Rémond D, Dardevet D.

PLoS One. 2017 Oct 18;12(10):e0186204. doi: 10.1371/journal.pone.0186204. eCollection 2017.


Metabolic adaptations to HFHS overfeeding: how whole body and tissues postprandial metabolic flexibility adapt in Yucatan mini-pigs.

Polakof S, Rémond D, Bernalier-Donadille A, Rambeau M, Pujos-Guillot E, Comte B, Dardevet D, Savary-Auzeloux I.

Eur J Nutr. 2018 Feb;57(1):119-135. doi: 10.1007/s00394-016-1302-1. Epub 2016 Aug 27.


Chronic Intake of Sucrose Accelerates Sarcopenia in Older Male Rats through Alterations in Insulin Sensitivity and Muscle Protein Synthesis.

Gatineau E, Savary-Auzeloux I, Migné C, Polakof S, Dardevet D, Mosoni L.

J Nutr. 2015 May;145(5):923-30. doi: 10.3945/jn.114.205583. Epub 2015 Mar 25.


Slight chronic elevation of C-reactive protein is associated with lower aerobic fitness but does not impair meal-induced stimulation of muscle protein metabolism in healthy old men.

Buffière C, Mariotti F, Savary-Auzeloux I, Migné C, Meunier N, Hercberg S, Cano N, Rémond D, Duclos M, Dardevet D.

J Physiol. 2015 Mar 1;593(5):1259-72. doi: 10.1113/jphysiol.2014.286054. Epub 2015 Feb 4.


High whey protein intake delayed the loss of lean body mass in healthy old rats, whereas protein type and polyphenol/antioxidant supplementation had no effects.

Mosoni L, Gatineau E, Gatellier P, Migné C, Savary-Auzeloux I, Rémond D, Rocher E, Dardevet D.

PLoS One. 2014 Sep 30;9(9):e109098. doi: 10.1371/journal.pone.0109098. eCollection 2014.


A dietary supplementation with leucine and antioxidants is capable to accelerate muscle mass recovery after immobilization in adult rats.

Savary-Auzeloux I, Magne H, Migné C, Oberli M, Breuillé D, Faure M, Vidal K, Perrot M, Rémond D, Combaret L, Dardevet D.

PLoS One. 2013 Nov 29;8(11):e81495. doi: 10.1371/journal.pone.0081495. eCollection 2013.


Whey proteins are more efficient than casein in the recovery of muscle functional properties following a casting induced muscle atrophy.

Martin V, Ratel S, Siracusa J, Le Ruyet P, Savary-Auzeloux I, Combaret L, Guillet C, Dardevet D.

PLoS One. 2013 Sep 19;8(9):e75408. doi: 10.1371/journal.pone.0075408. eCollection 2013.


Unilateral hindlimb casting induced a delayed generalized muscle atrophy during rehabilitation that is prevented by a whey or a high protein diet but not a free leucine-enriched diet.

Magne H, Savary-Auzeloux I, Migné C, Peyron MA, Combaret L, Rémond D, Dardevet D.

PLoS One. 2013 Aug 27;8(8):e70130. doi: 10.1371/journal.pone.0070130. eCollection 2013.


Nutritional strategies to counteract muscle atrophy caused by disuse and to improve recovery.

Magne H, Savary-Auzeloux I, Rémond D, Dardevet D.

Nutr Res Rev. 2013 Dec;26(2):149-65. doi: 10.1017/S0954422413000115. Epub 2013 Aug 9. Review.


Effects of meat cooking, and of ingested amount, on protein digestion speed and entry of residual proteins into the colon: a study in minipigs.

Bax ML, Buffière C, Hafnaoui N, Gaudichon C, Savary-Auzeloux I, Dardevet D, Santé-Lhoutellier V, Rémond D.

PLoS One. 2013 Apr 12;8(4):e61252. doi: 10.1371/journal.pone.0061252. Print 2013.


Muscle wasting and resistance of muscle anabolism: the "anabolic threshold concept" for adapted nutritional strategies during sarcopenia.

Dardevet D, Rémond D, Peyron MA, Papet I, Savary-Auzeloux I, Mosoni L.

ScientificWorldJournal. 2012;2012:269531. doi: 10.1100/2012/269531. Epub 2012 Dec 23. Review.


Commentaries on Viewpoint: Muscle atrophy is not always sarcopenia.

Dardevet D, Savary-Auzeloux I, Remond D, Mosoni L, Marzetti E, Buford TW, Bernabei R, Dionne IJ, Buford TW, Marzetti E, Manini TM, Buehring B, Kirchner E, Calabrese L, Manini TM, Clark BC, Fonseca HM, Delbono O, Taylor JR, Aubertin-Leheudre M, Barbat-Artigas S, Pion CH, Thornell LE, Gustafsson T, Cederholm T, Ulfhake B.

J Appl Physiol (1985). 2012 Aug 15;113(4):680-4. doi: 10.1152/japplphysiol.00667.2012. No abstract available.


Contrarily to whey and high protein diets, dietary free leucine supplementation cannot reverse the lack of recovery of muscle mass after prolonged immobilization during ageing.

Magne H, Savary-Auzeloux I, Migné C, Peyron MA, Combaret L, Rémond D, Dardevet D.

J Physiol. 2012 Apr 15;590(8):2035-49. doi: 10.1113/jphysiol.2011.226266. Epub 2012 Feb 20.

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