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Items: 1 to 20 of 33


Developing a Food Exposure and Urine Sampling Strategy for Dietary Exposure Biomarker Validation in Free-Living Individuals.

Lloyd AJ, Willis ND, Wilson T, Zubair H, Xie L, Chambers E, Garcia-Perez I, Tailliart K, Beckmann M, Mathers JC, Draper J.

Mol Nutr Food Res. 2019 Jun 3:e1900062. doi: 10.1002/mnfr.201900062. [Epub ahead of print]


Effects of Inulin Propionate Ester Incorporated into Palatable Food Products on Appetite and Resting Energy Expenditure: A Randomised Crossover Study.

Byrne CS, Chambers ES, Preston T, Tedford C, Brignardello J, Garcia-Perez I, Holmes E, Wallis GA, Morrison DJ, Frost GS.

Nutrients. 2019 Apr 16;11(4). pii: E861. doi: 10.3390/nu11040861.


Dietary supplementation with inulin-propionate ester or inulin improves insulin sensitivity in adults with overweight and obesity with distinct effects on the gut microbiota, plasma metabolome and systemic inflammatory responses: a randomised cross-over trial.

Chambers ES, Byrne CS, Morrison DJ, Murphy KG, Preston T, Tedford C, Garcia-Perez I, Fountana S, Serrano-Contreras JI, Holmes E, Reynolds CJ, Roberts JF, Boyton RJ, Altmann DM, McDonald JAK, Marchesi JR, Akbar AN, Riddell NE, Wallis GA, Frost GS.

Gut. 2019 Apr 10. pii: gutjnl-2019-318424. doi: 10.1136/gutjnl-2019-318424. [Epub ahead of print]


The effect of L-rhamnose on intestinal transit time, short chain fatty acids and appetite regulation: a pilot human study using combined 13CO2/H2 breath tests.

Byrne CS, Preston T, Brignardello J, Garcia-Perez I, Holmes E, Frost GS, Morrison DJ.

J Breath Res. 2018 Aug 6;12(4):046006. doi: 10.1088/1752-7163/aad3f1.


A Prospective Metagenomic and Metabolomic Analysis of the Impact of Exercise and/or Whey Protein Supplementation on the Gut Microbiome of Sedentary Adults.

Cronin O, Barton W, Skuse P, Penney NC, Garcia-Perez I, Murphy EF, Woods T, Nugent H, Fanning A, Melgar S, Falvey EC, Holmes E, Cotter PD, O'Sullivan O, Molloy MG, Shanahan F.

mSystems. 2018 Apr 24;3(3). pii: e00044-18. doi: 10.1128/mSystems.00044-18. eCollection 2018 May-Jun.


Optimized Phenotypic Biomarker Discovery and Confounder Elimination via Covariate-Adjusted Projection to Latent Structures from Metabolic Spectroscopy Data.

Posma JM, Garcia-Perez I, Ebbels TMD, Lindon JC, Stamler J, Elliott P, Holmes E, Nicholson JK.

J Proteome Res. 2018 Apr 6;17(4):1586-1595. doi: 10.1021/acs.jproteome.7b00879. Epub 2018 Feb 27.


The microbiome of professional athletes differs from that of more sedentary subjects in composition and particularly at the functional metabolic level.

Barton W, Penney NC, Cronin O, Garcia-Perez I, Molloy MG, Holmes E, Shanahan F, Cotter PD, O'Sullivan O.

Gut. 2018 Apr;67(4):625-633. doi: 10.1136/gutjnl-2016-313627. Epub 2017 Mar 30.


Integrated Analytical and Statistical Two-Dimensional Spectroscopy Strategy for Metabolite Identification: Application to Dietary Biomarkers.

Posma JM, Garcia-Perez I, Heaton JC, Burdisso P, Mathers JC, Draper J, Lewis M, Lindon JC, Frost G, Holmes E, Nicholson JK.

Anal Chem. 2017 Mar 21;89(6):3300-3309. doi: 10.1021/acs.analchem.6b03324. Epub 2017 Mar 10.


Objective assessment of dietary patterns by use of metabolic phenotyping: a randomised, controlled, crossover trial.

Garcia-Perez I, Posma JM, Gibson R, Chambers ES, Hansen TH, Vestergaard H, Hansen T, Beckmann M, Pedersen O, Elliott P, Stamler J, Nicholson JK, Draper J, Mathers JC, Holmes E, Frost G.

Lancet Diabetes Endocrinol. 2017 Mar;5(3):184-195. doi: 10.1016/S2213-8587(16)30419-3. Epub 2017 Jan 13.


Multiplatform serum metabolic phenotyping combined with pathway mapping to identify biochemical differences in smokers.

Kaluarachchi MR, Boulangé CL, Garcia-Perez I, Lindon JC, Minet EF.

Bioanalysis. 2016 Oct;8(19):2023-43. doi: 10.4155/bio-2016-0108. Epub 2016 Sep 16.


NMR-Based Metabonomic Analysis of Physiological Responses to Starvation and Refeeding in the Rat.

Serrano-Contreras JI, García-Pérez I, Meléndez-Camargo ME, Zepeda LG.

J Proteome Res. 2016 Sep 2;15(9):3241-54. doi: 10.1021/acs.jproteome.6b00433. Epub 2016 Aug 22.


Increased colonic propionate reduces anticipatory reward responses in the human striatum to high-energy foods.

Byrne CS, Chambers ES, Alhabeeb H, Chhina N, Morrison DJ, Preston T, Tedford C, Fitzpatrick J, Irani C, Busza A, Garcia-Perez I, Fountana S, Holmes E, Goldstone AP, Frost GS.

Am J Clin Nutr. 2016 Jul;104(1):5-14. doi: 10.3945/ajcn.115.126706. Epub 2016 May 11.


An Analytical Pipeline for Quantitative Characterization of Dietary Intake: Application To Assess Grape Intake.

Garcia-Perez I, Posma JM, Chambers ES, Nicholson JK, C Mathers J, Beckmann M, Draper J, Holmes E, Frost G.

J Agric Food Chem. 2016 Mar 23;64(11):2423-31. doi: 10.1021/acs.jafc.5b05878. Epub 2016 Mar 8.


NMR-based metabonomic analysis of normal rat urine and faeces in response to (±)-venlafaxine treatment.

Serrano-Contreras JI, García-Pérez I, Meléndez-Camargo ME, Zepeda-Vallejo LG.

J Pharm Biomed Anal. 2016 May 10;123:82-92. doi: 10.1016/j.jpba.2016.01.044. Epub 2016 Feb 1.


Randomised controlled pilot study to assess the feasibility of a Mediterranean Portfolio dietary intervention for cardiovascular risk reduction in HIV dyslipidaemia: a study protocol.

Stradling C, Thomas GN, Hemming K, Frost G, Garcia-Perez I, Redwood S, Taheri S.

BMJ Open. 2016 Feb 8;6(2):e010821. doi: 10.1136/bmjopen-2015-010821.


Multiplatform characterization of dynamic changes in breast milk during lactation.

Andreas NJ, Hyde MJ, Gomez-Romero M, Lopez-Gonzalvez MA, Villaseñor A, Wijeyesekera A, Barbas C, Modi N, Holmes E, Garcia-Perez I.

Electrophoresis. 2015 Sep;36(18):2269-2285. doi: 10.1002/elps.201500011. Epub 2015 Jun 25.


Urinary metabolic signatures of human adiposity.

Elliott P, Posma JM, Chan Q, Garcia-Perez I, Wijeyesekera A, Bictash M, Ebbels TM, Ueshima H, Zhao L, van Horn L, Daviglus M, Stamler J, Holmes E, Nicholson JK.

Sci Transl Med. 2015 Apr 29;7(285):285ra62. doi: 10.1126/scitranslmed.aaa5680. Epub 2015 Apr 29.


Application of CE-MS to a metabonomics study of human urine from cigarette smokers and non-smokers.

Garcia-Perez I, Lindon JC, Minet E.

Bioanalysis. 2014 Oct;6(20):2733-49. doi: 10.4155/bio.14.136.


The urinary proteome and metabonome differ from normal in adults with mitochondrial disease.

Hall AM, Vilasi A, Garcia-Perez I, Lapsley M, Alston CL, Pitceathly RD, McFarland R, Schaefer AM, Turnbull DM, Beaumont NJ, Hsuan JJ, Cutillas PR, Lindon JC, Holmes E, Unwin RJ, Taylor RW, Gorman GS, Rahman S, Hanna MG.

Kidney Int. 2015 Mar;87(3):610-22. doi: 10.1038/ki.2014.297. Epub 2014 Sep 10.


Breast milk metabolome characterization in a single-phase extraction, multiplatform analytical approach.

Villaseñor A, Garcia-Perez I, Garcia A, Posma JM, Fernández-López M, Nicholas AJ, Modi N, Holmes E, Barbas C.

Anal Chem. 2014 Aug 19;86(16):8245-52. doi: 10.1021/ac501853d. Epub 2014 Aug 6.


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