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Anaerobe. 2017 Dec;48:165-171. doi: 10.1016/j.anaerobe.2017.07.008. Epub 2017 Aug 2.

Spontaneous C. septicum gas gangrene: A literature review.

Author information

1
Boise VA Medical Center, Boise, ID 83702, USA. Electronic address: drirasrivastava@gmail.com.
2
Boise VA Medical Center, Boise, ID 83702, USA.
3
Boise VA Medical Center, Boise, ID 83702, USA. Electronic address: dlstevens@mindspring.com.

Abstract

As the infectious disease paradigm undergoes a subtle shift, unusual infections associated with malignancy and immunosuppression are being increasingly reported. Spontaneous or non-traumatic Clostridium septicum infection is one such unusual infection which has gained prominence. This article aims to understand the pathophysiology, clinical manifestations and current trends in diagnosing and treating this rare but deadly infection. To understand the multifactorial causation of this infection a review of published cases of spontaneous C. septicum gas gangrene was performed and a total of 94 such cases were identified. Several factors were analyzed for each case: age, infection location and underlying illness, presenting signs and symptoms, neutropenia, gross pathology of the colon, antibiotic use, surgical intervention, and survival. A known or occult malignancy was present in 71% patients and an overall mortality of 67% was observed.

KEYWORDS:

C. septicum; Clostridium; Gas gangrene; Myonecrosis

PMID:
28780428
DOI:
10.1016/j.anaerobe.2017.07.008
[Indexed for MEDLINE]

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