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Medicina (Kaunas). 2018 May 28;54(3). pii: E36. doi: 10.3390/medicina54030036.

Genetic Markers for Coronary Artery Disease.

Author information

1
Centre for Multidisciplinary Research and Engineering, Institute of Nuclear Science Vinca, University of Belgrade, 11000 Belgrade, Serbia. nevenav@vin.bg.ac.rs.
2
Laboratory of Radiobiology and Molecular Genetics, Institute of Nuclear Science Vinca, University of Belgrade, 11000 Belgrade, Serbia. bzaric@hotmail.com.
3
Department for Endocrinology and Immunoradiology 11080 Zemun, Institute for the Application of Nuclear Energy-INEP, University of Belgrade, 11000 Belgrade, Serbia. ilona.marecko@gmail.com.
4
Laboratory of Radiobiology and Molecular Genetics, Institute of Nuclear Science Vinca, University of Belgrade, 11000 Belgrade, Serbia. obradovicmilan@hotmail.com.
5
Laboratory of Radiobiology and Molecular Genetics, Institute of Nuclear Science Vinca, University of Belgrade, 11000 Belgrade, Serbia. emma_crash@yahoo.com.
6
School of Medicine, Dedinje Cardiovascular Institute, University of Belgrade, 11000 Belgrade, Serbia. radak@ikvbd.com.
7
Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia. radak@ikvbd.com.
8
Serbian Academy of Sciences and Arts, 11000 Belgrade, Serbia. radak@ikvbd.com.
9
Laboratory of Radiobiology and Molecular Genetics, Institute of Nuclear Science Vinca, University of Belgrade, 11000 Belgrade, Serbia. isenovic@yahoo.com.

Abstract

Coronary artery disease (CAD) and myocardial infarction (MI) are recognized as leading causes of mortality in developed countries. Although typically associated with behavioral risk factors, such as smoking, sedentary lifestyle, and poor dietary habits, such vascular phenotypes have also long been recognized as being related to genetic background. We review the currently available data concerning genetic markers for CAD in English and non-English articles with English abstracts published between 2003 and 2018. As genetic testing is increasingly available, it may be possible to identify adequate genetic markers representing the risk profile and to use them in a clinical setting.

KEYWORDS:

GWAS analysis; coronary artery disease; familial hypercholesterolemia; genetic markers

PMID:
30344267
PMCID:
PMC6122104
DOI:
10.3390/medicina54030036
[Indexed for MEDLINE]
Free PMC Article

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