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Items: 1 to 20 of 135

1.

A salvage pathway maintains highly functional respiratory complex I.

Szczepanowska K, Senft K, Heidler J, Herholz M, Kukat A, Höhne MN, Hofsetz E, Becker C, Kaspar S, Giese H, Zwicker K, Guerrero-Castillo S, Baumann L, Kauppila J, Rumyantseva A, Müller S, Frese CK, Brandt U, Riemer J, Wittig I, Trifunovic A.

Nat Commun. 2020 Apr 2;11(1):1643. doi: 10.1038/s41467-020-15467-7.

PMID:
32242014
2.

SRSF7 maintains its homeostasis through the expression of Split-ORFs and nuclear body assembly.

Königs V, de Oliveira Freitas Machado C, Arnold B, Blümel N, Solovyeva A, Löbbert S, Schafranek M, Ruiz De Los Mozos I, Wittig I, McNicoll F, Schulz MH, Müller-McNicoll M.

Nat Struct Mol Biol. 2020 Mar;27(3):260-273. doi: 10.1038/s41594-020-0385-9. Epub 2020 Mar 2.

3.

Cyp2c44 regulates prostaglandin synthesis, lymphangiogenesis, and metastasis in a mouse model of breast cancer.

Kesavan R, Frömel T, Zukunft S, Laban H, Geyer A, Naeem Z, Heidler J, Wittig I, Elwakeel E, Brüne B, Weigert A, Popp R, Fleming I.

Proc Natl Acad Sci U S A. 2020 Mar 17;117(11):5923-5930. doi: 10.1073/pnas.1921381117. Epub 2020 Mar 2.

PMID:
32123095
4.

Respiratory chain signalling is essential for adaptive remodelling following cardiac ischaemia.

Szibor M, Schreckenberg R, Gizatullina Z, Dufour E, Wiesnet M, Dhandapani PK, Debska-Vielhaber G, Heidler J, Wittig I, Nyman TA, Gärtner U, Hall AR, Pell V, Viscomi C, Krieg T, Murphy MP, Braun T, Gellerich FN, Schlüter KD, Jacobs HT.

J Cell Mol Med. 2020 Feb 10. doi: 10.1111/jcmm.15043. [Epub ahead of print]

5.

Pathogenic Bi-allelic Mutations in NDUFAF8 Cause Leigh Syndrome with an Isolated Complex I Deficiency.

Alston CL, Veling MT, Heidler J, Taylor LS, Alaimo JT, Sung AY, He L, Hopton S, Broomfield A, Pavaine J, Diaz J, Leon E, Wolf P, McFarland R, Prokisch H, Wortmann SB, Bonnen PE, Wittig I, Pagliarini DJ, Taylor RW.

Am J Hum Genet. 2020 Jan 2;106(1):92-101. doi: 10.1016/j.ajhg.2019.12.001. Epub 2019 Dec 19.

6.

High-resolution cryo-EM structures of respiratory complex I: Mechanism, assembly, and disease.

Parey K, Haapanen O, Sharma V, Köfeler H, Züllig T, Prinz S, Siegmund K, Wittig I, Mills DJ, Vonck J, Kühlbrandt W, Zickermann V.

Sci Adv. 2019 Dec 11;5(12):eaax9484. doi: 10.1126/sciadv.aax9484. eCollection 2019 Dec.

7.

Identification of TRIM25 as a Negative Regulator of Caspase-2 Expression Reveals a Novel Target for Sensitizing Colon Carcinoma Cells to Intrinsic Apoptosis.

Nasrullah U, Haeussler K, Biyanee A, Wittig I, Pfeilschifter J, Eberhardt W.

Cells. 2019 Dec 12;8(12). pii: E1622. doi: 10.3390/cells8121622.

8.

Bioenergetic consequences from xenotopic expression of a tunicate AOX in mouse mitochondria: Switch from RET and ROS to FET.

Szibor M, Gainutdinov T, Fernandez-Vizarra E, Dufour E, Gizatullina Z, Debska-Vielhaber G, Heidler J, Wittig I, Viscomi C, Gellerich F, Moore AL.

Biochim Biophys Acta Bioenerg. 2020 Feb 1;1861(2):148137. doi: 10.1016/j.bbabio.2019.148137. Epub 2019 Dec 9.

9.

Global Proteome of LonP1+/- Mouse Embryonal Fibroblasts Reveals Impact on Respiratory Chain, but No Interdependence between Eral1 and Mitoribosomes.

Key J, Kohli A, Bárcena C, López-Otín C, Heidler J, Wittig I, Auburger G.

Int J Mol Sci. 2019 Sep 12;20(18). pii: E4523. doi: 10.3390/ijms20184523.

10.

Activation of Caspase-6 Is Promoted by a Mutant Huntingtin Fragment and Blocked by an Allosteric Inhibitor Compound.

Ehrnhoefer DE, Skotte NH, Reinshagen J, Qiu X, Windshügel B, Jaishankar P, Ladha S, Petina O, Khankischpur M, Nguyen YTN, Caron NS, Razeto A, Meyer Zu Rheda M, Deng Y, Huynh KT, Wittig I, Gribbon P, Renslo AR, Geffken D, Gul S, Hayden MR.

Cell Chem Biol. 2019 Sep 19;26(9):1295-1305.e6. doi: 10.1016/j.chembiol.2019.07.001. Epub 2019 Jul 25.

PMID:
31353319
11.

Nitric oxide maintains endothelial redox homeostasis through PKM2 inhibition.

Siragusa M, Thöle J, Bibli SI, Luck B, Loot AE, de Silva K, Wittig I, Heidler J, Stingl H, Randriamboavonjy V, Kohlstedt K, Brüne B, Weigert A, Fisslthaler B, Fleming I.

EMBO J. 2019 Sep 2;38(17):e100938. doi: 10.15252/embj.2018100938. Epub 2019 Jul 22.

PMID:
31328803
12.

Myeloid-Specific Deletion of the AMPKα2 Subunit Alters Monocyte Protein Expression and Atherogenesis.

Fisslthaler B, Zippel N, Abdel Malik R, Delgado Lagos F, Zukunft S, Thoele J, Siuda D, Soehnlein O, Wittig I, Heidler J, Weigert A, Fleming I.

Int J Mol Sci. 2019 Jun 19;20(12). pii: E3005. doi: 10.3390/ijms20123005.

13.

Mutations in a conserved loop in the PSST subunit of respiratory complex I affect ubiquinone binding and dynamics.

Galemou Yoga E, Haapanen O, Wittig I, Siegmund K, Sharma V, Zickermann V.

Biochim Biophys Acta Bioenerg. 2019 Jul 1;1860(7):573-581. doi: 10.1016/j.bbabio.2019.06.006. Epub 2019 Jun 19.

14.

AKAP12 deficiency impairs VEGF-induced endothelial cell migration and sprouting.

Benz PM, Ding Y, Stingl H, Loot AE, Zink J, Wittig I, Popp R, Fleming I.

Acta Physiol (Oxf). 2020 Jan;228(1):e13325. doi: 10.1111/apha.13325. Epub 2019 Jun 21.

15.

Redox-Dependent Loss of Flavin by Mitochondrial Complex I in Brain Ischemia/Reperfusion Injury.

Stepanova A, Sosunov S, Niatsetskaya Z, Konrad C, Starkov AA, Manfredi G, Wittig I, Ten V, Galkin A.

Antioxid Redox Signal. 2019 Sep 20;31(9):608-622. doi: 10.1089/ars.2018.7693. Epub 2019 Jul 1.

PMID:
31037949
16.

TLR2-Dependent Reversible Oxidation of Connexin 43 at Cys260 Modifies Electrical Coupling After Experimental Myocardial Ischemia/Reperfusion.

Raimann FJ, Dröse S, Bonke E, Schneider L, Tybl E, Wittig I, Heidler J, Heide H, Josipovic I, Leisegang M, Brandes RP, Roeper J, Zacharowski K, Mersmann J.

J Cardiovasc Transl Res. 2019 Oct;12(5):478-487. doi: 10.1007/s12265-019-09887-0. Epub 2019 Apr 8.

PMID:
30963423
17.

The polarity protein Scrib limits atherosclerosis development in mice.

Schürmann C, Dienst FL, Pálfi K, Vasconez AE, Oo JA, Wang S, Buchmann GK, Offermanns S, van de Sluis B, Leisegang MS, Günther S, Humbert PO, Lee E, Zhu J, Weigert A, Mathoor P, Wittig I, Kruse C, Brandes RP.

Cardiovasc Res. 2019 Dec 1;115(14):1963-1974. doi: 10.1093/cvr/cvz093.

PMID:
30949676
18.

BIAM switch assay coupled to mass spectrometry identifies novel redox targets of NADPH oxidase 4.

Löwe O, Rezende F, Heidler J, Wittig I, Helfinger V, Brandes RP, Schröder K.

Redox Biol. 2019 Feb;21:101125. doi: 10.1016/j.redox.2019.101125. Epub 2019 Jan 29.

19.

Redox Activation of Nox1 (NADPH Oxidase 1) Involves an Intermolecular Disulfide Bond Between Protein Disulfide Isomerase and p47phox in Vascular Smooth Muscle Cells.

Gimenez M, Veríssimo-Filho S, Wittig I, Schickling BM, Hahner F, Schürmann C, Netto LES, Rosa JC, Brandes RP, Sartoretto S, De Lucca Camargo L, Abdulkader F, Miller FJ Jr, Lopes LR.

Arterioscler Thromb Vasc Biol. 2019 Feb;39(2):224-236. doi: 10.1161/ATVBAHA.118.311038.

20.

Deep proteome of human nNOS/NOS1-positive versus MOCK SH-SY5Y neuroblastoma cells under full nutrition, serum free starvation and rapamycin treatment.

Heidler J, Valek L, Wittig I, Tegeder I.

Data Brief. 2018 Oct 26;21:1309-1314. doi: 10.1016/j.dib.2018.10.079. eCollection 2018 Dec.

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