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Characterization of Vitamin A Metabolome in Human Livers With and Without Nonalcoholic Fatty Liver Disease.

Zhong G, Kirkwood J, Won KJ, Tjota N, Jeong H, Isoherranen N.

J Pharmacol Exp Ther. 2019 Jul;370(1):92-103. doi: 10.1124/jpet.119.258517. Epub 2019 May 1.


Determinants of Cytochrome P450 2D6 mRNA Levels in Healthy Human Liver Tissue.

Ning M, Duarte JD, Stevison F, Isoherranen N, Rubin LH, Jeong H.

Clin Transl Sci. 2019 Mar 1. doi: 10.1111/cts.12632. [Epub ahead of print]


Repression of hepatocyte nuclear factor 4 alpha by AP-1 underlies dyslipidemia associated with retinoic acid.

Won KJ, Park JS, Jeong H.

J Lipid Res. 2019 Apr;60(4):794-804. doi: 10.1194/jlr.M088880. Epub 2019 Feb 1.


Commensal Gut Bacteria Convert the Immunosuppressant Tacrolimus to Less Potent Metabolites.

Guo Y, Crnkovic CM, Won KJ, Yang X, Lee JR, Orjala J, Lee H, Jeong H.

Drug Metab Dispos. 2019 Mar;47(3):194-202. doi: 10.1124/dmd.118.084772. Epub 2018 Dec 31.


Inhibitory and Inductive Effects of Opuntia ficus indica Extract and Its Flavonoid Constituents on Cytochrome P450s and UDP-Glucuronosyltransferases.

Jeong H, Kim S, Kim MY, Lee J, An BH, Kim HD, Jeong H, Song YS, Chang M.

Int J Mol Sci. 2018 Oct 30;19(11). pii: E3400. doi: 10.3390/ijms19113400.


A Family of Small Intrinsically Disordered Proteins Involved in Flagellum-Dependent Motility in Salmonella enterica.

Oguri T, Kwon Y, Woo JKK, Prehna G, Lee H, Ning M, Won KJ, Lee J, Mei S, Shi Y, Jeong H, Lee H.

J Bacteriol. 2018 Dec 20;201(2). pii: e00415-18. doi: 10.1128/JB.00415-18. Print 2019 Jan 15.


Ten Years' Experience with the CYP2D6 Activity Score: A Perspective on Future Investigations to Improve Clinical Predictions for Precision Therapeutics.

Gaedigk A, Dinh JC, Jeong H, Prasad B, Leeder JS.

J Pers Med. 2018 Apr 17;8(2). pii: E15. doi: 10.3390/jpm8020015. Review.


Physiological Regulation of Drug Metabolism and Transport: Pregnancy, Microbiome, Inflammation, Infection, and Fasting.

Morgan ET, Dempsey JL, Mimche SM, Lamb TJ, Kulkarni S, Cui JY, Jeong H, Slitt AL.

Drug Metab Dispos. 2018 May;46(5):503-513. doi: 10.1124/dmd.117.079905. Epub 2018 Mar 7.


The FDA-approved anti-cancer drugs, streptozotocin and floxuridine, reduce the virulence of Staphylococcus aureus.

Yeo WS, Arya R, Kim KK, Jeong H, Cho KH, Bae T.

Sci Rep. 2018 Feb 6;8(1):2521. doi: 10.1038/s41598-018-20617-5.


CYP2D6 Protein Level Is the Major Contributor to Interindividual Variability in CYP2D6-Mediated Drug Metabolism in Healthy Human Liver Tissue.

Ning M, Duarte JD, Rubin LH, Jeong H.

Clin Pharmacol Ther. 2018 Nov;104(5):974-982. doi: 10.1002/cpt.1032. Epub 2018 Feb 13.


Daikenchuto (TU-100) alters murine hepatic and intestinal drug metabolizing enzymes in an in vivo dietary model: effects of gender and withdrawal.

Nobutani K, Miyoshi J, Musch MW, Nishiyama M, Watanabe J, Kaneko A, Yamamoto M, Yoshida M, Kono T, Jeong H, Chang EB.

Pharmacol Res Perspect. 2017 Oct;5(5). doi: 10.1002/prp2.361.


Fructose diet alleviates acetaminophen-induced hepatotoxicity in mice.

Cho S, Tripathi A, Chlipala G, Green S, Lee H, Chang EB, Jeong H.

PLoS One. 2017 Aug 23;12(8):e0182977. doi: 10.1371/journal.pone.0182977. eCollection 2017.


Dual Inhibition of NOX2 and Receptor Tyrosine Kinase by BJ-1301 Enhances Anticancer Therapy Efficacy via Suppression of Autocrine-Stimulatory Factors in Lung Cancer.

Gautam J, Ku JM, Regmi SC, Jeong H, Wang Y, Banskota S, Park MH, Nam TG, Jeong BS, Kim JA.

Mol Cancer Ther. 2017 Oct;16(10):2144-2156. doi: 10.1158/1535-7163.MCT-16-0915. Epub 2017 May 23.


High-Fat Diet Feeding Alters Expression of Hepatic Drug-Metabolizing Enzymes in Mice.

Ning M, Jeong H.

Drug Metab Dispos. 2017 Jul;45(7):707-711. doi: 10.1124/dmd.117.075655. Epub 2017 Apr 25.


Effects of Fenofibrate on the Expression of Small Heterodimer Partner (SHP) and Cytochrome P450 (CYP) 2D6.

Kent R, Jeong H.

Drug Metab Lett. 2017 Nov 17;11(1):68-72. doi: 10.2174/1872312811666170407164631.


Regulation of drug metabolism and toxicity by multiple factors of genetics, epigenetics, lncRNAs, gut microbiota, and diseases: a meeting report of the 21st International Symposium on Microsomes and Drug Oxidations (MDO).

Yu AM, Ingelman-Sundberg M, Cherrington NJ, Aleksunes LM, Zanger UM, Xie W, Jeong H, Morgan ET, Turnbaugh PJ, Klaassen CD, Bhatt AP, Redinbo MR, Hao P, Waxman DJ, Wang L, Zhong XB.

Acta Pharm Sin B. 2017 Mar;7(2):241-248. doi: 10.1016/j.apsb.2016.12.006. Epub 2017 Feb 1.


Cholic Acid Feeding Leads to Increased CYP2D6 Expression in CYP2D6-Humanized Mice.

Pan X, Kent R, Won KJ, Jeong H.

Drug Metab Dispos. 2017 Apr;45(4):346-352. doi: 10.1124/dmd.116.074013. Epub 2017 Feb 2.


Tryptophan hydroxylase 1 and 5-HT7 receptor preferentially expressed in triple-negative breast cancer promote cancer progression through autocrine serotonin signaling.

Gautam J, Banskota S, Regmi SC, Ahn S, Jeon YH, Jeong H, Kim SJ, Nam TG, Jeong BS, Kim JA.

Mol Cancer. 2016 Nov 21;15(1):75.


17β-Estradiol up-regulates UDP-glucuronosyltransferase 1A9 expression via estrogen receptor α.

Cho SJ, Ning M, Zhang Y, Rubin LH, Jeong H.

Acta Pharm Sin B. 2016 Sep;6(5):504-509. Epub 2016 May 20.


Transcriptional Regulation of CYP2D6 Expression.

Pan X, Ning M, Jeong H.

Drug Metab Dispos. 2017 Jan;45(1):42-48. Epub 2016 Oct 3. Review.

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