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Nanomaterials (Basel). 2019 Feb 1;9(2). pii: E184. doi: 10.3390/nano9020184.

Poly(vinylidene fluoride) Composite Nanofibers Containing Polyhedral Oligomeric Silsesquioxane⁻Epigallocatechin Gallate Conjugate for Bone Tissue Regeneration.

Author information

1
Department of Biomedical Engineering, Daegu Catholic University, Gyeongsan 38430, Korea. jhg2833@empal.com.
2
Department of Advanced Materials and Chemical Engineering, Daegu Catholic University, Gyeongsan 38430, Korea. yshancu@cu.ac.kr.
3
Department of Advanced Materials and Chemical Engineering, Daegu Catholic University, Gyeongsan 38430, Korea. khjung@cu.ac.kr.
4
Department of Biomedical Engineering, Daegu Catholic University, Gyeongsan 38430, Korea. yjkim@cu.ac.kr.

Abstract

To provide adequate conditions for the regeneration of damaged bone, it is necessary to develop piezoelectric porous membranes with antioxidant and anti-inflammatory activities. In this study, composite nanofibers comprising poly(vinylidene fluoride) (PVDF) and a polyhedral oligomeric silsesquioxane⁻epigallocatechin gallate (POSS⁻EGCG) conjugate were fabricated by electrospinning methods. The resulting composite nanofibers showed three-dimensionally interconnected porous structures. Their average diameters, ranging from 936 ± 223 nm to 1094 ± 394 nm, were hardly affected by the addition of the POSS⁻EGCG conjugate. On the other hand, the piezoelectric β-phase increased significantly from 77.4% to 88.1% after adding the POSS⁻EGCG conjugate. The mechanical strength of the composite nanofibers was ameliorated by the addition of the POSS⁻EGCG conjugate. The results of in vitro bioactivity tests exhibited that the proliferation and differentiation of osteoblasts (MC3T3-E1) on the nanofibers increased with the content of POSS⁻EGCG conjugate because of the improved piezoelectricity and antioxidant and anti-inflammatory properties of the nanofibers. All results could suggest that the PVDF composite nanofibers were effective for guided bone regeneration.

KEYWORDS:

antioxidant activity; bone regeneration; composite nanofiber; piezoelectricity; poly(vinylidene fluoride)

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