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LY303511 displays antiproliferation potential against oral cancer cells in vitro and in vivo.

Tang JY, Xu YH, Lin LC, Ou-Yang F, Wu KH, Tsao LY, Yu TJ, Huang HW, Wang HR, Liu W, Chang HW.

Environ Toxicol. 2019 Aug;34(8):958-967. doi: 10.1002/tox.22767. Epub 2019 May 21.


Combination Therapy of Chloroquine and C₂-Ceramide Enhances Cytotoxicity in Lung Cancer H460 and H1299 Cells.

Chou HL, Lin YH, Liu W, Wu CY, Li RN, Huang HW, Chou CH, Chiou SJ, Chiu CC.

Cancers (Basel). 2019 Mar 15;11(3). pii: E370. doi: 10.3390/cancers11030370.


Reduced camptothecin sensitivity of estrogen receptor-positive human breast cancer cells following exposure to di(2-ethylhexyl)phthalate (DEHP) is associated with DNA methylation changes.

Chou CK, Huang HW, Yang CF, Dahms HU, Liang SS, Wang TN, Kuo PL, Hsi E, Tsai EM, Chiu CC.

Environ Toxicol. 2019 Apr;34(4):401-414. doi: 10.1002/tox.22694. Epub 2019 Feb 5.


Oxidative stress-modulating drugs have preferential anticancer effects - involving the regulation of apoptosis, DNA damage, endoplasmic reticulum stress, autophagy, metabolism, and migration.

Tang JY, Ou-Yang F, Hou MF, Huang HW, Wang HR, Li KT, Fayyaz S, Shu CW, Chang HW.

Semin Cancer Biol. 2018 Aug 24. pii: S1044-579X(18)30084-1. doi: 10.1016/j.semcancer.2018.08.010. [Epub ahead of print] Review.


Correction: Huang, H.W.; et al. Sinularin Selectively Kills Breast Cancer Cells Showing G2/M Arrest, Apoptosis, and Oxidative DNA Damage. Molecules 2018, 23, 849.

Huang HW, Tang JY, Ou-Yang F, Wang HR, Guan PY, Huang CY, Chen CY, Hou MF, Sheu JH, Chang HW.

Molecules. 2018 Jul 9;23(7). pii: E1670. doi: 10.3390/molecules23071670.


Sinularin Selectively Kills Breast Cancer Cells Showing G2/M Arrest, Apoptosis, and Oxidative DNA Damage.

Huang HW, Tang JY, Ou-Yang F, Wang HR, Guan PY, Huang CY, Chen CY, Hou MF, Sheu JH, Chang HW.

Molecules. 2018 Apr 8;23(4). pii: E849. doi: 10.3390/molecules23040849. Erratum in: Molecules. 2018 Jul 09;23(7):.


4β-Hydroxywithanolide E selectively induces oxidative DNA damage for selective killing of oral cancer cells.

Tang JY, Huang HW, Wang HR, Chan YC, Haung JW, Shu CW, Wu YC, Chang HW.

Environ Toxicol. 2018 Mar;33(3):295-304. doi: 10.1002/tox.22516. Epub 2017 Nov 22.


Withaferin A Induces Oxidative Stress-Mediated Apoptosis and DNA Damage in Oral Cancer Cells.

Chang HW, Li RN, Wang HR, Liu JR, Tang JY, Huang HW, Chan YH, Yen CY.

Front Physiol. 2017 Sep 7;8:634. doi: 10.3389/fphys.2017.00634. eCollection 2017.


TRAIL, Wnt, Sonic Hedgehog, TGFβ, and miRNA Signalings Are Potential Targets for Oral Cancer Therapy.

Farooqi AA, Shu CW, Huang HW, Wang HR, Chang YT, Fayyaz S, Yuan SF, Tang JY, Chang HW.

Int J Mol Sci. 2017 Jul 14;18(7). pii: E1523. doi: 10.3390/ijms18071523. Review.


An Acetamide Derivative as a Camptothecin Sensitizer for Human Non-Small-Cell Lung Cancer Cells through Increased Oxidative Stress and JNK Activation.

Chou HL, Fong Y, Lin HH, Tsai EM, Chen JY, Chang WT, Wu CY, David Wang HM, Huang HW, Chiu CC.

Oxid Med Cell Longev. 2016;2016:9128102. Epub 2016 Oct 24.


A Quinone-Containing Compound Enhances Camptothecin-Induced Apoptosis of Lung Cancer Through Modulating Endogenous ROS and ERK Signaling.

Chou HL, Fong Y, Wei CK, Tsai EM, Chen JY, Chang WT, Wu CY, Huang HW, Chiu CC.

Arch Immunol Ther Exp (Warsz). 2017 Jun;65(3):241-252. doi: 10.1007/s00005-016-0424-8. Epub 2016 Sep 27.


Butanol-Partitioned Extraction from Aqueous Extract of Gracilaria tenuistipitata Inhibits Cell Proliferation of Oral Cancer Cells Involving Apoptosis and Oxidative Stress.

Yeh CC, Li KT, Tang JY, Wang HR, Liu JR, Huang HW, Chang FR, Tsai CE, Lo IW, Huang MY, Chang HW.

DNA Cell Biol. 2016 May;35(5):210-6. doi: 10.1089/dna.2015.3044. Epub 2016 Jan 26.


Antiproliferation of Cryptocarya concinna-derived cryptocaryone against oral cancer cells involving apoptosis, oxidative stress, and DNA damage.

Chang HS, Tang JY, Yen CY, Huang HW, Wu CY, Chung YA, Wang HR, Chen IS, Huang MY, Chang HW.

BMC Complement Altern Med. 2016 Mar 8;16:94. doi: 10.1186/s12906-016-1073-5.


Synergistic anti-oral cancer effects of UVC and methanolic extracts of Cryptocarya concinna roots via apoptosis, oxidative stress and DNA damage.

Chang HW, Tang JY, Yen CY, Chang HS, Huang HW, Chung YA, Chen IS, Huang MY.

Int J Radiat Biol. 2016 May;92(5):263-72. doi: 10.3109/09553002.2016.1145753. Epub 2016 Feb 18.


DNA methylation, histone acetylation and methylation of epigenetic modifications as a therapeutic approach for cancers.

Yen CY, Huang HW, Shu CW, Hou MF, Yuan SS, Wang HR, Chang YT, Farooqi AA, Tang JY, Chang HW.

Cancer Lett. 2016 Apr 10;373(2):185-92. doi: 10.1016/j.canlet.2016.01.036. Epub 2016 Jan 22. Review.


Assessment of branch pulmonary artery stenosis in children after repair of tetralogy of Fallot using lung perfusion scintigraphy comparison with echocardiography.

Chien KJ, Huang HW, Huang TC, Lee CL, Weng KP, Lin CC, Shieh PC, Wu MT, Hsieh KS.

Ann Nucl Med. 2016 Jan;30(1):49-59.


Natural Products Mediated Regulation of Oxidative Stress and DNA Damage in Ultraviolet Exposed Skin Cells.

Farooqi AA, Li RN, Huang HW, Ismail M, Yuan SS, Wang HM, Liu JR, Tang JY, Chang HW.

Curr Pharm Biotechnol. 2015;16(12):1078-84.


Alternative Splicing, DNA Damage and Modulating Drugs in Radiation Therapy for Cancer.

Tang JY, Li RN, Chen PH, Huang HW, Hou MF, Chang HW.

Anticancer Agents Med Chem. 2015;15(6):674-80. Review.


Concentration effects of grape seed extracts in anti-oral cancer cells involving differential apoptosis, oxidative stress, and DNA damage.

Yen CY, Hou MF, Yang ZW, Tang JY, Li KT, Huang HW, Huang YH, Lee SY, Fu TF, Hsieh CY, Chen BH, Chang HW.

BMC Complement Altern Med. 2015 Mar 29;15:94. doi: 10.1186/s12906-015-0621-8.

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