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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1930 1
1931 2
1942 1
1943 2
1945 9
1947 1
1948 1
1949 5
1950 1
1952 1
1959 3
1960 1
1962 3
1963 2
1964 1
1965 1
1967 4
1968 1
1969 1
1970 1
1971 4
1972 5
1973 4
1974 7
1975 3
1976 8
1977 5
1978 8
1979 9
1980 16
1981 9
1982 16
1983 15
1984 28
1985 27
1986 109
1987 127
1988 157
1989 175
1990 165
1991 192
1992 220
1993 223
1994 253
1995 226
1996 380
1997 474
1998 459
1999 570
2000 618
2001 683
2002 587
2003 703
2004 564
2005 671
2006 829
2007 915
2008 1107
2009 1185
2010 1327
2011 1411
2012 1568
2013 1849
2014 2276
2015 2546
2016 2659
2017 2784
2018 3094
2019 3247
2020 3982
2021 4351
2022 4838
2023 4642
2024 1511

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48,839 results

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The following term was not found in PubMed: 20Xia
Page 1
Gut microbiota remodeling: A promising therapeutic strategy to confront hyperuricemia and gout.
Wang Z, Li Y, Liao W, Huang J, Liu Y, Li Z, Tang J. Wang Z, et al. Front Cell Infect Microbiol. 2022 Aug 10;12:935723. doi: 10.3389/fcimb.2022.935723. eCollection 2022. Front Cell Infect Microbiol. 2022. PMID: 36034697 Free PMC article. Review.
The incidence of hyperuricemia (HUA) and gout continuously increases and has become a major public health problem. ...Structural changes or imbalance in the gut microbiota could cause metabolic disorders and participate in the synthesis of purine-metabolizing enzymes and t …
The incidence of hyperuricemia (HUA) and gout continuously increases and has become a major public health problem. ...Structural chan …
Rui-Hua Xu.
[No authors listed] [No authors listed] Cell Rep Med. 2022 Apr 19;3(4):100618. doi: 10.1016/j.xcrm.2022.100618. eCollection 2022 Apr 19. Cell Rep Med. 2022. PMID: 36090529 Free PMC article.
Rui-Hua Xu completed the REGOTORI trial that showed a novel combination regimen, regorafenib plus toripalimab, improved the efficacy and survival of refractory metastatic colorectal cancer, and found high-abundance Fusobacterium negatively predicted response and survival. …
Rui-Hua Xu completed the REGOTORI trial that showed a novel combination regimen, regorafenib plus toripalimab, improved the efficacy …
The gut microbiota as a target to control hyperuricemia pathogenesis: Potential mechanisms and therapeutic strategies.
Wang J, Chen Y, Zhong H, Chen F, Regenstein J, Hu X, Cai L, Feng F. Wang J, et al. Crit Rev Food Sci Nutr. 2022;62(14):3979-3989. doi: 10.1080/10408398.2021.1874287. Epub 2021 Jan 22. Crit Rev Food Sci Nutr. 2022. PMID: 33480266 Review.
Hyperuricemia (HUA) is a metabolic disorder caused by abnormal uric acid (UA) metabolism, which is a complex physiological process involving multiple organs (liver, kidney, and intestine). ...With our growing knowledge of the effects of gut microorganisms on health, the gu …
Hyperuricemia (HUA) is a metabolic disorder caused by abnormal uric acid (UA) metabolism, which is a complex physiological process in …
Hua Sheng.
[No authors listed] [No authors listed] Angew Chem Int Ed Engl. 2023 Mar 20;62(13):e202301138. doi: 10.1002/anie.202301138. Epub 2023 Feb 2. Angew Chem Int Ed Engl. 2023. PMID: 36727936
"A turning point in my career was when I started to learn how to use and build an in situ FTIR spectroscopy system in the second year of my PhD, and now, the mechanistic elucidation of interfacial photocatalytic reactions via in situ spectroscopy is the most critical part in my r …
"A turning point in my career was when I started to learn how to use and build an in situ FTIR spectroscopy system in the second year of my …
High uric acid induces liver fat accumulation via ROS/JNK/AP-1 signaling.
Xie D, Zhao H, Lu J, He F, Liu W, Yu W, Wang Q, Hisatome I, Yamamoto T, Koyama H, Cheng J. Xie D, et al. Am J Physiol Endocrinol Metab. 2021 Jun 1;320(6):E1032-E1043. doi: 10.1152/ajpendo.00518.2020. Epub 2021 Apr 26. Am J Physiol Endocrinol Metab. 2021. PMID: 33900847 Free article.
HUA activated AP-1 to upregulate lipogenic gene expression via JNK activation. In addition, HUA caused mitochondrial dysfunction and reactive oxygen species production. ...
HUA activated AP-1 to upregulate lipogenic gene expression via JNK activation. In addition, HUA caused mitochondrial dysfuncti
Excess Uric Acid Induces Gouty Nephropathy Through Crystal Formation: A Review of Recent Insights.
Mei Y, Dong B, Geng Z, Xu L. Mei Y, et al. Front Endocrinol (Lausanne). 2022 Jul 14;13:911968. doi: 10.3389/fendo.2022.911968. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 35909538 Free PMC article. Review.
Uric acid (UA) is the final product of purine metabolism in the human body, and impaired purine metabolism can increase the uric acid in serum, finally resulting in hyperuricemia (HUA). Current evidences suggest that urates might have antioxidant properties under certain c …
Uric acid (UA) is the final product of purine metabolism in the human body, and impaired purine metabolism can increase the uric acid in ser …
High Level of Uric Acid Promotes Atherosclerosis by Targeting NRF2-Mediated Autophagy Dysfunction and Ferroptosis.
Yu W, Liu W, Xie D, Wang Q, Xu C, Zhao H, Lv J, He F, Chen B, Yamamoto T, Koyama H, Cheng J. Yu W, et al. Oxid Med Cell Longev. 2022 Apr 18;2022:9304383. doi: 10.1155/2022/9304383. eCollection 2022. Oxid Med Cell Longev. 2022. PMID: 35480874 Free PMC article.
Mechanistically, HUA significantly inhibited autophagy and the protein level of the NRF2/SLC7A11/GPX4 signaling pathway. ...Moreover, an NRF2 inducer (tertbutyl hydroquinone (TBHQ)) and autophagy activator (rapamycin (RAPA)) could reverse the inhibitory effect of HUA
Mechanistically, HUA significantly inhibited autophagy and the protein level of the NRF2/SLC7A11/GPX4 signaling pathway. ...Moreover, …
Hyperuricemia: A key contributor to endothelial dysfunction in cardiovascular diseases.
Wei X, Zhang M, Huang S, Lan X, Zheng J, Luo H, He Y, Lei W. Wei X, et al. FASEB J. 2023 Jul;37(7):e23012. doi: 10.1096/fj.202300393R. FASEB J. 2023. PMID: 37272854 Review.
We additionally discuss intervention strategies for HUA-induced ED and the paradoxical roles of UA in endothelial function. ...However, the treatment strategies (in addition to urate-lowering therapy) for increasing endothelial function are limited because the majority of …
We additionally discuss intervention strategies for HUA-induced ED and the paradoxical roles of UA in endothelial function. ...Howeve …
Alteration of Gut Microbiome and Correlated Amino Acid Metabolism Contribute to Hyperuricemia and Th17-Driven Inflammation in Uox-KO Mice.
Song S, Lou Y, Mao Y, Wen X, Fan M, He Z, Shen Y, Wen C, Shao T. Song S, et al. Front Immunol. 2022 Feb 7;13:804306. doi: 10.3389/fimmu.2022.804306. eCollection 2022. Front Immunol. 2022. PMID: 35197978 Free PMC article.
Although gut dysbiosis had been demonstrated to be an important factor affecting hyperuricemia (HUA) and gout, little is known for its potential mechanistic connections. ...Remodeling the gut microbiota is a promising strategy to combat HUA and gout....
Although gut dysbiosis had been demonstrated to be an important factor affecting hyperuricemia (HUA) and gout, little is known for it …
Lactobacillus paracasei X11 Ameliorates Hyperuricemia and Modulates Gut Microbiota in Mice.
Cao J, Liu Q, Hao H, Bu Y, Tian X, Wang T, Yi H. Cao J, et al. Front Immunol. 2022 Jul 6;13:940228. doi: 10.3389/fimmu.2022.940228. eCollection 2022. Front Immunol. 2022. PMID: 35874662 Free PMC article.
Hyperuricemia (HUA) is the presence of excessive uric acid (UA) in blood, which leads to an increased risk of chronic kidney disease and gout. Probiotics have the potential effect of alleviating HUA. The purpose of this study was to screen probiotics with UA-lowerin …
Hyperuricemia (HUA) is the presence of excessive uric acid (UA) in blood, which leads to an increased risk of chronic kidney disease …
48,839 results
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