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Items: 1 to 20 of 177


Novel benzoyl thioureido benzene sulfonamides as highly potent and selective inhibitors of carbonic anhydrase IX: optimization and bioactive studies.

Liu L, Wang W, Huang J, Zhao Z, Li H, Xu Y.

Medchemcomm. 2018 Nov 9;9(12):2100-2105. doi: 10.1039/c8md00392k. eCollection 2018 Dec 1.


Exploring Spatial Influence of Remotely Sensed PM2.5 Concentration Using a Developed Deep Convolutional Neural Network Model.

Li J, Jin M, Li H.

Int J Environ Res Public Health. 2019 Feb 4;16(3). pii: E454. doi: 10.3390/ijerph16030454.


Indispensable role of the Ubiquitin-fold modifier 1-specific E3 ligase in maintaining intestinal homeostasis and controlling gut inflammation.

Cai Y, Zhu G, Liu S, Pan Z, Quintero M, Poole CJ, Lu C, Zhu H, Islam B, Riggelen JV, Browning D, Liu K, Blumberg R, Singh N, Li H.

Cell Discov. 2019 Jan 29;5:7. doi: 10.1038/s41421-018-0070-x. eCollection 2019.


Transcriptome profiling reveals the role of ZBTB38 knock-down in human neuroblastoma.

Chen J, Xing C, Yan L, Wang Y, Wang H, Zhang Z, Yu D, Li J, Li H, Li J, Cai Y.

PeerJ. 2019 Jan 24;7:e6352. doi: 10.7717/peerj.6352. eCollection 2019.


Discovery of a Natural-Product-Derived Preclinical Candidate for Once-Weekly Treatment of Type 2 Diabetes.

Li S, Qin C, Cui S, Xu H, Wu F, Wang J, Su M, Fang X, Li D, Jiao Q, Zhang M, Xia C, Zhu L, Wang R, Li J, Jiang H, Zhao Z, Li J, Li H.

J Med Chem. 2019 Feb 13. doi: 10.1021/acs.jmedchem.8b01491. [Epub ahead of print]


A diversity-oriented rhodamine library for wide-spectrum bactericidal agents with low inducible resistance against resistant pathogens.

Luo X, Qian L, Xiao Y, Tang Y, Zhao Y, Wang X, Gu L, Lei Z, Bao J, Wu J, He T, Hu F, Zheng J, Li H, Zhu W, Shao L, Dong X, Chen D, Qian X, Yang Y.

Nat Commun. 2019 Jan 16;10(1):258. doi: 10.1038/s41467-018-08241-3.


eSHAFTS: Integrated and graphical drug design software based on 3D molecular similarity.

He G, Song Y, Wei W, Wang X, Lu X, Li H.

J Comput Chem. 2019 Mar 5;40(6):826-838. doi: 10.1002/jcc.25769.


A potential role for SMAD9 in goose follicular selection through regulation of mRNA levels of luteinizing hormone receptor.

Yu D, Zhang L, Wang H, Chen F, Chen J, Zhang Z, Li J, Xing C, Li H, Li J, Cai Y.

Theriogenology. 2018 Nov 22. pii: S0093-691X(18)31081-1. doi: 10.1016/j.theriogenology.2018.11.022. [Epub ahead of print]


Intracellular reduction in ATP levels contributes to CYT997-induced suppression of metastasis of head and neck squamous carcinoma.

Zhao X, Lang L, He L, Gao L, Chyan D, Xiong Y, Li H, Peng H, Teng Y.

J Cell Mol Med. 2019 Feb;23(2):1174-1182. doi: 10.1111/jcmm.14017. Epub 2018 Nov 18.


Ufm1-Specific Ligase Ufl1 Regulates Endoplasmic Reticulum Homeostasis and Protects Against Heart Failure.

Li J, Yue G, Ma W, Zhang A, Zou J, Cai Y, Tang X, Wang J, Liu J, Li H, Su H.

Circ Heart Fail. 2018 Oct;11(10):e004917. doi: 10.1161/CIRCHEARTFAILURE.118.004917.


Switchable Fluorophores for Single-Molecule Localization Microscopy.

Li H, Vaughan JC.

Chem Rev. 2018 Sep 26;118(18):9412-9454. doi: 10.1021/acs.chemrev.7b00767. Epub 2018 Sep 17.


LOX inhibitor HOEC interfered arachidonic acid metabolic flux in collagen-induced arthritis rats.

Yang W, Wang X, Xu L, Li H, Wang R.

Am J Transl Res. 2018 Aug 15;10(8):2542-2554. eCollection 2018.


Multi-Body Interactions in Molecular Docking Program Devised with Key Water Molecules in Protein Binding Sites.

Xiao W, Wang D, Shen Z, Li S, Li H.

Molecules. 2018 Sep 11;23(9). pii: E2321. doi: 10.3390/molecules23092321.


Discovery and biological evaluation of N5-substituted 6,7-dioxo-6,7-dihydropteridine derivatives as potent Bruton's tyrosine kinase inhibitors.

Chen H, Song P, Diao Y, Hao Y, Dou D, Wang W, Fang X, Wang Y, Zhao Z, Ding J, Li H, Xie H, Xu Y.

Medchemcomm. 2018 Mar 13;9(4):697-704. doi: 10.1039/c8md00019k. eCollection 2018 Apr 1.


ZBTB38, a novel regulator of autophagy initiation targeted by RB1CC1/FIP200 in spinal cord injury.

Chen J, Yan L, Wang H, Zhang Z, Yu D, Xing C, Li J, Li H, Li J, Cai Y.

Gene. 2018 Dec 15;678:8-16. doi: 10.1016/j.gene.2018.07.073. Epub 2018 Aug 1.


Quercetin-3-methyl ether inhibits esophageal carcinogenesis by targeting the AKT/mTOR/p70S6K and MAPK pathways.

Zhao S, Jiang Y, Zhao J, Li H, Yin X, Wang Y, Xie Y, Chen X, Lu J, Dong Z, Liu K.

Mol Carcinog. 2018 Nov;57(11):1540-1552. doi: 10.1002/mc.22876. Epub 2018 Aug 28.


Natural and synthetic flavonoids, novel blockers of the volume-regulated anion channels, inhibit endothelial cell proliferation.

Xue Y, Li H, Zhang Y, Han X, Zhang G, Li W, Zhang H, Lin Y, Chen P, Sun X, Liu Y, Chu L, Zhang J, Zhang M, Zhang X.

Pflugers Arch. 2018 Oct;470(10):1473-1483. doi: 10.1007/s00424-018-2170-8. Epub 2018 Jun 30.


Design, Synthesis, and Biological Evaluation of Pyrimido[4,5- d]pyrimidine-2,4(1 H,3 H)-diones as Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors against L858R/T790M Resistance Mutation.

Hao Y, Lyu J, Qu R, Tong Y, Sun D, Feng F, Tong L, Yang T, Zhao Z, Zhu L, Ding J, Xu Y, Xie H, Li H.

J Med Chem. 2018 Jul 12;61(13):5609-5622. doi: 10.1021/acs.jmedchem.8b00346. Epub 2018 Jun 25.


Synthesis, Design, and StructureâğActivity Relationship of the Pyrimidone Derivatives as Novel Selective Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase.

Xu L, Li W, Diao Y, Sun H, Li H, Zhu L, Zhou H, Zhao Z.

Molecules. 2018 May 24;23(6). pii: E1254. doi: 10.3390/molecules23061254.


Modulation the crosstalk between tumor-associated macrophages and non-small cell lung cancer to inhibit tumor migration and invasion by ginsenoside Rh2.

Li H, Huang N, Zhu W, Wu J, Yang X, Teng W, Tian J, Fang Z, Luo Y, Chen M, Li Y.

BMC Cancer. 2018 May 22;18(1):579. doi: 10.1186/s12885-018-4299-4.

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