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Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):3094-3100. doi: 10.1080/21691401.2019.1637883.

Progress of titanium strut for cervical reconstruction with nano-graphene oxide loaded hydroxyapatite/polyamide composite and interbody fusion after corpectomy with anterior plate fixation.

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a Department of Neurosurgery, Luoyang Central Hospital Affiliated to Zhengzhou University , Luoyang , China.
b Department of Neurosurgery, Qilu Hospital, Shandong University , Qingdao , China.
c Department of Neurosurgery, Weifang brain Hospital , WeiFang , China.
d Department of Neurosurgery, Jinan Fourth People's Hospital , Jinan , China.
e Department of Orthopedic Surgery, First Affiliated Hospital of Zhengzhou University , Zhengzhou , China.


To evaluate the long-term biological and clinical results of anterior cervical corpectomy and fusion (ACCF) with a synthesized nano-graphene oxide (nano-GO) loaded hydroxyapatite/polyamide (HAp/PA) strut in the implantation treatment of cervical reconstruction. Bio-ceramic Hydroxyapatite (HAp) combined with suitable polymer matrix is one of the furthermost naturally occurring biomaterial form for hard tissues and dental regeneration therapies due to their bone-like chemical compositional structure and biocompatibility similarity to native bone of the human body. In the present investigation, the development of nano-GO loaded HAp/PA composite strut for anterior cervical reform and fusion properties after corpectomy is studied. Forty patients who suffered from first or second level ACCF, treated with nano-GO loaded HAp/PA strut, were investigated. At final follow-up period, the fusion rate was 99%, and the subsidence value of the prepared strut was 5%. The results of cell viability and proliferation analyses indicated that the prepared nanocomposites did not exhibit non-cytotoxicity with the human cells. In summary, the satisfactory consequences in this research work designated that the nano-GO loaded HAp/PA strut was an active implant in the treatment of cervical reconstruction. Furthermore, the osteoconductive and osseointegration properties of the prepared struts need to be analyzed and optimized for future bio-medical usages.


Hydroxyapatite; anterior plate; bone fusion; cervical reconstruction; graphene oxide

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