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Items: 1 to 20 of 56


α-Synuclein strains target distinct brain regions and cell types.

Lau A, So RWL, Lau HHC, Sang JC, Ruiz-Riquelme A, Fleck SC, Stuart E, Menon S, Visanji NP, Meisl G, Faidi R, Marano MM, Schmitt-Ulms C, Wang Z, Fraser PE, Tandon A, Hyman BT, Wille H, Ingelsson M, Klenerman D, Watts JC.

Nat Neurosci. 2019 Dec 2. doi: 10.1038/s41593-019-0541-x. [Epub ahead of print]


Full atomistic model of prion structure and conversion.

Spagnolli G, Rigoli M, Orioli S, Sevillano AM, Faccioli P, Wille H, Biasini E, Requena JR.

PLoS Pathog. 2019 Jul 11;15(7):e1007864. doi: 10.1371/journal.ppat.1007864. eCollection 2019 Jul.


The human brain somatostatin interactome: SST binds selectively to P-type family ATPases.

Solarski M, Williams D, Mehrabian M, Wang H, Wille H, Schmitt-Ulms G.

PLoS One. 2019 May 28;14(5):e0217392. doi: 10.1371/journal.pone.0217392. eCollection 2019.


The prion 2018 round tables (I): the structure of PrPSc.

Baskakov IV, Caughey B, Requena JR, Sevillano AM, Surewicz WK, Wille H.

Prion. 2019 Jan;13(1):46-52. doi: 10.1080/19336896.2019.1569450.


Comparing the Folds of Prions and Other Pathogenic Amyloids.

Flores-Fernández JM, Rathod V, Wille H.

Pathogens. 2018 May 4;7(2). pii: E50. doi: 10.3390/pathogens7020050. Review.


The Structure of PrPSc Prions.

Wille H, Requena JR.

Pathogens. 2018 Feb 7;7(1). pii: E20. doi: 10.3390/pathogens7010020. Review.


A novel Gerstmann-Sträussler-Scheinker disease mutation defines a precursor for amyloidogenic 8 kDa PrP fragments and reveals N-terminal structural changes shared by other GSS alleles.

Mercer RCC, Daude N, Dorosh L, Fu ZL, Mays CE, Gapeshina H, Wohlgemuth SL, Acevedo-Morantes CY, Yang J, Cashman NR, Coulthart MB, Pearson DM, Joseph JT, Wille H, Safar JG, Jansen GH, Stepanova M, Sykes BD, Westaway D.

PLoS Pathog. 2018 Jan 16;14(1):e1006826. doi: 10.1371/journal.ppat.1006826. eCollection 2018 Jan.


Somatostatin in Alzheimer's disease: A new Role for an Old Player.

Solarski M, Wang H, Wille H, Schmitt-Ulms G.

Prion. 2018 Jan 2;12(1):1-8. doi: 10.1080/19336896.2017.1405207. Epub 2018 Jan 31.


The CNS in inbred transgenic models of 4-repeat Tauopathy develops consistent tau seeding capacity yet focal and diverse patterns of protein deposition.

Eskandari-Sedighi G, Daude N, Gapeshina H, Sanders DW, Kamali-Jamil R, Yang J, Shi B, Wille H, Ghetti B, Diamond MI, Janus C, Westaway D.

Mol Neurodegener. 2017 Oct 4;12(1):72. doi: 10.1186/s13024-017-0215-7.


The Structure of the Infectious Prion Protein and Its Propagation.

Requena JR, Wille H.

Prog Mol Biol Transl Sci. 2017;150:341-359. doi: 10.1016/bs.pmbts.2017.06.009. Epub 2017 Jul 31. Review.


Destabilizing polymorphism in cervid prion protein hydrophobic core determines prion conformation and conversion efficiency.

Hannaoui S, Amidian S, Cheng YC, Duque Velásquez C, Dorosh L, Law S, Telling G, Stepanova M, McKenzie D, Wille H, Gilch S.

PLoS Pathog. 2017 Aug 11;13(8):e1006553. doi: 10.1371/journal.ppat.1006553. eCollection 2017 Aug.


Somatostatin binds to the human amyloid β peptide and favors the formation of distinct oligomers.

Wang H, Muiznieks LD, Ghosh P, Williams D, Solarski M, Fang A, Ruiz-Riquelme A, Pomès R, Watts JC, Chakrabartty A, Wille H, Sharpe S, Schmitt-Ulms G.

Elife. 2017 Jun 26;6. pii: e28401. doi: 10.7554/eLife.28401.


Bioluminescence Imaging of Neuroinflammation in Transgenic Mice After Peripheral Inoculation of Alpha-Synuclein Fibrils.

Breid S, Bernis ME, Tachu JB, Garza MC, Wille H, Tamgüney G.

J Vis Exp. 2017 Apr 13;(122). doi: 10.3791/55503.


Elucidating the structure of an infectious protein.

Zweckstetter M, Requena JR, Wille H.

PLoS Pathog. 2017 Apr 13;13(4):e1006229. doi: 10.1371/journal.ppat.1006229. eCollection 2017 Apr. Review. No abstract available.


An easy method for bacterial expression and purification of wild-type and mutant superoxide dismutase 1 (SOD1).

Tachu BJ, Wüsten KA, Garza MC, Wille H, Tamgüney G.

Protein Expr Purif. 2017 Jun;134:63-71. doi: 10.1016/j.pep.2017.04.001. Epub 2017 Apr 3. No abstract available.


The Structural Architecture of an Infectious Mammalian Prion Using Electron Cryomicroscopy.

Vázquez-Fernández E, Vos MR, Afanasyev P, Cebey L, Sevillano AM, Vidal E, Rosa I, Renault L, Ramos A, Peters PJ, Fernández JJ, van Heel M, Young HS, Requena JR, Wille H.

PLoS Pathog. 2016 Sep 8;12(9):e1005835. doi: 10.1371/journal.ppat.1005835. eCollection 2016 Sep.


Neuroinvasion of α-Synuclein Prionoids after Intraperitoneal and Intraglossal Inoculation.

Breid S, Bernis ME, Babila JT, Garza MC, Wille H, Tamgüney G.

J Virol. 2016 Sep 29;90(20):9182-93. doi: 10.1128/JVI.01399-16. Print 2016 Oct 15.


A Neuronal Culture System to Detect Prion Synaptotoxicity.

Fang C, Imberdis T, Garza MC, Wille H, Harris DA.

PLoS Pathog. 2016 May 26;12(5):e1005623. doi: 10.1371/journal.ppat.1005623. eCollection 2016 May.


Secretory pathway retention of mutant prion protein induces p38-MAPK activation and lethal disease in mice.

Puig B, Altmeppen HC, Ulbrich S, Linsenmeier L, Krasemann S, Chakroun K, Acevedo-Morantes CY, Wille H, Tatzelt J, Glatzel M.

Sci Rep. 2016 Apr 27;6:24970. doi: 10.1038/srep24970.


The Detection of Infectious Prions: In Vitro Conversion Assays Change the (Folding) Landscape.

Wille H.

J Mol Diagn. 2016 May;18(3):329-330. doi: 10.1016/j.jmoldx.2016.03.001. Epub 2016 Mar 25.


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