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Items: 1 to 20 of 107


The Antibiotic Bacitracin Protects Human Intestinal Epithelial Cells and Stem Cell-Derived Intestinal Organoids from Clostridium difficile Toxin TcdB.

Zhu Z, Schnell L, Müller B, Müller M, Papatheodorou P, Barth H.

Stem Cells Int. 2019 Aug 5;2019:4149762. doi: 10.1155/2019/4149762. eCollection 2019.


Supramolecular Toxin Complexes for Targeted Pharmacological Modulation of Polymorphonuclear Leukocyte Functions.

Heck AJ, Ostertag T, Schnell L, Fischer S, Agrawalla BK, Winterwerber P, Wirsching E, Fauler M, Frick M, Kuan SL, Weil T, Barth H.

Adv Healthc Mater. 2019 Sep;8(17):e1900665. doi: 10.1002/adhm.201900665. Epub 2019 Jul 18.


Revisiting an old antibiotic: bacitracin neutralizes binary bacterial toxins and protects cells from intoxication.

Schnell L, Felix I, Müller B, Sadi M, von Bank F, Papatheodorou P, Popoff MR, Aktories K, Waltenberger E, Benz R, Weichbrodt C, Fauler M, Frick M, Barth H.

FASEB J. 2019 Apr;33(4):5755-5771. doi: 10.1096/fj.201802453R. Epub 2019 Jan 30.


Prognostic impact of polypharmacy and drug interactions in patients with advanced cancer.

Hoemme A, Barth H, Haschke M, Krähenbühl S, Strasser F, Lehner C, von Kameke A, Wälti T, Thürlimann B, Früh M, Driessen C, Joerger M.

Cancer Chemother Pharmacol. 2019 Apr;83(4):763-774. doi: 10.1007/s00280-019-03783-9. Epub 2019 Jan 25.


Cyclic Changes in the Amide Bands Within Escherichia coli Biofilms Monitored Using Real-Time Infrared Attenuated Total Reflection Spectroscopy (IR-ATR).

Stenclova P, Freisinger S, Barth H, Kromka A, Mizaikoff B.

Appl Spectrosc. 2019 Apr;73(4):424-432. doi: 10.1177/0003702819829081. Epub 2019 Feb 20.


Combined Pharmacological Inhibition of Cyclophilins, FK506-Binding Proteins, Hsp90, and Hsp70 Protects Cells From Clostridium botulinum C2 Toxin.

Ernst K, Kling C, Landenberger M, Barth H.

Front Pharmacol. 2018 Nov 13;9:1287. doi: 10.3389/fphar.2018.01287. eCollection 2018.


Autonomous Ultrafast Self-Healing Hydrogels by pH-Responsive Functional Nanofiber Gelators as Cell Matrices.

Gačanin J, Hedrich J, Sieste S, Glaßer G, Lieberwirth I, Schilling C, Fischer S, Barth H, Knöll B, Synatschke CV, Weil T.

Adv Mater. 2019 Jan;31(2):e1805044. doi: 10.1002/adma.201805044. Epub 2018 Nov 9.


Primary resistance of human patients to botulinum neurotoxins A and B.

Pirazzini M, Carle S, Barth H, Rossetto O, Montecucco C.

Ann Clin Transl Neurol. 2018 Jul 17;5(8):971-975. doi: 10.1002/acn3.586. eCollection 2018 Aug.


Boosting Antitumor Drug Efficacy with Chemically Engineered Multidomain Proteins.

Kuan SL, Fischer S, Hafner S, Wang T, Syrovets T, Liu W, Tokura Y, Ng DYW, Riegger A, Förtsch C, Jäger D, Barth TFE, Simmet T, Barth H, Weil T.

Adv Sci (Weinh). 2018 Jun 14;5(8):1701036. doi: 10.1002/advs.201701036. eCollection 2018 Aug.


Toxins of Locus of Enterocyte Effacement-Negative Shiga Toxin-Producing Escherichia coli.

Krause M, Barth H, Schmidt H.

Toxins (Basel). 2018 Jun 14;10(6). pii: E241. doi: 10.3390/toxins10060241. Review.


Human Serum Albumin Is an Essential Component of the Host Defense Mechanism Against Clostridium difficile Intoxication.

di Masi A, Leboffe L, Polticelli F, Tonon F, Zennaro C, Caterino M, Stano P, Fischer S, Hägele M, Müller M, Kleger A, Papatheodorou P, Nocca G, Arcovito A, Gori A, Ruoppolo M, Barth H, Petrosillo N, Ascenzi P, Di Bella S.

J Infect Dis. 2018 Sep 22;218(9):1424-1435. doi: 10.1093/infdis/jiy338.


Pharmacological Cyclophilin Inhibitors Prevent Intoxication of Mammalian Cells with Bordetella pertussis Toxin.

Ernst K, Eberhardt N, Mittler AK, Sonnabend M, Anastasia A, Freisinger S, Schiene-Fischer C, Malešević M, Barth H.

Toxins (Basel). 2018 May 1;10(5). pii: E181. doi: 10.3390/toxins10050181.


Human alpha-defensin-1 protects cells from intoxication with Clostridium perfringens iota toxin.

Fischer S, Popoff MR, Barth H.

Pathog Dis. 2018 Mar 1;76(2). doi: 10.1093/femspd/fty022.


Cellular Uptake and Mode-of-Action of Clostridium difficile Toxins.

Papatheodorou P, Barth H, Minton N, Aktories K.

Adv Exp Med Biol. 2018;1050:77-96. doi: 10.1007/978-3-319-72799-8_6. Review.


High Conservation of Tetanus and Botulinum Neurotoxins Cleavage Sites on Human SNARE Proteins Suggests That These Pathogens Exerted Little or No Evolutionary Pressure on Humans.

Carle S, Pirazzini M, Rossetto O, Barth H, Montecucco C.

Toxins (Basel). 2017 Dec 19;9(12). pii: E404. doi: 10.3390/toxins9120404.


Directing intracellular supramolecular assembly with N-heteroaromatic quaterthiophene analogues.

Ng DYW, Vill R, Wu Y, Koynov K, Tokura Y, Liu W, Sihler S, Kreyes A, Ritz S, Barth H, Ziener U, Weil T.

Nat Commun. 2017 Nov 29;8(1):1850. doi: 10.1038/s41467-017-02020-2.


Rho-inhibiting C2IN-C3 fusion toxin inhibits chemotactic recruitment of human monocytes ex vivo and in mice in vivo.

Martin T, Möglich A, Felix I, Förtsch C, Rittlinger A, Palmer A, Denk S, Schneider J, Notbohm L, Vogel M, Geiger H, Paschke S, Huber-Lang M, Barth H.

Arch Toxicol. 2018 Jan;92(1):323-336. doi: 10.1007/s00204-017-2058-y. Epub 2017 Sep 18.


Spatiotemporally Controlled Release of Rho-Inhibiting C3 Toxin from a Protein-DNA Hybrid Hydrogel for Targeted Inhibition of Osteoclast Formation and Activity.

Gačanin J, Kovtun A, Fischer S, Schwager V, Quambusch J, Kuan SL, Liu W, Boldt F, Li C, Yang Z, Liu D, Wu Y, Weil T, Barth H, Ignatius A.

Adv Healthc Mater. 2017 Nov;6(21). doi: 10.1002/adhm.201700392. Epub 2017 Jul 31.


Toxin Transport by A-B Type of Toxins in Eukaryotic Target Cells and Its Inhibition by Positively Charged Heterocyclic Molecules.

Benz R, Barth H.

Curr Top Microbiol Immunol. 2017;406:229-256. doi: 10.1007/82_2017_17. Review.


Hsp70 facilitates trans-membrane transport of bacterial ADP-ribosylating toxins into the cytosol of mammalian cells.

Ernst K, Schmid J, Beck M, Hägele M, Hohwieler M, Hauff P, Ückert AK, Anastasia A, Fauler M, Jank T, Aktories K, Popoff MR, Schiene-Fischer C, Kleger A, Müller M, Frick M, Barth H.

Sci Rep. 2017 Jun 2;7(1):2724. doi: 10.1038/s41598-017-02882-y.

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