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Items: 1 to 20 of 38


Type II DNA Topoisomerases Cause Spontaneous Double-Strand Breaks in Genomic DNA.

Morimoto S, Tsuda M, Bunch H, Sasanuma H, Austin C, Takeda S.

Genes (Basel). 2019 Oct 30;10(11). pii: E868. doi: 10.3390/genes10110868. Review.


Processing of a single ribonucleotide embedded into DNA by human nucleotide excision repair and DNA polymerase η.

Sassa A, Tada H, Takeishi A, Harada K, Suzuki M, Tsuda M, Sasanuma H, Takeda S, Sugasawa K, Yasui M, Honma M, Ura K.

Sci Rep. 2019 Sep 26;9(1):13910. doi: 10.1038/s41598-019-50421-8.


Spatial Chromosome Folding and Active Transcription Drive DNA Fragility and Formation of Oncogenic MLL Translocations.

Gothe HJ, Bouwman BAM, Gusmao EG, Piccinno R, Petrosino G, Sayols S, Drechsel O, Minneker V, Josipovic N, Mizi A, Nielsen CF, Wagner EM, Takeda S, Sasanuma H, Hudson DF, Kindler T, Baranello L, Papantonis A, Crosetto N, Roukos V.

Mol Cell. 2019 Jul 25;75(2):267-283.e12. doi: 10.1016/j.molcel.2019.05.015. Epub 2019 Jun 12.


Srs2 helicase prevents the formation of toxic DNA damage during late prophase I of yeast meiosis.

Sasanuma H, Sakurai HSM, Furihata Y, Challa K, Palmer L, Gasser SM, Shinohara M, Shinohara A.

Chromosoma. 2019 Sep;128(3):453-471. doi: 10.1007/s00412-019-00709-5. Epub 2019 Jun 6.


PDIP38/PolDIP2 controls the DNA damage tolerance pathways by increasing the relative usage of translesion DNA synthesis over template switching.

Tsuda M, Ogawa S, Ooka M, Kobayashi K, Hirota K, Wakasugi M, Matsunaga T, Sakuma T, Yamamoto T, Chikuma S, Sasanuma H, Debatisse M, Doherty AJ, Fuchs RP, Takeda S.

PLoS One. 2019 Mar 6;14(3):e0213383. doi: 10.1371/journal.pone.0213383. eCollection 2019.


BRCA1 Haploinsufficiency Is Masked by RNF168-Mediated Chromatin Ubiquitylation.

Zong D, Adam S, Wang Y, Sasanuma H, Callén E, Murga M, Day A, Kruhlak MJ, Wong N, Munro M, Ray Chaudhuri A, Karim B, Xia B, Takeda S, Johnson N, Durocher D, Nussenzweig A.

Mol Cell. 2019 Mar 21;73(6):1267-1281.e7. doi: 10.1016/j.molcel.2018.12.010. Epub 2019 Jan 28.


SUMOylation of PCNA by PIAS1 and PIAS4 promotes template switch in the chicken and human B cell lines.

Mohiuddin M, Evans TJ, Rahman MM, Keka IS, Tsuda M, Sasanuma H, Takeda S.

Proc Natl Acad Sci U S A. 2018 Dec 11;115(50):12793-12798. doi: 10.1073/pnas.1716349115. Epub 2018 Nov 28.


BRCA1 ensures genome integrity by eliminating estrogen-induced pathological topoisomerase II-DNA complexes.

Sasanuma H, Tsuda M, Morimoto S, Saha LK, Rahman MM, Kiyooka Y, Fujiike H, Cherniack AD, Itou J, Callen Moreu E, Toi M, Nakada S, Tanaka H, Tsutsui K, Yamada S, Nussenzweig A, Takeda S.

Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10642-E10651. doi: 10.1073/pnas.1803177115. Epub 2018 Oct 23.


Differential micronucleus frequency in isogenic human cells deficient in DNA repair pathways is a valuable indicator for evaluating genotoxic agents and their genotoxic mechanisms.

Saha LK, Kim S, Kang H, Akter S, Choi K, Sakuma T, Yamamoto T, Sasanuma H, Hirota K, Nakamura J, Honma M, Takeda S, Dertinger S.

Environ Mol Mutagen. 2018 Jul;59(6):529-538. doi: 10.1002/em.22201. Epub 2018 May 15.


Disruption of Hif-1α enhances cytotoxic effects of metformin in murine squamous cell carcinoma.

Sanada Y, Sasanuma H, Takeda S, Tano K, Masunaga SI.

Int J Radiat Biol. 2018 Jan;94(1):88-96. doi: 10.1080/09553002.2018.1409443. Epub 2017 Dec 12.


Complementation of aprataxin deficiency by base excision repair enzymes in mitochondrial extracts.

Çaglayan M, Prasad R, Krasich R, Longley MJ, Kadoda K, Tsuda M, Sasanuma H, Takeda S, Tano K, Copeland WC, Wilson SH.

Nucleic Acids Res. 2017 Sep 29;45(17):10079-10088. doi: 10.1093/nar/gkx654.


Selective cytotoxicity of the anti-diabetic drug, metformin, in glucose-deprived chicken DT40 cells.

Kadoda K, Moriwaki T, Tsuda M, Sasanuma H, Ishiai M, Takata M, Ide H, Masunaga SI, Takeda S, Tano K.

PLoS One. 2017 Sep 19;12(9):e0185141. doi: 10.1371/journal.pone.0185141. eCollection 2017.


TDP1 is Critical for the Repair of DNA Breaks Induced by Sapacitabine, a Nucleoside also Targeting ATM- and BRCA-Deficient Tumors.

Al Abo M, Sasanuma H, Liu X, Rajapakse VN, Huang SY, Kiselev E, Takeda S, Plunkett W, Pommier Y.

Mol Cancer Ther. 2017 Nov;16(11):2543-2551. doi: 10.1158/1535-7163.MCT-17-0110. Epub 2017 Aug 11.


The dominant role of proofreading exonuclease activity of replicative polymerase ε in cellular tolerance to cytarabine (Ara-C).

Tsuda M, Terada K, Ooka M, Kobayashi K, Sasanuma H, Fujisawa R, Tsurimoto T, Yamamoto J, Iwai S, Kadoda K, Akagawa R, Huang SN, Pommier Y, Sale JE, Takeda S, Hirota K.

Oncotarget. 2017 May 16;8(20):33457-33474. doi: 10.18632/oncotarget.16508.


Cytotoxicity of Tirapazamine (3-Amino-1,2,4-benzotriazine-1,4-dioxide)-Induced DNA Damage in Chicken DT40 Cells.

Moriwaki T, Okamoto S, Sasanuma H, Nagasawa H, Takeda S, Masunaga SI, Tano K.

Chem Res Toxicol. 2017 Feb 20;30(2):699-704. doi: 10.1021/acs.chemrestox.6b00417. Epub 2016 Dec 27.


Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes.

Hoa NN, Shimizu T, Zhou ZW, Wang ZQ, Deshpande RA, Paull TT, Akter S, Tsuda M, Furuta R, Tsutsui K, Takeda S, Sasanuma H.

Mol Cell. 2016 Dec 1;64(5):1010. doi: 10.1016/j.molcel.2016.11.028. No abstract available.


Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes.

Hoa NN, Shimizu T, Zhou ZW, Wang ZQ, Deshpande RA, Paull TT, Akter S, Tsuda M, Furuta R, Tsutsui K, Takeda S, Sasanuma H.

Mol Cell. 2016 Nov 3;64(3):580-592. doi: 10.1016/j.molcel.2016.10.011. Erratum in: Mol Cell. 2016 Dec 1;64(5):1010.


Poor recognition of O6-isopropyl dG by MGMT triggers double strand break-mediated cell death and micronucleus induction in FANC-deficient cells.

Hashimoto K, Sharma V, Sasanuma H, Tian X, Takata M, Takeda S, Swenberg JA, Nakamura J.

Oncotarget. 2016 Sep 13;7(37):59795-59808. doi: 10.18632/oncotarget.10928.


The role of the Mre11-Rad50-Nbs1 complex in double-strand break repair-facts and myths.

Takeda S, Hoa NN, Sasanuma H.

J Radiat Res. 2016 Aug;57 Suppl 1:i25-i32. doi: 10.1093/jrr/rrw034. Epub 2016 Jun 15.


Deazaflavin Inhibitors of Tyrosyl-DNA Phosphodiesterase 2 (TDP2) Specific for the Human Enzyme and Active against Cellular TDP2.

Marchand C, Abdelmalak M, Kankanala J, Huang SY, Kiselev E, Fesen K, Kurahashi K, Sasanuma H, Takeda S, Aihara H, Wang Z, Pommier Y.

ACS Chem Biol. 2016 Jul 15;11(7):1925-33. doi: 10.1021/acschembio.5b01047. Epub 2016 May 11.


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