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Pioglitazone suppresses macrophage proliferation in apolipoprotein-E deficient mice by activating PPAR╬│.

Murakami-Nishida S, Matsumura T, Senokuchi T, Ishii N, Kinoshita H, Yamada S, Morita Y, Nishida S, Motoshima H, Kondo T, Komohara Y, Araki E.

Atherosclerosis. 2019 Jul;286:30-39. doi: 10.1016/j.atherosclerosis.2019.04.229. Epub 2019 May 3.


Mineralocorticoid Receptor May Regulate Glucose Homeostasis through the Induction of Interleukin-6 and Glucagon-Like peptide-1 in Pancreatic Islets.

Goto R, Kondo T, Ono K, Kitano S, Miyakawa N, Watanabe T, Sakaguchi M, Sato M, Igata M, Kawashima J, Motoshima H, Matsumura T, Shimoda S, Araki E.

J Clin Med. 2019 May 14;8(5). pii: E674. doi: 10.3390/jcm8050674.


Impact of hepatic HSP72 on insulin signaling.

Kitano S, Kondo T, Matsuyama R, Ono K, Goto R, Takaki Y, Hanatani S, Sakaguchi M, Igata M, Kawashima J, Motoshima H, Matsumura T, Kai H, Araki E.

Am J Physiol Endocrinol Metab. 2019 Feb 1;316(2):E305-E318. doi: 10.1152/ajpendo.00215.2018. Epub 2018 Dec 11.


Impacts of the 2016 Kumamoto Earthquake on glycemic control in patients with diabetes.

Kondo T, Miyakawa N, Motoshima H, Hanatani S, Ishii N, Igata M, Yoshinaga K, Kukidome D, Senokuchi T, Kawashima J, Furukawa N, Matsumura T, Araki E.

J Diabetes Investig. 2019 Mar;10(2):521-530. doi: 10.1111/jdi.12891. Epub 2018 Aug 1.


Inhibition of Local Macrophage Growth Ameliorates Focal Inflammation and Suppresses Atherosclerosis.

Yamada S, Senokuchi T, Matsumura T, Morita Y, Ishii N, Fukuda K, Murakami-Nishida S, Nishida S, Kawasaki S, Motoshima H, Furukawa N, Komohara Y, Fujiwara Y, Koga T, Yamagata K, Takeya M, Araki E.

Arterioscler Thromb Vasc Biol. 2018 May;38(5):994-1006. doi: 10.1161/ATVBAHA.117.310320. Epub 2018 Mar 1.


Identification of microRNA that represses IRS-1 expression in liver.

Ono K, Igata M, Kondo T, Kitano S, Takaki Y, Hanatani S, Sakaguchi M, Goto R, Senokuchi T, Kawashima J, Furukawa N, Motoshima H, Araki E.

PLoS One. 2018 Jan 24;13(1):e0191553. doi: 10.1371/journal.pone.0191553. eCollection 2018.


Low glucose induces mitochondrial reactive oxygen species via fatty acid oxidation in bovine aortic endothelial cells.

Kajihara N, Kukidome D, Sada K, Motoshima H, Furukawa N, Matsumura T, Nishikawa T, Araki E.

J Diabetes Investig. 2017 Nov;8(6):750-761. doi: 10.1111/jdi.12678. Epub 2017 May 24.


Acetate alters expression of genes involved in beige adipogenesis in 3T3-L1 cells and obese KK-Ay mice.

Hanatani S, Motoshima H, Takaki Y, Kawasaki S, Igata M, Matsumura T, Kondo T, Senokuchi T, Ishii N, Kawashima J, Kukidome D, Shimoda S, Nishikawa T, Araki E.

J Clin Biochem Nutr. 2016 Nov;59(3):207-214. Epub 2016 Sep 8.


Activation of heat shock response to treat obese subjects with type 2 diabetes: a prospective, frequency-escalating, randomized, open-label, triple-arm trial.

Kondo T, Goto R, Ono K, Kitano S, Suico MA, Sato M, Igata M, Kawashima J, Motoshima H, Matsumura T, Kai H, Araki E.

Sci Rep. 2016 Oct 19;6:35690. doi: 10.1038/srep35690.


Hyperglycemia Induces Cellular Hypoxia through Production of Mitochondrial ROS Followed by Suppression of Aquaporin-1.

Sada K, Nishikawa T, Kukidome D, Yoshinaga T, Kajihara N, Sonoda K, Senokuchi T, Motoshima H, Matsumura T, Araki E.

PLoS One. 2016 Jul 6;11(7):e0158619. doi: 10.1371/journal.pone.0158619. eCollection 2016.


A 1-year, prospective, observational study of Japanese outpatients with type 1 and type 2 diabetes switching from insulin glargine or detemir to insulin degludec in basal-bolus insulin therapy (Kumamoto Insulin Degludec Observational study).

Shimoda S, Sato M, Sekigami T, Motoshima H, Yoshimura R, Fukuda K, Matsuo Y, Noda H, Okubo M, Ichimori S, Fujisawa K, Fukunaga M, Araki E; Kumamoto Insulin Degludec Observational (KIDUNA) Study Group.

J Diabetes Investig. 2016 Sep;7(5):703-10. doi: 10.1111/jdi.12496. Epub 2016 Mar 19.


Coexistence of resistance to thyroid hormone and papillary thyroid carcinoma.

Igata M, Tsuruzoe K, Kawashima J, Kukidome D, Kondo T, Motoshima H, Shimoda S, Furukawa N, Nishikawa T, Miyamura N, Araki E.

Endocrinol Diabetes Metab Case Rep. 2016;2016:160003. doi: 10.1530/EDM-16-0003. Epub 2016 Mar 30.


Mild Electrical Stimulation with Heat Shock Reduces Visceral Adiposity and Improves Metabolic Abnormalities in Subjects with Metabolic Syndrome or Type 2 Diabetes: Randomized Crossover Trials.

Kondo T, Ono K, Kitano S, Matsuyama R, Goto R, Suico MA, Kawasaki S, Igata M, Kawashima J, Motoshima H, Matsumura T, Kai H, Araki E.

EBioMedicine. 2014 Nov 11;1(1):80-9. doi: 10.1016/j.ebiom.2014.11.001. eCollection 2014 Nov.


Statins meditate anti-atherosclerotic action in smooth muscle cells by peroxisome proliferator-activated receptor-╬│ activation.

Fukuda K, Matsumura T, Senokuchi T, Ishii N, Kinoshita H, Yamada S, Murakami S, Nakao S, Motoshima H, Kondo T, Kukidome D, Kawasaki S, Kawada T, Nishikawa T, Araki E.

Biochem Biophys Res Commun. 2015 Jan 30;457(1):23-30. doi: 10.1016/j.bbrc.2014.12.063. Epub 2014 Dec 19.


Insulin requirement profiles in Japanese hospitalized subjects with type 2 diabetes treated with basal-bolus insulin therapy.

Shimoda S, Okubo M, Koga K, Sekigami T, Kawashima J, Kukidome D, Igata M, Ishii N, Shimakawa A, Matsumura T, Motoshima H, Furukawa N, Nishida K, Araki E.

Endocr J. 2015;62(2):209-16. doi: 10.1507/endocrj.EJ14-0487. Epub 2014 Nov 11.


The role of heat shock response in insulin resistance and diabetes.

Kondo T, Motoshima H, Igata M, Kawashima J, Matsumura T, Kai H, Araki E.

Diabetes Metab J. 2014 Apr;38(2):100-6. doi: 10.4093/dmj.2014.38.2.100. Review.


Comparison of the efficacy of sitagliptin and glimepiride dose-up in Japanese patients with type 2 diabetes poorly controlled by sitagliptin and glimepiride in combination.

Shimoda S, Iwashita S, Sekigami T, Furukawa N, Matsuo Y, Ichimori S, Goto R, Maeda T, Watanabe E, Kondo T, Matsumura T, Motoshima H, Nishida K, Araki E.

J Diabetes Investig. 2014 May 4;5(3):320-6. doi: 10.1111/jdi.12151. Epub 2013 Oct 22.


Cold adaptation: structural and functional characterizations of psychrophilic and mesophilic acetate kinase.

Tang MA, Motoshima H, Watanabe K.

Protein J. 2014 Aug;33(4):313-22. doi: 10.1007/s10930-014-9562-1.


Expression, purification, and characterization of cold-adapted inorganic pyrophosphatase from psychrophilic Shewanella sp. AS-11.

Ginting EL, Iwasaki S, Maeganeku C, Motoshima H, Watanabe K.

Prep Biochem Biotechnol. 2014;44(5):480-92. doi: 10.1080/10826068.2013.833114.


Association between circulating leukocyte subtype counts and carotid intima-media thickness in Japanese subjects with type 2 diabetes.

Matsumura T, Taketa K, Motoshima H, Senokuchi T, Ishii N, Kinoshita H, Fukuda K, Yamada S, Kukidome D, Kondo T, Hisada A, Katoh T, Shimoda S, Nishikawa T, Araki E.

Cardiovasc Diabetol. 2013 Dec 27;12:177. doi: 10.1186/1475-2840-12-177.

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