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Disruption of Dhcr7 and Insig1/2 in cholesterol metabolism causes defects in bone formation and homeostasis through primary cilium formation.

Suzuki A, Ogata K, Yoshioka H, Shim J, Wassif CA, Porter FD, Iwata J.

Bone Res. 2020 Jan 2;8:1. doi: 10.1038/s41413-019-0078-3. eCollection 2020.


Differences in patient-reported outcomes between medial opening-wedge high tibial osteotomy and total knee arthroplasty.

Matsumoto K, Ogawa H, Yoshioka H, Akiyama H.

J Orthop Surg (Hong Kong). 2020 Jan-Apr;28(1):2309499019895636. doi: 10.1177/2309499019895636.


Chronotoxicity of Streptomycin-Induced Renal Injury in Mice.

Yoshioka H, Tominaga S, Shinohara Y, Hwang GW, Maeda T, Miura N.

Biol Pharm Bull. 2020;43(1):53-58. doi: 10.1248/bpb.b19-00539.


Distal tibial tubercle osteotomy is superior to the proximal one for progression of patellofemoral osteoarthritis in medial opening wedge high tibial osteotomy.

Ogawa H, Matsumoto K, Yoshioka H, Sengoku M, Akiyama H.

Knee Surg Sports Traumatol Arthrosc. 2019 Dec 24. doi: 10.1007/s00167-019-05836-1. [Epub ahead of print]


Arthroscopic repair of horizontal cleavage meniscus tears provides good clinical outcomes in spite of poor meniscus healing.

Ogawa H, Matsumoto K, Sengoku M, Yoshioka H, Akiyama H.

Knee Surg Sports Traumatol Arthrosc. 2019 Nov 20. doi: 10.1007/s00167-019-05782-y. [Epub ahead of print]


MicroRNA-124-3p suppresses mouse lip mesenchymal cell proliferation through the regulation of genes associated with cleft lip in the mouse.

Suzuki A, Yoshioka H, Summakia D, Desai NG, Jun G, Jia P, Loose DS, Ogata K, Gajera MV, Zhao Z, Iwata J.

BMC Genomics. 2019 Nov 14;20(1):852. doi: 10.1186/s12864-019-6238-4.


Indirubin 3'-Oxime Inhibits Migration, Invasion, and Metastasis InVivo in Mice Bearing Spontaneously Occurring Pancreatic Cancer via Blocking the RAF/ERK, AKT, and SAPK/JNK Pathways.

Ichimaru Y, Sano M, Kajiwara I, Tobe T, Yoshioka H, Hayashi K, Ijichi H, Miyairi S.

Transl Oncol. 2019 Dec;12(12):1574-1582. doi: 10.1016/j.tranon.2019.08.010. Epub 2019 Oct 28.


Improved Characterisation of Vegetation and Land Surface Seasonal Dynamics in Central Japan with Himawari-8 Hypertemporal Data.

Miura T, Nagai S, Takeuchi M, Ichii K, Yoshioka H.

Sci Rep. 2019 Oct 30;9(1):15692. doi: 10.1038/s41598-019-52076-x.


Biphasic adverse effect of titanium nanoparticles on testicular function in mice.

Miura N, Ohtani K, Hasegawa T, Yoshioka H, Hwang GW.

Sci Rep. 2019 Oct 7;9(1):14373. doi: 10.1038/s41598-019-50741-9.


Critical microRNAs and regulatory motifs in cleft palate identified by a conserved miRNA-TF-gene network approach in humans and mice.

Li A, Jia P, Mallik S, Fei R, Yoshioka H, Suzuki A, Iwata J, Zhao Z.

Brief Bioinform. 2019 Oct 7. pii: bbz082. doi: 10.1093/bib/bbz082. [Epub ahead of print]


Cholesterol metabolism plays a crucial role in the regulation of autophagy for cell differentiation of granular convoluted tubules in male mouse submandibular glands.

Suzuki A, Shim J, Ogata K, Yoshioka H, Iwata J.

Development. 2019 Oct 17;146(20). pii: dev178335. doi: 10.1242/dev.178335.


Diurnal Variation of Sitagliptin-Induced Pharmacological Effects in C57BL/6J Mice.

Yoshioka H, Hirose Y, Ohishi R, Tominaga S, Torii-Goto A, Park SJ, Miura N, Yoshikawa M.

Biol Pharm Bull. 2019;42(9):1562-1568. doi: 10.1248/bpb.b19-00367.


Chronopharmacology of dapagliflozin-induced antihyperglycemic effects in C57BL/6J mice.

Yoshioka H, Ohishi R, Hirose Y, Torii-Goto A, Park SJ, Miura N, Yoshikawa M.

Obes Res Clin Pract. 2019 Sep - Oct;13(5):505-510. doi: 10.1016/j.orcp.2019.08.001. Epub 2019 Aug 26.


Development of a lipoplex-type mRNA carrier composed of an ionizable lipid with a vitamin E scaffold and the KALA peptide for use as an ex vivo dendritic cell-based cancer vaccine.

Tateshita N, Miura N, Tanaka H, Masuda T, Ohtsuki S, Tange K, Nakai Y, Yoshioka H, Akita H.

J Control Release. 2019 Sep 28;310:36-46. doi: 10.1016/j.jconrel.2019.08.002. Epub 2019 Aug 3.


Inhibition of the Inflammatory Pathway Enhances Both the in Vitro and in Vivo Transfection Activity of Exogenous in Vitro-Transcribed mRNAs Delivered by Lipid Nanoparticles.

Ohto T, Konishi M, Tanaka H, Onomoto K, Yoneyama M, Nakai Y, Tange K, Yoshioka H, Akita H.

Biol Pharm Bull. 2019;42(2):299-302. doi: 10.1248/bpb.b18-00783.


The delivery of mRNA to colon inflammatory lesions by lipid-nano-particles containing environmentally-sensitive lipid-like materials with oleic acid scaffolds.

Tanaka H, Watanabe A, Konishi M, Nakai Y, Yoshioka H, Ohkawara T, Takeda H, Harashima H, Akita H.

Heliyon. 2018 Dec 3;4(12):e00959. doi: 10.1016/j.heliyon.2018.e00959. eCollection 2018 Dec.


1O, 20O-diacetyl kamebakaurin protects against acetaminophen-induced hepatotoxicity in mice.

Yoshioka H, Nonogaki T, Ohnishi H, Fukuishi N, Yoshikawa M, Gui MY, Jin YR, Li XW, Adachi Y, Ohno N, Takeya K, Hitotsuyanagi Y, Miura N, Aoyagi Y.

Biomed Res. 2018;39(5):251-260. doi: 10.2220/biomedres.39.251.


Sasa veitchii extract protects against carbon tetrachloride-induced hepatic fibrosis in mice.

Yoshioka H, Nonogaki T, Fukaya S, Ichimaru Y, Nagatsu A, Yoshikawa M, Fujii H, Nakao M.

Environ Health Prev Med. 2018 Oct 15;23(1):49. doi: 10.1186/s12199-018-0739-7.


DNA-loaded nano-adjuvant formed with a vitamin E-scaffold intracellular environmentally-responsive lipid-like material for cancer immunotherapy.

Kawai M, Nakamura T, Miura N, Maeta M, Tanaka H, Ueda K, Higashi K, Moribe K, Tange K, Nakai Y, Yoshioka H, Harashima H, Akita H.

Nanomedicine. 2018 Nov;14(8):2587-2597. doi: 10.1016/j.nano.2018.08.006. Epub 2018 Aug 29.


Development of an Alcohol Dilution-Lyophilization Method for Preparing Lipid Nanoparticles Containing Encapsulated siRNA.

Shirane D, Tanaka H, Nakai Y, Yoshioka H, Akita H.

Biol Pharm Bull. 2018;41(8):1291-1294. doi: 10.1248/bpb.b18-00208.

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