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Items: 19

1.

Gold(III)-Catalyzed Decarboxylative C3-Benzylation of Indole-3-carboxylic Acids with Benzylic Alcohols in Water.

Hikawa H, Kotaki F, Kikkawa S, Azumaya I.

J Org Chem. 2019 Feb 15;84(4):1972-1979. doi: 10.1021/acs.joc.8b02947. Epub 2019 Feb 1.

PMID:
30672696
2.

Cationic palladium(ii)-catalyzed dehydrative nucleophilic substitutions of benzhydryl alcohols with electron-deficient benzenethiols in water.

Hikawa H, Machino Y, Toyomoto M, Kikkawa S, Azumaya I.

Org Biomol Chem. 2016 Aug 7;14(29):7038-45. doi: 10.1039/c6ob01140c. Epub 2016 Jul 1.

PMID:
27363665
3.

A phenotypic drug discovery study on thienodiazepine derivatives as inhibitors of T cell proliferation induced by CD28 co-stimulation leads to the discovery of a first bromodomain inhibitor.

Endo J, Hikawa H, Hamada M, Ishibuchi S, Fujie N, Sugiyama N, Tanaka M, Kobayashi H, Sugahara K, Oshita K, Iwata K, Ooike S, Murata M, Sumichika H, Chiba K, Adachi K.

Bioorg Med Chem Lett. 2016 Mar 1;26(5):1365-70. doi: 10.1016/j.bmcl.2016.01.084. Epub 2016 Feb 2.

PMID:
26869194
4.

Direct substitution of benzylic alcohols with electron-deficient benzenethiols viaπ-benzylpalladium(ii) in water.

Hikawa H, Toyomoto M, Kikkawa S, Azumaya I.

Org Biomol Chem. 2015 Dec 21;13(47):11459-65. doi: 10.1039/c5ob01717c. Epub 2015 Oct 9.

PMID:
26451799
5.

Enantiomeric Separation of Monosubstituted Tryptophan Derivatives and Metabolites by HPLC with a Cinchona Alkaloid-Based Zwitterionic Chiral Stationary Phase and Its Application to the Evaluation of the Optical Purity of Synthesized 6-Chloro-l-Tryptophan.

Fukushima T, Sugiura A, Furuta I, Iwasa S, Iizuka H, Ichiba H, Onozato M, Hikawa H, Yokoyama Y.

Int J Tryptophan Res. 2015 Jan 7;8:1-5. doi: 10.4137/IJTR.S20381. eCollection 2015.

6.

Spectroscopic investigation for the interaction of mycophenolate mofetil with ferrous ions.

Sakai M, Kaneko S, Nakamura M, Murakami Y, Hikawa H, Azumaya I, Nakakoshi M, Yokoyama Y.

Chem Pharm Bull (Tokyo). 2014;62(11):1131-5.

7.

Enantioselective desymmetrization of FTY720.

Hikawa H, Hamada M, Uchida Y, Kikkawa S, Yokoyama Y, Azumaya I.

Chem Pharm Bull (Tokyo). 2014;62(10):1041-4.

8.

[Liposome modified with VIP-lipopeptide as a new drug delivery system].

Masaka T, Li Y, Kawatobi S, Koide Y, Takami A, Yano K, Imai R, Yagi N, Suzuki H, Hikawa H, Tatsuno I, Terada K, Yokoyama Y.

Yakugaku Zasshi. 2014;134(9):987-95. Japanese.

9.
10.

Au(III)/TPPMS-catalyzed benzylation of indoles with benzylic alcohols in water.

Hikawa H, Suzuki H, Azumaya I.

J Org Chem. 2013 Dec 6;78(23):12128-35. doi: 10.1021/jo402151g. Epub 2013 Nov 22.

PMID:
24256426
11.

Synthesis of VIP-lipopeptide using a new linker to modify liposomes: towards the development of a drug delivery system for active targeting.

Masaka T, Matsuda T, Li Y, Koide Y, Takami A, Yano K, Imai R, Ichihara R, Yagi N, Suzuki H, Hikawa H, Terada K, Yokoyama Y.

Chem Pharm Bull (Tokyo). 2013;61(11):1184-7. Epub 2013 Aug 23.

12.

Chemoselective benzylation of unprotected anthranilic acids with benzhydryl alcohols by water-soluble Au(III)/TPPMS in water.

Hikawa H, Suzuki H, Yokoyama Y, Azumaya I.

J Org Chem. 2013 Jul 5;78(13):6714-20. doi: 10.1021/jo401064f. Epub 2013 Jun 18.

PMID:
23745757
13.

Synthesis and biological evaluation of novel tryptoline derivatives as indoleamine 2,3-dioxygenase (IDO) inhibitors.

Tanaka M, Li X, Hikawa H, Suzuki T, Tsutsumi K, Sato M, Takikawa O, Suzuki H, Yokoyama Y.

Bioorg Med Chem. 2013 Mar 1;21(5):1159-65. doi: 10.1016/j.bmc.2012.12.028. Epub 2013 Jan 3.

PMID:
23337802
14.

Synthesis of a key intermediate for the preparation of FTY720 analogs.

Hamada M, Adachi K, Hikawa H, Yokoyama Y.

Chem Pharm Bull (Tokyo). 2012;60(11):1395-8.

15.

Pd-catalyzed benzylic C-H amidation with benzyl alcohols in water: a strategy to construct quinazolinones.

Hikawa H, Ino Y, Suzuki H, Yokoyama Y.

J Org Chem. 2012 Aug 17;77(16):7046-51. doi: 10.1021/jo301282n. Epub 2012 Aug 9.

PMID:
22852777
16.

Palladium-catalyzed S-benzylation of unprotected mercaptobenzoic acid with benzyl alcohols in water.

Hikawa H, Yokoyama Y.

Org Biomol Chem. 2012 Apr 21;10(15):2942-5. doi: 10.1039/c2ob25091h. Epub 2012 Mar 8.

PMID:
22402746
17.

Palladium-catalyzed benzylation of unprotected anthranilic acids with benzyl alcohols in water.

Hikawa H, Yokoyama Y.

Org Lett. 2011 Dec 16;13(24):6512-5. doi: 10.1021/ol2028042. Epub 2011 Nov 16.

PMID:
22087729
18.

Palladium-catalyzed mono-N-allylation of unprotected anthranilic acids with allylic alcohols in aqueous media.

Hikawa H, Yokoyama Y.

J Org Chem. 2011 Oct 21;76(20):8433-9. doi: 10.1021/jo201691e. Epub 2011 Sep 29.

PMID:
21919524
19.

Palladium-catalyzed mono-N-allylation of unprotected amino acids with 1,1-dimethylallyl alcohol in water.

Hikawa H, Yokoyama Y.

Org Biomol Chem. 2011 Jun 7;9(11):4044-50. doi: 10.1039/c1ob05238a. Epub 2011 Apr 19.

PMID:
21505697

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