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Items: 1 to 20 of 157


Copper-Heparin Inhalation Therapy To Repair Emphysema: A Scientific Rationale.

Janssen R, Wouters EF, Janssens W, Daamen WF, Hagedoorn P, de Wit HA, Serré J, Gayan-Ramirez G, Franssen FM, Reynaert NL, von der Thüsen JH, Frijlink HW.

Int J Chron Obstruct Pulmon Dis. 2019 Nov 25;14:2587-2602. doi: 10.2147/COPD.S228411. eCollection 2019.


Eradication of Pseudomonas aeruginosa in cystic fibrosis patients with inhalation of dry powder tobramycin.

Akkerman-Nijland AM, Yousofi M, Rottier BL, Van der Vaart H, Burgerhof JGM, Frijlink HW, Touw DJ, Koppelman GH, Akkerman OW.

Ther Adv Respir Dis. 2020 Jan-Dec;14:1753466620905279. doi: 10.1177/1753466620905279.


Dispersibility and Storage Stability Optimization of High Dose Isoniazid Dry Powder Inhalation Formulations with L-Leucine or Trileucine.

Sibum I, Hagedoorn P, Kluitman MPG, Kloezen M, Frijlink HW, Grasmeijer F.

Pharmaceutics. 2019 Dec 25;12(1). pii: E24. doi: 10.3390/pharmaceutics12010024.


Pulmonary immunization: deposition site is of minor relevance for influenza vaccination but deep lung deposition is crucial for hepatitis B vaccination.

Tomar J, Tonnis WF, Patil HP, de Boer AH, Hagedoorn P, Vanbever R, Frijlink HW, Hinrichs WLJ.

Acta Pharm Sin B. 2019 Nov;9(6):1231-1240. doi: 10.1016/j.apsb.2019.05.003. Epub 2019 May 28.


The effects of oxygen concentration on cell death, anti-oxidant transcription, acute inflammation, and cell proliferation in precision-cut lung slices.

Ruigrok MJR, Tomar J, Frijlink HW, Melgert BN, Hinrichs WLJ, Olinga P.

Sci Rep. 2019 Nov 7;9(1):16239. doi: 10.1038/s41598-019-52813-2.


Development of a Stable Respiratory Syncytial Virus Pre-Fusion Protein Powder Suitable for a Core-Shell Implant with a Delayed Release in Mice: A Proof of Concept Study.

Beugeling M, Amssoms K, Cox F, De Clerck B, Van Gulck E, Verwoerd JA, Kraus G, Roymans D, Baert L, Frijlink HW, Hinrichs WLJ.

Pharmaceutics. 2019 Oct 3;11(10). pii: E510. doi: 10.3390/pharmaceutics11100510.


Inhomogeneous Distribution of Components in Solid Protein Pharmaceuticals: Origins, Consequences, Analysis, and Resolutions.

Nguyen KTT, Frijlink HW, Hinrichs WLJ.

J Pharm Sci. 2020 Jan;109(1):134-153. doi: 10.1016/j.xphs.2019.10.010. Epub 2019 Oct 10. Review.


The Effect of Food on the Pharmacokinetics of Sildenafil after Single Administration of a Sublingual Testosterone and Oral Sildenafil Combination Tablet in Healthy Female Subjects.

Bloemers J, Gerritsen J, van Rooij K, de Leede L, van der Geest R, Frijlink HW, Koppeschaar HPF, Olivier B, Tuiten A.

J Sex Med. 2019 Sep;16(9):1433-1443. doi: 10.1016/j.jsxm.2019.06.015.


Efficacy and Safety of Peppermint Oil in a Randomized, Double-Blind Trial of Patients With Irritable Bowel Syndrome.

Weerts ZZRM, Masclee AAM, Witteman BJM, Clemens CHM, Winkens B, Brouwers JRBJ, Frijlink HW, Muris JWM, De Wit NJ, Essers BAB, Tack J, Snijkers JTW, Bours AMH, de Ruiter-van der Ploeg AS, Jonkers DMAE, Keszthelyi D.

Gastroenterology. 2020 Jan;158(1):123-136. doi: 10.1053/j.gastro.2019.08.026. Epub 2019 Aug 27.


Towards the Oral Treatment of Ileo-Colonic Inflammatory Bowel Disease with Infliximab Tablets: Development and Validation of the Production Process.

Gareb B, Posthumus S, Beugeling M, Koopmans P, Touw DJ, Dijkstra G, Kosterink JGW, Frijlink HW.

Pharmaceutics. 2019 Aug 23;11(9). pii: E428. doi: 10.3390/pharmaceutics11090428.


Respiratory syncytial virus subunit vaccines based on the viral envelope glycoproteins intended for pregnant women and the elderly.

Beugeling M, De Zee J, Woerdenbag HJ, Frijlink HW, Wilschut JC, Hinrichs WLJ.

Expert Rev Vaccines. 2019 Sep;18(9):935-950. doi: 10.1080/14760584.2019.1657013. Epub 2019 Aug 25.


A gastrointestinal simulation system for dissolution of oral solid dosage forms before and after Roux-en-Y gastric bypass.

Yska JP, Punter RJ, Woerdenbag HJ, Emous M, Frijlink HW, Wilffert B, van Roon EN.

Eur J Hosp Pharm. 2019 May;26(3):152-156. doi: 10.1136/ejhpharm-2017-001360. Epub 2018 Feb 8.


Oromucosal films: from patient centricity to production by printing techniques.

Tian Y, Orlu M, Woerdenbag HJ, Scarpa M, Kiefer O, Kottke D, Sjöholm E, Öblom H, Sandler N, Hinrichs WLJ, Frijlink HW, Breitkreutz J, Visser JC.

Expert Opin Drug Deliv. 2019 Sep;16(9):981-993. doi: 10.1080/17425247.2019.1652595. Epub 2019 Aug 8.


Pharmacokinetics and tolerability of inhaled levodopa from a new dry-powder inhaler in patients with Parkinson's disease.

Luinstra M, Rutgers W, van Laar T, Grasmeijer F, Begeman A, Isufi V, Steenhuis L, Hagedoorn P, de Boer A, Frijlink HW.

Ther Adv Chronic Dis. 2019 Jun 21;10:2040622319857617. doi: 10.1177/2040622319857617. eCollection 2019.


Nasal gene expression changes with inhaled corticosteroid treatment in asthma.

Boudewijn IM, Lan A, Faiz A, Cox CA, Brouwer S, Schokker S, Vroegop SJ, Nawijn MC, Woodruff PG, Christenson SA, Hagedoorn P, Frijlink HW, Choy DF, Brouwer U, Wisman M, Postma DS, Fingleton J, Beasley R, van den Berge M, Guryev V.

Allergy. 2020 Jan;75(1):191-194. doi: 10.1111/all.13952. Epub 2019 Jul 15. No abstract available.


Characterization and Formulation of Isoniazid for High-Dose Dry Powder Inhalation.

Sibum I, Hagedoorn P, Frijlink HW, Grasmeijer F.

Pharmaceutics. 2019 May 13;11(5). pii: E233. doi: 10.3390/pharmaceutics11050233.


Associations of AMP and adenosine induced dyspnea sensation to large and small airways dysfunction in asthma.

Cox CA, Boudewijn IM, Vroegop SJ, Schokker S, Lexmond AJ, Frijlink HW, Hagedoorn P, Vonk JM, Farenhorst MP, Ten Hacken NHT, Kerstjens HAM, van den Berge M.

BMC Pulm Med. 2019 Jan 28;19(1):23. doi: 10.1186/s12890-019-0783-0.


A systematic review and meta-analysis of microbial contamination of parenteral medication prepared in a clinical versus pharmacy environment.

Larmené-Beld KHM, Frijlink HW, Taxis K.

Eur J Clin Pharmacol. 2019 May;75(5):609-617. doi: 10.1007/s00228-019-02631-2. Epub 2019 Jan 25. Review.


Predictors of clinical response to extrafine and non-extrafine particle inhaled corticosteroids in smokers and ex-smokers with asthma.

Gafar F, Boudewijn IM, Cox CA, Vonk JM, Schokker S, Lexmond AJ, Frijlink HW, Hagedoorn P, Postma DS, van den Berge M.

Respir Res. 2018 Dec 18;19(1):256. doi: 10.1186/s12931-018-0961-2.


Identifying critical process steps to protein stability during spray drying using a vibrating mesh or a two-fluid nozzle.

Grasmeijer N, Tiraboschi V, Woerdenbag HJ, Frijlink HW, Hinrichs WLJ.

Eur J Pharm Sci. 2019 Feb 1;128:152-157. doi: 10.1016/j.ejps.2018.11.027. Epub 2018 Dec 3.

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