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Items: 1 to 20 of 122

1.

DNA damage in human whole blood caused by radiopharmaceuticals evaluated by the comet assay.

Schmeiser HH, Muehlbauer KR, Mier W, Baranski AC, Neels O, Dimitrakopoulou-Strauss A, Schmezer P, Kratochwil C, Bruchertseifer F, Morgenstern A, Kopka K.

Mutagenesis. 2019 May 20. pii: gez007. doi: 10.1093/mutage/gez007. [Epub ahead of print]

PMID:
31107537
2.

Ellipticine-loaded apoferritin nanocarrier retains DNA adduct-based cytochrome P450-facilitated toxicity in neuroblastoma cells.

Indra R, Černá T, Heger Z, Hraběta J, Wilhelm M, Dostálová S, Lengálová A, Martínková M, Adam V, Eckschlager T, Schmeiser HH, Arlt VM, Stiborová M.

Toxicology. 2019 May 1;419:40-54. doi: 10.1016/j.tox.2019.03.009. Epub 2019 Mar 23.

PMID:
30914192
3.

Determination of genomic N3-methylthymidine in human cancer cells treated with nitrosamines using capillary electrophoresis with laser-induced fluorescence.

Krais AM, Kliem C, Arlt VM, Schmeiser HH.

Electrophoresis. 2019 Jun;40(11):1535-1539. doi: 10.1002/elps.201800495. Epub 2019 Feb 27.

PMID:
30767246
4.

Sensitive detection of hydroxymethylcytosine levels in normal and neoplastic cells and tissues.

Krais AM, Park YJ, Reifenberger G, Meister M, Plass C, Schmeiser HH.

Electrophoresis. 2019 May;40(9):1293-1297. doi: 10.1002/elps.201800523. Epub 2019 Feb 14.

PMID:
30724377
5.

Application of hepatic cytochrome b5/P450 reductase null (HBRN) mice to study the role of cytochrome b5 in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticine.

Reed L, Indra R, Mrizova I, Moserova M, Schmeiser HH, Wolf CR, Henderson CJ, Stiborova M, Phillips DH, Arlt VM.

Toxicol Appl Pharmacol. 2019 Mar 1;366:64-74. doi: 10.1016/j.taap.2019.01.020. Epub 2019 Jan 25.

6.
7.

Exposure to endocrine disruptors 17alpha-ethinylestradiol and estradiol influences cytochrome P450 1A1-mediated genotoxicity of benzo[a]pyrene and expression of this enzyme in rats.

Stiborová M, Dračínská H, Bořek-Dohalská L, Klusoňová Z, Holecová J, Martínková M, Schmeiser HH, Arlt VM.

Toxicology. 2018 May 1;400-401:48-56. doi: 10.1016/j.tox.2018.04.001. Epub 2018 Apr 9.

8.

Erratum to "Gene expression profiles modulated by the human carcinogen aristolochic acid I in human cancer cells and their dependence on TP53" [Toxicol. Appl. Pharmacol. 232(1) (2008) 86-98].

Simões ML, Hockley SL, Schwerdtle T, da Costa GG, Schmeiser HH, Phillips DH, Arlt VM.

Toxicol Appl Pharmacol. 2018 Apr 1;344:75. doi: 10.1016/j.taap.2018.02.010. Epub 2018 Feb 20. No abstract available.

PMID:
29471084
9.

Cytochrome b 5 impacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation: studies in hepatic cytochrome b 5 /P450 reductase null (HBRN) mice.

Reed L, Mrizova I, Barta F, Indra R, Moserova M, Kopka K, Schmeiser HH, Wolf CR, Henderson CJ, Stiborova M, Phillips DH, Arlt VM.

Arch Toxicol. 2018 Apr;92(4):1625-1638. doi: 10.1007/s00204-018-2162-7. Epub 2018 Jan 24.

10.

The Histone Deacetylase Inhibitor Valproic Acid Exerts a Synergistic Cytotoxicity with the DNA-Damaging Drug Ellipticine in Neuroblastoma Cells.

Cerna T, Hrabeta J, Eckschlager T, Frei E, Schmeiser HH, Arlt VM, Stiborová M.

Int J Mol Sci. 2018 Jan 5;19(1). pii: E164. doi: 10.3390/ijms19010164.

11.

Cytochrome b5 plays a dual role in the reaction cycle of cytochrome P450 3A4 during oxidation of the anticancer drug ellipticine.

Stiborová M, Indra R, Frei E, Kopečková K, Schmeiser HH, Eckschlager T, Adam V, Heger Z, Arlt VM, Martínek V.

Monatsh Chem. 2017;148(11):1983-1991. doi: 10.1007/s00706-017-1986-9. Epub 2017 Jul 4.

12.

Comparison of the oxidation of carcinogenic aristolochic acid I and II by microsomal cytochromes P450 in vitro: experimental and theoretical approaches.

Martínek V, Bárta F, Hodek P, Frei E, Schmeiser HH, Arlt VM, Stiborová M.

Monatsh Chem. 2017;148(11):1971-1981. doi: 10.1007/s00706-017-2014-9. Epub 2017 Jul 26.

13.

Comparison of human cytochrome P450 1A1-catalysed oxidation of benzo[a]pyrene in prokaryotic and eukaryotic expression systems.

Stiborová M, Indra R, Moserová M, Bořek-Dohalská L, Hodek P, Frei E, Kopka K, Schmeiser HH, Arlt VM.

Monatsh Chem. 2017;148(11):1959-1969. doi: 10.1007/s00706-017-2002-0. Epub 2017 Jul 10.

14.

DNA Adducts Formed by Aristolochic Acid Are Unique Biomarkers of Exposure and Explain the Initiation Phase of Upper Urothelial Cancer.

Stiborová M, Arlt VM, Schmeiser HH.

Int J Mol Sci. 2017 Oct 14;18(10). pii: E2144. doi: 10.3390/ijms18102144. Review.

15.

Correction to NADH:Cytochrome b5 Reductase and Cytochrome b5 Can Act as Sole Electron Donors to Human Cytochrome P450 1A1-Mediated Oxidation and DNA Adduct Formation by Benzo[a]pyrene.

Stiborová M, Indra R, Moserová M, Frei E, Schmeiser HH, Kopka K, Phillips DH, Arlt VM.

Chem Res Toxicol. 2016 Sep 19;29(9):1571. doi: 10.1021/acs.chemrestox.6b00283. Epub 2016 Aug 30. No abstract available.

16.

Impact of genetic modulation of SULT1A enzymes on DNA adduct formation by aristolochic acids and 3-nitrobenzanthrone.

Arlt VM, Meinl W, Florian S, Nagy E, Barta F, Thomann M, Mrizova I, Krais AM, Liu M, Richards M, Mirza A, Kopka K, Phillips DH, Glatt H, Stiborova M, Schmeiser HH.

Arch Toxicol. 2017 Apr;91(4):1957-1975. doi: 10.1007/s00204-016-1808-6. Epub 2016 Aug 24.

17.

Balkan endemic nephropathy: an update on its aetiology.

Stiborová M, Arlt VM, Schmeiser HH.

Arch Toxicol. 2016 Nov;90(11):2595-2615. Epub 2016 Aug 19. Review.

18.

NADH:Cytochrome b5 Reductase and Cytochrome b5 Can Act as Sole Electron Donors to Human Cytochrome P450 1A1-Mediated Oxidation and DNA Adduct Formation by Benzo[a]pyrene.

Stiborová M, Indra R, Moserová M, Frei E, Schmeiser HH, Kopka K, Phillips DH, Arlt VM.

Chem Res Toxicol. 2016 Aug 15;29(8):1325-34. doi: 10.1021/acs.chemrestox.6b00143. Epub 2016 Jul 20. Erratum in: Chem Res Toxicol. 2016 Sep 19;29(9):1571.

19.

Epoxyeicosatrienoic acids (EETs) form adducts with DNA in vitro.

Funk DJ, Sorg BL, Kopka K, Schmeiser HH.

Prostaglandins Other Lipid Mediat. 2016 Mar;123:63-7. doi: 10.1016/j.prostaglandins.2016.04.006. Epub 2016 May 7.

PMID:
27166927
20.

Induced expression of microsomal cytochrome b5 determined at mRNA and protein levels in rats exposed to ellipticine, benzo[a]pyrene, and 1-phenylazo-2-naphthol (Sudan I).

Stiborová M, Moserová M, Mrízová I, Dračínská H, Martínek V, Indra R, Frei E, Adam V, Kizek R, Schmeiser HH, Kubáčková K, Arlt VM.

Monatsh Chem. 2016;147:897-904. Epub 2016 Jan 12.

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